EGF/EGFR signaling (Homo sapiens)

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1CYAutodephosphorylationNUCYCYMAPlasma membraneMANUNUPMCY(Protein-protein interaction)NUCYPMMACYEnzyme complexPMAccession Number : NetPath 4; cellmap:4CYCYPMPMGlycosylationMolecule in the pathwayMTENCYPMPMMAMolecular associationPMPMMACYPhosphorylationDemethylationPMPMCYNUCYCYCYDeubiquitinationMAControlPMProteins in a complex interactionNUCYPMMAPMDAcetylationPMActivationECNUNUMANUMAMethylationPMCYTranslocationCYRecruitmentNUMAMAEndosomeLigandProteolytic cleavageCYDeacetylationMANUCYMANucleusDesumoylationCYCYCYENMADNUMAReceptorNUReaction through unknown mechanisms/moleculesCYGolgi apparatusGOMitochondrionSumoylationCYNUDephosphorylationMANUPalmitoylationPMENPMMANUCytoplasmPMUbiquitinationEndoplasmic reticulumCYGene SymbolMAPMCYNUMAPMMAInhibitionCYMACYCYCYCYNUCYAutophosphorylationCYCYNUExtracellularDPMNUERCYKLF11ELK1EGFRPRKAR1AEPPK1PIK3CBKRT8CRKLATF1CEBPBELF3PIK3CGRPS6KA2SNRPD2STAT2PLCG2PIK3R2GAB2PRKCZHAT1TNIP1SH3GL3JAK1RIPK1WASLSH3GL2CREB1CBLBMAP2K1ARF4PLCG1PAK1DUSP1STXBP1APPLSTAT5AEGFMAPK1SPRY2ZNF259SH3BGRLEGFRRBBP7SOS1KRT18RPS6KA3STAT2PIK3CAPTPN11EGFSTAT1PLCG1PIK3R3HIP1PLEC1TNK2RPS6KA3ABI1PRKCIGAB1KRAS2EPS15AP2A1RGS16SMAD2PLSCR1VAV3BCAR1DIP13BSPRY2RPS6KA5HRASMAP2K7RASA1CSKBCAR1MAP2K2PKN2PRKCB1EGFRPIK3R1JAK2RALGDSPLCG2PRKCASIN3AMAP3K4GAB1SHC1PXNVAV2TGIFSTAT5BCDC42HIST3H3PTPN5NRASMAPK8STAT3ITCHSOCS1AKT1GIT1DNM1STAT3PRKCAMAPK3RPS6KA1RFXANKWNK1JUNSHOC2DOK2MYCSTAT5AEGFEEF1A1PRKCGRAC1SMAD3FOSMAP2K1HDAC1EEF1A1PTPN6GJA1SMAD3RAF1PTK6RAF1ARF4PTPN12MAP3K3CBLMAP2K3RALBPLD2RALBP1SMAD2CASP9USP6NLMTA2GRB2CAMK2ASTAT1GRB10CAV1ELK4DUSP1NCK2MAPK7YWHABNDUFA13ELF3EGFRMAPK14MAPK1DIP13BARAFKRT17EPN1PRKCMFOXO1ACRKCAV2GRB14REPS2CEBPAKRT7VAV1ARF4ERRFI1RAB5APLD1PTK2BSTAT3DDEF1INPPL1STXBP1PTPN6SP1MAP3K2MCF2ZNF259GRB7PIK3C2BFOXO1ASH2D3CSOCS3CTNND1STAT1SRCJUNDREPS1MAP3K14CEACAM1EPS15APPLSH3GL2PTPRRSH3KBP1PIK3CDMAP3K1PEBP1PLD1EPS8EPS15L1MAP3K2CBLCSOS2SH2D3CMAP2K5SNCASHC1HDAPPLNCK1PITPNA


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

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Bibliography

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History

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CompareRevisionActionTimeUserComment
129679view00:46, 22 May 2024EweitzModified title
126309view17:28, 20 April 2023EgonwLicense is CCZero
120689view12:47, 23 December 2021EweitzStandardize font, weight, case
118995view09:26, 8 June 2021FinterlyRemoved empty Comment
116546view12:14, 7 May 2021EweitzModified title
115923view20:35, 20 March 2021EgonwModified description
111019view14:22, 30 June 2020L DupuisConverted interaction lines in legend to graphical lines
106392view21:27, 28 August 2019KhanspersModified description
105574view06:29, 9 August 2019KhanspersModified description
79266view20:32, 19 March 2015ZariChenged Identifier for PXN
78502view10:29, 7 January 2015MaintBotadded missing graphIds
72106view22:03, 24 October 2013AlexanderPicoadded xrefs
71357view18:35, 17 October 2013MaintBotAutomated update of data sources
70625view21:22, 16 August 2013MaintBotUpdated xrefs from Anatoly Urisman
67174view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
63177view20:30, 8 May 2013MaintBotUpdating gpml version
47973view14:23, 23 April 2012NetPathModified description
44600view21:09, 21 September 2011KhanspersUpdating content to NetSlim
44120view20:50, 24 August 2011KhanspersReverted to version '23:15, 1 March 2011' by Khanspers
44017view22:41, 22 August 2011Khanspers
44009view22:10, 22 August 2011KhanspersModified description
44008view22:05, 22 August 2011KhanspersModified description
44007view22:03, 22 August 2011KhanspersModified description
44006view22:00, 22 August 2011KhanspersUpdating pathway from NetSlim
41034view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35716view23:27, 12 February 2010AlexanderPico
35432view11:23, 12 February 2010MichielChanged literature reference
35428view11:06, 12 February 2010MichielAdded literature reference
35300view23:23, 11 February 2010NsalomonisModified description
21600view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:EGFR1 NetPath 4]] moved to [[Pathway:WP437]]: Moved to stable identifier
7996view13:46, 7 January 2008MaintBot[[Pathway:Human:EGFR1 NetPath 4]] moved to [[Pathway:Homo sapiens:EGFR1 NetPath 4]]: Renaming species
7621view16:05, 18 December 2007MaintBotfixed category names
7215view12:33, 4 November 2007MaintBotAdded categories to GPML
6309view22:17, 22 May 2007A.Pandeygpml file for [[Human:EGFR1_NetPath_4]]

