Mouse ESC Pluripotency Pathways (Mus musculus)

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TR Transcriptional Regulation-p DephosphorylationG12 SignalingPIP2Promotes self-renewal (inhibits differentiation)+pRAFERK+pTR+pb BindingR-Smad/ Co-SmadPI3 Kinase / Akt signalingGPCR-Arrestin Signals+pSelf-renewalPI3 kinaseInhibits self-renewal (promotes differentiation)JNKbSelf-renewal+pGi SignalingMEKNucleus+p PhosphorylationLIF SignalingWnt signalingPIP2TRb-pNucleusTcf/LefCa++PKCBMP signalingPIP3R-Smad / Co-Smad complexPDESelf-renewalRas-GTPbDegradation of beta-cateninRas-GDP+pnon-canonical pathway+pFrizzled ligands+pSelf-renewal+pRas/ERK 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


Description

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Comments

GenMAPP notes 
Based on Intracellular Signaling Pathways Regulating Pluripotency of Embryonic Stem Cells, Okita et al, Current Stem Cell Research and Therapy, 2006, 1, 103-111
GenMAPP remarks 
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Bibliography


History

CompareRevisionActionTimeUserComment
42944view07:25, 23 May 2011ThomasDeleted pathway: Duplicate of WP339, no response from author on why this version has additional value.
41268view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
39569view15:08, 23 December 2010SaibrahiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acvr1GeneProduct11477 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Akt2GeneProduct11652 (Entrez Gene)
Akt3GeneProduct23797 (Entrez Gene)
ApcGeneProduct11789 (Entrez Gene)
ArafGeneProduct11836 (Entrez Gene)
Arrb1GeneProduct109689 (Entrez Gene)
Arrb2GeneProduct216869 (Entrez Gene)
Axin1GeneProduct12005 (Entrez Gene)
Bmp4GeneProduct12159 (Entrez Gene)
Bmpr1aGeneProduct12166 (Entrez Gene)
Bmpr1bGeneProduct12167 (Entrez Gene)
Bmpr2GeneProduct12168 (Entrez Gene)
BrafGeneProduct109880 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Dvl1GeneProduct13542 (Entrez Gene)
Dvl2GeneProduct13543 (Entrez Gene)
Dvl3GeneProduct13544 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
ElkGeneProduct270190 (Entrez Gene)
ErasGeneProduct353283 (Entrez Gene)
Fgf10GeneProduct14165 (Entrez Gene)
Fgf11GeneProduct14166 (Entrez Gene)
Fgf1GeneProduct14164 (Entrez Gene)
Fgf12GeneProduct14167 (Entrez Gene)
Fgf13GeneProduct14168 (Entrez Gene)
Fgf14GeneProduct14169 (Entrez Gene)
Fgf15GeneProduct14170 (Entrez Gene)
Fgf16GeneProduct80903 (Entrez Gene)
Fgf17GeneProduct14171 (Entrez Gene)
Fgf18GeneProduct14172 (Entrez Gene)
Fgf20GeneProduct80857 (Entrez Gene)
Fgf2GeneProduct14173 (Entrez Gene)
Fgf21GeneProduct56636 (Entrez Gene)
Fgf22GeneProduct67112 (Entrez Gene)
Fgf23GeneProduct64654 (Entrez Gene)
Fgf3GeneProduct14174 (Entrez Gene)
Fgf4GeneProduct14175 (Entrez Gene)
Fgf5GeneProduct14176 (Entrez Gene)
Fgf6GeneProduct14177 (Entrez Gene)
Fgf7GeneProduct14178 (Entrez Gene)
Fgf8GeneProduct14179 (Entrez Gene)
Fgf9GeneProduct14180 (Entrez Gene)
Fgfr1GeneProduct14182 (Entrez Gene)
Fgfr2GeneProduct14183 (Entrez Gene)
Fgfr3GeneProduct14184 (Entrez Gene)
Fgfr4GeneProduct14186 (Entrez Gene)
FosGeneProduct14281 (Entrez Gene)
Frap1GeneProduct56717 (Entrez Gene)
Fzd1GeneProduct14362 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
Fzd3GeneProduct14365 (Entrez Gene)
Fzd4GeneProduct14366 (Entrez Gene)
Fzd5GeneProduct14367 (Entrez Gene)
Fzd6GeneProduct14368 (Entrez Gene)
Fzd7GeneProduct14369 (Entrez Gene)
Fzd8GeneProduct14370 (Entrez Gene)
Fzd9GeneProduct14371 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Il6stGeneProduct16195 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Lef1GeneProduct21405 (Entrez Gene)
LifGeneProduct16878 (Entrez Gene)
LifrGeneProduct16880 (Entrez Gene)
Lrp5GeneProduct16973 (Entrez Gene)
Lrp6GeneProduct16974 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map2k3GeneProduct26397 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
Map2k6GeneProduct26399 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Mapk12GeneProduct29857 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk4GeneProduct225724 (Entrez Gene)
Mapk6GeneProduct50772 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Mdm2GeneProduct17246 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
NanogGeneProduct71950 (Entrez Gene)
NlkGeneProduct18099 (Entrez Gene)
Oct3/4GeneProduct18999 (Entrez Gene)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
PdgfraGeneProduct18595 (Entrez Gene)
PdgfrbGeneProduct18596 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
PtenGeneProduct19211 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
Smad1GeneProduct17125 (Entrez Gene)
Smad4GeneProduct17128 (Entrez Gene)
Smad5GeneProduct17129 (Entrez Gene)
Smad6GeneProduct17130 (Entrez Gene)
Smad7GeneProduct17131 (Entrez Gene)
Smad9GeneProduct55994 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
Sox2GeneProduct20674 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Tcf1GeneProduct21405 (Entrez Gene)
Tcf2GeneProduct21410 (Entrez Gene)
Tcf3GeneProduct21415 (Entrez Gene)
Tcf4GeneProduct21413 (Entrez Gene)
Wnt10aGeneProduct22409 (Entrez Gene)
Wnt10bGeneProduct22410 (Entrez Gene)
Wnt11GeneProduct22411 (Entrez Gene)
Wnt1GeneProduct22408 (Entrez Gene)
Wnt16GeneProduct93735 (Entrez Gene)
Wnt2GeneProduct22413 (Entrez Gene)
Wnt2bGeneProduct22414 (Entrez Gene)
Wnt3GeneProduct22415 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
Wnt4GeneProduct22417 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
Wnt5bGeneProduct22419 (Entrez Gene)
Wnt6GeneProduct22420 (Entrez Gene)
Wnt7aGeneProduct22421 (Entrez Gene)
Wnt7bGeneProduct22422 (Entrez Gene)
Wnt9bGeneProduct22412 (Entrez Gene)
actr2GeneProduct
actr2bGeneProduct

Annotated Interactions

No annotated interactions
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