Eukaryotic transcription initiation (Canis familiaris)

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(small stable RNAs)Steps 2) Association of TIFs and RNA polymerase5TFIIHSteps 5) RNA elongation with CDT phosphorylationRNA polymerase IITFIIBTFIIESteps 3) DNA melting by association with TFIIHTranscription Initiation Factors (TIFs)TFIIF(recognize surface DNA geometry)TFIIHGene Regulatory ProteinsRNA pol II35TATA Box bindingproteinSteps 4) Transcription elongation by NTPs(large ribosomal RNAs)RNA polymerase ISteps 1) TBP binds TATA boxTATA3dsDNATFIIETFIID5TFIIDTFIIARNA polymerase IIITFIIA33TATATFIIB53TATA555533cell growthPrimary RNA transcript553(mRNA, snRNPs)TFIIFTFIIF3POLR2KRHOXF2POLR2JGTF2H3TAF7GTF2E1ILKTAF6CCNHPOLR1DGTF2F2POLR1BPOLR3EGTF2H1GTF2E2GTF2BERCC3POLR3BTAF9MNAT1POLR3DTAF5TAF12POLR2CPOLR2ICDK7POLR3KGTF2H2TBPPOLR2EPOLR2APOLR1APOLR2GPOLR2FPOLR2BGTF2A2POLR2HERCC2POLR3HTAF13GTF2H4


Description

No description

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
GenMAPP remarks 
right click for notes & references
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP405(r29565) with a 85% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117449view10:52, 21 May 2021EweitzModified title
68516view21:59, 5 July 2013MaintBotUpdated to 2013 gpml schema
67209view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
48167view20:27, 9 May 2012MaintBotUpdating from human to fix xrefs
40669view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
35524view13:55, 12 February 2010Thomasadded literature
35513view13:49, 12 February 2010ThomasModified description
35511view13:48, 12 February 2010ThomasModified description
32265view13:02, 15 August 2009MaintBotFixed text labels
31792view12:15, 14 August 2009MaintBotFixed group labels
31293view20:08, 13 August 2009MaintBotFixed text labels
30751view23:07, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCNHGeneProduct479156 (Entrez Gene)
CDK7GeneProduct608441 (Entrez Gene)
ERCC2GeneProduct493995 (Entrez Gene)
ERCC3GeneProduct476105 (Entrez Gene)
GTF2A2GeneProduct478327 (Entrez Gene)
GTF2BGeneProduct479960 (Entrez Gene)
GTF2E1GeneProduct488002 (Entrez Gene)
GTF2E2GeneProduct475597 (Entrez Gene)
GTF2F2GeneProduct609164 (Entrez Gene)
GTF2H1GeneProduct476881 (Entrez Gene)
GTF2H2GeneProduct478089 (Entrez Gene)
GTF2H3GeneProduct477446 (Entrez Gene)
GTF2H4GeneProduct606988 (Entrez Gene)
ILKGeneProduct476836 (Entrez Gene)
MNAT1GeneProduct480346 (Entrez Gene)
POLR1AGeneProduct475766 (Entrez Gene)
POLR1BGeneProduct
POLR1DGeneProduct
POLR2AGeneProduct479483 (Entrez Gene)
POLR2BGeneProduct475152 (Entrez Gene)
POLR2CGeneProduct478109 (Entrez Gene)
POLR2EGeneProduct611859 (Entrez Gene)
POLR2FGeneProduct474512 (Entrez Gene)
POLR2GGeneProduct476052 (Entrez Gene)
POLR2HGeneProduct478656 (Entrez Gene)
POLR2IGeneProduct476476 (Entrez Gene)
POLR2JGeneProduct
POLR2KGeneProduct
POLR3BGeneProduct474531 (Entrez Gene)
POLR3DGeneProduct609056 (Entrez Gene)
POLR3EGeneProduct608689 (Entrez Gene)
POLR3HGeneProduct607850 (Entrez Gene)
POLR3KGeneProduct611625 (Entrez Gene)
RHOXF2GeneProduct611154 (Entrez Gene)
TAF12GeneProduct
TAF13GeneProduct476973 (Entrez Gene)
TAF5GeneProduct
TAF6GeneProduct489846 (Entrez Gene)
TAF7GeneProduct487180 (Entrez Gene)
TAF9GeneProduct480815 (Entrez Gene)
TBPGeneProduct611193 (Entrez Gene)

Annotated Interactions

No annotated interactions
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