Matrix metalloproteinases (Homo sapiens)
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Description
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.
Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.
Source: WikipediaQuality Tags
Ontology Terms
Bibliography
- Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia
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