Transport of vitamins, nucleosides, and related molecules (Homo sapiens)

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28515-182515422, 2392411, 1220, 212419, 106, 726, 2733-373819194393, 813, 1411, 124029-3220, 21Golgi lumenendoplasmic reticulum lumenlysosomal lumencytosolligands of SLC29A1vitamins transported by SMVTUDP-Gal transporter substratesUDP-xylosesodium ionLong chain fatty acidsAcetyl-coenzyme A transporter 1SLCO3A1UMPGMPligands of SLC28A3UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporterUMPSLCO2B1CMP-sialic acidSLCO3A1 substratesSLCO2B1 substratesPAPSAcetyl-CoAPGTPGT substratesGMPLong chain fatty acidsT3/T4 hormonesUDP-glucuronic acidCMP-sialic acid transportervitamins transported by SMVTUDP-glucuronic acidPAPSSLC28A3PAPST1UDP-xyloseGDP-alpha-D-mannoseSLCO3A1 substratesSLC29A1SLCO4C1PAPligands of SLC29A2ligands of SLC28A3ligands of SLC29A4sodium ionUMPligands of SLC29A4sodium ionAcetyl-CoAcytidine 5'-monophosphateligands of SLC29A3ligands of SLC28A1sodium ionSLCO2B1 substratesFUCT1YEA4ligands of SLC28A2ligands of SLC29A2Thyroid hormone transporting SLCOsdigoxinUDP-Gal transporter substratesdigoxinsodium ionPAPUMPUDP-GlcNAcUMPUDP-sugar substrates of SLC35D2CMP-sialic acidUMPcytidine 5'-monophosphateT3/T4 hormonesSLC28A2SMVTPGT substratesGDP-L-fucoseUDP-GlcNAcEquilibrative nucleoside transporter 3YEA4UDP-sugar substrates of SLC35D2GDP-L-fucoseligands of SLC28A2UDP-galactose translocatorUDP-N-acetylglucosamine transporterligands of SLC29A3SLC29A2ligands of SLC29A1UDP-glucuronate transporter homohexamerFATP1/4/6SLC28A1sodium ionGDP-alpha-D-mannoseEquilibrative nucleoside transporter 4ligands of SLC28A143251


Description

This pathway groups the processes mediated by SLC transporters, by which vitamins and cofactors, as well as nucleosides, nucleotides, nucleobases, and related molecules cross lipid bilayer membranes.

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Ontology Terms

 

