TNF-alpha and mucus production in lung epythelium (Rattus norvegicus)

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1Lung epithel cellProteasomeLPSMucine 2/5ACBDREIL6Nucleusp50TNFR1SOSGrb2RafTlr4ShcMEKTnfaIKBaNemoIl6EGFRSp1NF-kBTgfaRipk2IKKbIKKapp90 rskMuc2NF-kBp65Muc5acTraddMuc2Traf2p50ERKp65Muc5acRas


Description

The upregulation of mucine is regulated by three different pathways which result in the activation of NF-kB.

After TNF-alpha activated its receptor and recruited several adaptor proteins the IKK complex is activated to inhibit IKBa, resulting in the activation and translocation into the nucleus of NF-kB and upregulation of mucine and IL-6. After EGFR activation by TGF-alpha binding the RAS-MAPK-pp90 RSK pathway leads to inactivation of IKBa and thus to the translocation of NF-kB.

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Ontology Terms

 

Bibliography

  1. Lora JM, Zhang DM, Liao SM, Burwell T, King AM, Barker PA, Singh L, Keaveney M, Morgenstern J, Gutierrez-Ramos JC, Coyle AJ, Fraser CC; ''Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.''; J Biol Chem, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126276view04:26, 20 April 2023EgonwLicense is CCZero
87777view11:07, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
82987view00:40, 17 November 2015Mkutmonfixed unconnected lines
82977view23:47, 16 November 2015Mkutmonfixed outdated identifiers
58946view18:07, 21 February 2013MaintBotUpdated Ensembl data source
41692view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
36248view01:02, 12 March 2010KhanspersModified categories
36152view14:54, 3 March 2010Julia139Modified description
36151view14:51, 3 March 2010Julia139Modified description
36150view14:49, 3 March 2010Julia139Periodical save, work in progress
36149view14:37, 3 March 2010Julia139New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
EGFRGeneProduct24329 (Entrez Gene)
ERKGeneProduct116590 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
IKBaGeneProductENSRNOG00000007390 (Ensembl Rat)
IKKaGeneProduct309361 (Entrez Gene)
IKKbGeneProduct84351 (Entrez Gene)
Il6GeneProduct24498 (Entrez Gene)
MEKGeneProduct170851 (Entrez Gene)
Muc2GeneProduct24572 (Entrez Gene)
Muc5acGeneProduct682837 (Entrez Gene)
NF-kBGeneProduct81736 (Entrez Gene)
NemoGeneProduct309295 (Entrez Gene)
RafGeneProduct24703 (Entrez Gene)
RasGeneProductPF00071 (Pfam)
Ripk2GeneProduct362491 (Entrez Gene)
SOSGeneProduct313845 (Entrez Gene)
ShcGeneProduct85385 (Entrez Gene)
Sp1GeneProduct24790 (Entrez Gene)
TNFR1GeneProduct25625 (Entrez Gene)
TgfaGeneProduct24827 (Entrez Gene)
Tlr4GeneProduct29260 (Entrez Gene)
TnfaGeneProduct24835 (Entrez Gene)
TraddGeneProduct246756 (Entrez Gene)
Traf2GeneProduct311786 (Entrez Gene)
p50GeneProduct81736 (Entrez Gene)
p65GeneProduct309165 (Entrez Gene)
pp90 rskGeneProduct117269 (Entrez Gene)

Annotated Interactions

No annotated interactions

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