Folate-alcohol and cancer pathway hypotheses (Homo sapiens)

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5-Methyl THFCysteineFolateMethionine synthaseMethionine synthase reductaseTHFMethyltransferasesFolate receptors↑CREBDNANON-COMPETITIVEINHIBITIONNUCLEUSNucleotide synthesisMethylated DNASAH5,10-Methylene-THFSAMCYP2E1MTHFRCYP2E1ADHALDH1A1↑ALDH1A1ALDH1L1Methionine↑ALDH1L1↑C/EBPBAcetateHomocysteineCBS↑AcetaldehydeEthanolCystathionine


Description

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Ontology Terms

 

Bibliography

  1. Hwang PH, Lian L, Zavras AI; ''Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.''; Med Hypotheses, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126399view15:33, 26 April 2023EgonwLicense is CCZero
122870view10:14, 27 May 2022EgonwMade a pathway clickable
117726view12:34, 22 May 2021EweitzModified title
106697view13:04, 17 September 2019MaintBotHMDB identifier normalization
96101view23:23, 15 February 2018AlexanderPicoOntology Term : 'oral cavity cancer' added !
96100view23:22, 15 February 2018AlexanderPicoModified description
96099view23:15, 15 February 2018AlexanderPicoModified title
96098view23:14, 15 February 2018AlexanderPicoclarified layout and interations; added MTR
92113view18:55, 28 April 2017EgonwRemoved a lone metabolite node.
87508view01:49, 25 July 2016AlexanderPicoOntology Term : 'cancer pathway' added !
87507view01:49, 25 July 2016AlexanderPicoOntology Term : 'disease pathway' added !
82223view03:26, 16 September 2015AlexanderPicofixed catalysis for biopax conversion
78797view13:00, 30 January 2015EgonwAdded missing metabolite identifiers.
78796view12:51, 30 January 2015EgonwConnected dots.
74018view13:36, 22 March 2014EgonwAdded a few metabolite identifiers.
62366view23:57, 27 April 2013AlexanderPicoFixed gene and metabolite annotations
45285view19:11, 7 October 2011AlexanderPicoadded nucleus
45284view19:10, 7 October 2011AlexanderPicofixed reactions
45282view19:08, 7 October 2011AlexanderPicofixed gene labels
41113view23:36, 1 March 2011MaintBotRemoved redundant pathway information and comments
38167view22:39, 20 August 2010KhanspersAdded xrefs
38166view22:24, 20 August 2010KhanspersAdded xrefs
38165view22:21, 20 August 2010KhanspersPeriodical save, work in progress
38164view22:11, 20 August 2010KhanspersPeriodical save, work in progress
38163view22:00, 20 August 2010KhanspersPeriodical save, work in progress
38147view19:01, 17 August 2010KhanspersModified categories
37896view19:18, 13 July 2010WhomNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB)
ADHGeneProduct
ALDH1A1GeneProduct216 (Entrez Gene)
ALDH1L1GeneProduct10840 (Entrez Gene)
AcetateMetabolite
CBSGeneProduct875 (Entrez Gene)
CYP2E1GeneProduct1571 (Entrez Gene)
CystathionineMetaboliteHMDB00099 (HMDB)
EthanolMetaboliteHMDB00108 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
MTHFRGeneProduct4524 (Entrez Gene)
MethionineMetaboliteHMDB00696 (HMDB)
SAHGeneProduct
SAMGeneProduct
↑ALDH1A1GeneProduct216 (Entrez Gene)
↑ALDH1L1GeneProduct10840 (Entrez Gene)
↑AcetaldehydeMetaboliteHMDB00990 (HMDB)
↑C/EBPBGeneProduct1051

Annotated Interactions

No annotated interactions

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