Eicosanoid synthesis (Pan troglodytes)

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12-Hydroperoxy Eicosatetraenoic Acid6-Keto-Prostaglandin F2-alphaProstaglandin E2Thromboxane A3Cell Membrane15-Hydroperoxy Eicosatetraenoic AcidLTC4SPTGS25-HETEProstaglandin I2Peroxidase?5-HPETE12-HETELeukotriene C4ALOX5ALOX15Arachidonic acidPLA2G2AProstaglandin D2PTGISGGT1Peroxidase?DPEP1Peroxidase?PTGDSALOX1515-HETELeukotriene D4PTGESPTGS1Thromboxane A2ALOX12PNPLA8PLA2G6PLA2G6Prostaglandin F2aLeukotriene E4Leukotriene B4ALOX15BPTGES2ALOX5APALOX5APThromboxane B2Prostaglandin H2PGE2 9-ketoreducLTA4HTBXAS1Leukotriene A4ALOX5PGD2 11-ketoreduc


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 64% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117389view10:32, 21 May 2021EweitzModified title
106916view13:38, 17 September 2019MaintBotHMDB identifier normalization
89538view11:07, 16 September 2016Mkutmonontology tag fix
89480view13:39, 15 September 2016Mkutmonremove space from ontology term id
78368view10:19, 7 January 2015MaintBotadded missing graphIds
71678view19:41, 17 October 2013MaintBotAutomated update of data sources
69276view18:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67187view10:18, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62743view03:35, 2 May 2013MaintBotUpdated UniProt data source
41585view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35482view12:16, 12 February 2010Thomasadded literature
35478view12:14, 12 February 2010ThomasModified description
34314view22:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33524view09:32, 1 December 2009MaintBotRemoved group label
30423view21:16, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB01193 (HMDB)
ALOX12GeneProduct455242 (Entrez Gene)
ALOX15GeneProduct748294 (Entrez Gene)
ALOX15BGeneProduct455104 (Entrez Gene)
ALOX5GeneProduct450428 (Entrez Gene)
ALOX5APGeneProduct452520 (Entrez Gene)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
DPEP1GeneProduct
GGT1GeneProduct470168 (Entrez Gene)
LTA4HGeneProduct452145 (Entrez Gene)
LTC4SGeneProduct739986 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct456587 (Entrez Gene)
PLA2G6GeneProduct
PNPLA8GeneProduct472484 (Entrez Gene)
PTGDSGeneProduct749402 (Entrez Gene)
PTGES2GeneProduct464763 (Entrez Gene)
PTGESGeneProduct473071 (Entrez Gene)
PTGISGeneProduct458323 (Entrez Gene)
PTGS1GeneProduct464713 (Entrez Gene)
PTGS2GeneProduct469616 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
TBXAS1GeneProduct463774 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)

Annotated Interactions

No annotated interactions
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