Bibliography

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  1. Ishida N, Yoshioka S, Chiba Y, Takeuchi M, Kawakita M.; ''Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter.''; PubMed Europe PMC Scholia
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  3. Perdomo G, Kim DH, Zhang T, Qu S, Thomas EA, Toledo FG, Slusher S, Fan Y, Kelley DE, Dong HH.; ''A role of apolipoprotein D in triglyceride metabolism.''; PubMed Europe PMC Scholia
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  7. Fiore C, Trézéguet V, Le Saux A, Roux P, Schwimmer C, Dianoux AC, Noel F, Lauquin GJ, Brandolin G, Vignais PV.; ''The mitochondrial ADP/ATP carrier: structural, physiological and pathological aspects.''; PubMed Europe PMC Scholia
  8. Segawa H, Kawakita M, Ishida N.; ''Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose.''; PubMed Europe PMC Scholia
  9. Yang CY, Gu ZW, Blanco-Vaca F, Gaskell SJ, Yang M, Massey JB, Gotto AM, Pownall HJ.; ''Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.''; PubMed Europe PMC Scholia
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  12. Perdomo G, Henry Dong H.; ''Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging.''; PubMed Europe PMC Scholia
  13. Lin P, Li J, Liu Q, Mao F, Li J, Qiu R, Hu H, Song Y, Yang Y, Gao G, Yan C, Yang W, Shao C, Gong Y.; ''A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42).''; PubMed Europe PMC Scholia
  14. Grzyb J, Latowski D, Strzałka K.; ''Lipocalins - a family portrait.''; PubMed Europe PMC Scholia
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  16. Molho-Pessach V, Lerer I, Abeliovich D, Agha Z, Abu Libdeh A, Broshtilova V, Elpeleg O, Zlotogorski A.; ''The H syndrome is caused by mutations in the nucleoside transporter hENT3.''; PubMed Europe PMC Scholia
  17. Suda T, Kamiyama S, Suzuki M, Kikuchi N, Nakayama K, Narimatsu H, Jigami Y, Aoki T, Nishihara S.; ''Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.''; PubMed Europe PMC Scholia
  18. Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A.; ''Characterization of a heart-specific fatty acid transport protein.''; PubMed Europe PMC Scholia
  19. Fitscher BA, Riedel HD, Young KC, Stremmel W.; ''Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4).''; PubMed Europe PMC Scholia
  20. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H.; ''Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.''; PubMed Europe PMC Scholia
  21. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG.; ''A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.''; PubMed Europe PMC Scholia
  22. Newman LE, Zhou CJ, Mudigonda S, Mattheyses AL, Paradies E, Marobbio CM, Kahn RA.; ''The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.''; PubMed Europe PMC Scholia
  23. Lu R, Kanai N, Bao Y, Schuster VL.; ''Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT).''; PubMed Europe PMC Scholia
  24. Huber RD, Gao B, Sidler Pfändler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ, Stieger B.; ''Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.''; PubMed Europe PMC Scholia
  25. Crawford CR, Patel DH, Naeve C, Belt JA.; ''Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line.''; PubMed Europe PMC Scholia
  26. Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD.; ''Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1).''; PubMed Europe PMC Scholia
  27. Martinez-Duncker I, Dupré T, Piller V, Piller F, Candelier JJ, Trichet C, Tchernia G, Oriol R, Mollicone R.; ''Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter.''; PubMed Europe PMC Scholia
  28. Ashikov A, Routier F, Fuhlrott J, Helmus Y, Wild M, Gerardy-Schahn R, Bakker H.; ''The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.''; PubMed Europe PMC Scholia
  29. Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ.; ''Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.''; PubMed Europe PMC Scholia
  30. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ.; ''Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.''; PubMed Europe PMC Scholia
  31. Miura N, Ishida N, Hoshino M, Yamauchi M, Hara T, Ayusawa D, Kawakita M.; ''Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator.''; PubMed Europe PMC Scholia
  32. Ishida N, Kuba T, Aoki K, Miyatake S, Kawakita M, Sanai Y.; ''Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.''; PubMed Europe PMC Scholia
  33. Handford M, Rodriguez-Furlán C, Orellana A.; ''Nucleotide-sugar transporters: structure, function and roles in vivo.''; PubMed Europe PMC Scholia
  34. Bailey LK, Campbell LJ, Evetts KA, Littlefield K, Rajendra E, Nietlispach D, Owen D, Mott HR.; ''The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function.''; PubMed Europe PMC Scholia
  35. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A.; ''Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.''; PubMed Europe PMC Scholia
  36. Barnes K, Dobrzynski H, Foppolo S, Beal PR, Ismat F, Scullion ER, Sun L, Tellez J, Ritzel MW, Claycomb WC, Cass CE, Young JD, Billeter-Clark R, Boyett MR, Baldwin SA.; ''Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.''; PubMed Europe PMC Scholia
