Non-homologous end joining (Sus scrofa)

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XRCC5XLFLigase VNbs1 ?XRCC5XRCC5XRCC6XRCC4RAD50PRKDCXRCC6PRKDCNHEJ1MRE11APRKDCXRCC6PRKDCXRCC6Ligase VXRCC5XRCC6PRKDCXRCC5XRCC6XRCC5PRKDCXRCC5XRCC6XRCC4XRCC5XRCC6PRKDCPRKDCXRCC6XRCC5XRCC6XRCC5


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r35395) with a 89% conversion rate.

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Quality Tags

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Bibliography

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History

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CompareRevisionActionTimeUserComment
87946view13:05, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87944view13:04, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
68429view18:54, 5 July 2013MaintBotUpdated to 2013 gpml schema
58999view20:01, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41927view05:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
37708view19:26, 28 June 2010MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Ligase VGeneProduct
MRE11AGeneProductENSSSCG00000014955 (Ensembl Pig)
NHEJ1GeneProductENSSSCG00000016205 (Ensembl Pig)
Nbs1 ?GeneProduct
PRKDCGeneProductENSSSCG00000006274 (Ensembl Pig)
RAD50GeneProductENSSSCG00000014280 (Ensembl Pig)
XLFGeneProduct
XRCC4GeneProductENSSSCG00000014135 (Ensembl Pig)
XRCC5GeneProductENSSSCG00000016177 (Ensembl Pig)
XRCC6GeneProductENSSSCG00000000059 (Ensembl Pig)

Annotated Interactions

No annotated interactions
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