External references

DataNodes

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NameTypeDatabase referenceComment
ABI1GeneProduct10006 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
AP2A1GeneProduct160 (Entrez Gene)
APPLGeneProduct26060 (Entrez Gene)
ARAFGeneProduct369 (Entrez Gene)
ARF4GeneProduct378 (Entrez Gene)
ATF1GeneProduct466 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene)
CAV2GeneProduct858 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
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CDC42GeneProduct998 (Entrez Gene)
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CREB1GeneProduct1385 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
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DDEF1GeneProduct50807 (Entrez Gene)
DIP13BGeneProduct55198 (Entrez Gene)
DNM1GeneProduct1759 (Entrez Gene)
DOK2GeneProduct9046 (Entrez Gene)
DUSP1GeneProduct1843 (Entrez Gene)
EEF1A1GeneProduct1915 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ELF3GeneProduct1999 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
ELK4GeneProduct2005 (Entrez Gene)
EPN1GeneProduct29924 (Entrez Gene)
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EPS15GeneProduct2060 (Entrez Gene)
EPS15L1GeneProduct58513 (Entrez Gene)
EPS8GeneProduct2059 (Entrez Gene)
ERRFI1GeneProduct54206 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
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HIP1GeneProduct3092 (Entrez Gene)
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HRASGeneProduct3265 (Entrez Gene)
INPPL1GeneProduct3636 (Entrez Gene)
ITCHGeneProduct83737 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
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JUNGeneProduct3725 (Entrez Gene)
JUNDGeneProduct3727 (Entrez Gene)
KLF11GeneProduct8462 (Entrez Gene)
KRAS2GeneProduct3845 (Entrez Gene)
KRT17GeneProduct3872 (Entrez Gene)
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PAK1GeneProduct5058 (Entrez Gene)
PEBP1GeneProduct5037 (Entrez Gene)
PIK3C2BGeneProduct5287 (Entrez Gene)
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PRKCMGeneProduct5587 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTK6GeneProduct5753 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN12GeneProduct5782 (Entrez Gene)
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PTPRRGeneProduct5801 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
RAB5AGeneProduct5868 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RALBGeneProduct5899 (Entrez Gene)
RALBP1GeneProduct10928 (Entrez Gene)
RALGDSGeneProduct5900 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RBBP7GeneProduct5931 (Entrez Gene)
REPS1GeneProduct85021 (Entrez Gene)
REPS2GeneProduct9185 (Entrez Gene)
RFXANKGeneProduct8625 (Entrez Gene)
RGS16GeneProduct6004 (Entrez Gene)
RIPK1GeneProduct8737 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
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RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
SH2D3CGeneProduct10044 (Entrez Gene)
SH3BGRLGeneProduct6451 (Entrez Gene)
SH3GL2GeneProduct6456 (Entrez Gene)
SH3GL3GeneProduct6457 (Entrez Gene)
SH3KBP1GeneProduct30011 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SHOC2GeneProduct8036 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SNCAGeneProduct6622 (Entrez Gene)
SNRPD2GeneProduct6633 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
SPRY2GeneProduct10253 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
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STAT2GeneProduct6773 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
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STAT5BGeneProduct6777 (Entrez Gene)
STXBP1GeneProduct6812 (Entrez Gene)
TGIFGeneProduct7050 (Entrez Gene)
TNIP1GeneProduct10318 (Entrez Gene)
TNK2GeneProduct10188 (Entrez Gene)
USP6NLGeneProduct9712 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
VAV2GeneProduct7410 (Entrez Gene)
VAV3GeneProduct10451 (Entrez Gene)
WASLGeneProduct8976 (Entrez Gene)
WNK1GeneProduct65125 (Entrez Gene)
YWHABGeneProduct7529 (Entrez Gene)
ZNF259GeneProduct8882 (Entrez Gene)

Annotated Interactions

No annotated interactions
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