  37. Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T.; ''Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.''; PubMed Europe PMC Scholia
  38. Griffiths M, Beaumont N, Yao SY, Sundaram M, Boumah CE, Davies A, Kwong FY, Coe I, Cass CE, Young JD, Baldwin SA.; ''Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.''; PubMed Europe PMC Scholia
  39. Muraoka M, Kawakita M, Ishida N.; ''Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity.''; PubMed Europe PMC Scholia
  40. Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V.; ''Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter.''; PubMed Europe PMC Scholia
  41. Stahl A, Hirsch DJ, Gimeno RE, Punreddy S, Ge P, Watson N, Patel S, Kotler M, Raimondi A, Tartaglia LA, Lodish HF.; ''Identification of the major intestinal fatty acid transport protein.''; PubMed Europe PMC Scholia
  42. Kamiyama S, Sasaki N, Goda E, Ui-Tei K, Saigo K, Narimatsu H, Jigami Y, Kannagi R, Irimura T, Nishihara S.; ''Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.''; PubMed Europe PMC Scholia
  43. Ozeran JD, Westley J, Schwartz NB.; ''Identification and partial purification of PAPS translocase.''; PubMed Europe PMC Scholia
  44. Kamiyama S, Suda T, Ueda R, Suzuki M, Okubo R, Kikuchi N, Chiba Y, Goto S, Toyoda H, Saigo K, Watanabe M, Narimatsu H, Jigami Y, Nishihara S.; ''Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter.''; PubMed Europe PMC Scholia
  45. Fischer J, Kleinau G, Müller A, Kühnen P, Zwanziger D, Kinne A, Rehders M, Moeller LC, Führer D, Grüters A, Krude H, Brix K, Biebermann H.; ''Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.''; PubMed Europe PMC Scholia
  46. Lübke T, Marquardt T, Etzioni A, Hartmann E, von Figura K, Körner C.; ''Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency.''; PubMed Europe PMC Scholia
  47. Klingenberg M.; ''Molecular aspects of the adenine nucleotide carrier from mitochondria.''; PubMed Europe PMC Scholia
  48. Visser WE, Philp NJ, van Dijk TB, Klootwijk W, Friesema EC, Jansen J, Beesley PW, Ianculescu AG, Visser TJ.; ''Evidence for a homodimeric structure of human monocarboxylate transporter 8.''; PubMed Europe PMC Scholia
  49. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B.; ''Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.''; PubMed Europe PMC Scholia
  50. Ritzel MW, Ng AM, Yao SY, Graham K, Loewen SK, Smith KM, Ritzel RG, Mowles DA, Carpenter P, Chen XZ, Karpinski E, Hyde RJ, Baldwin SA, Cass CE, Young JD.; ''Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).''; PubMed Europe PMC Scholia
  51. Duee ED, Vignais PV.; ''[Exchange between extra- and intramitochondrial adenine nucleotides].''; PubMed Europe PMC Scholia
  52. De Marcos Lousa C, Trézéguet V, Dianoux AC, Brandolin G, Lauquin GJ.; ''The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.''; PubMed Europe PMC Scholia
  53. Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM.; ''Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.''; PubMed Europe PMC Scholia
  54. Li K, Warner CK, Hodge JA, Minoshima S, Kudoh J, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Wallace DC.; ''A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed.''; PubMed Europe PMC Scholia
  55. Ishida N, Miura N, Yoshioka S, Kawakita M.; ''Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.''; PubMed Europe PMC Scholia
  56. Nabokina SM, Subramanian VS, Said HM.; ''Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter.''; PubMed Europe PMC Scholia
  57. Zhang T, Li S, Zhang Y, Zhong C, Lai Z, Ding J.; ''Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.''; PubMed Europe PMC Scholia
  58. Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA.; ''FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells.''; PubMed Europe PMC Scholia
  59. Flower DR, North AC, Attwood TK.; ''Structure and sequence relationships in the lipocalins and related proteins.''; PubMed Europe PMC Scholia
  60. Hagenbuch B, Meier PJ.; ''Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.''; PubMed Europe PMC Scholia
  61. Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T.; ''Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.''; PubMed Europe PMC Scholia
  62. Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD.; ''Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.''; PubMed Europe PMC Scholia
  63. Pfaff E, Klingenberg M, Heldt HW.; ''Unspecific permeation and specific exchange of adenine nucleotides in liver mitochondria.''; PubMed Europe PMC Scholia
  64. Loewen SK, Ng AM, Yao SY, Cass CE, Baldwin SA, Young JD.; ''Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114879view16:39, 25 January 2021ReactomeTeamReactome version 75
113325view11:39, 2 November 2020ReactomeTeamReactome version 74
112536view15:50, 9 October 2020ReactomeTeamReactome version 73
101449view11:32, 1 November 2018ReactomeTeamreactome version 66
100987view21:10, 31 October 2018ReactomeTeamreactome version 65
100523view19:44, 31 October 2018ReactomeTeamreactome version 64
100070view16:28, 31 October 2018ReactomeTeamreactome version 63
99621view15:00, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99228view12:44, 31 October 2018ReactomeTeamreactome version 62
94041view13:53, 16 August 2017ReactomeTeamreactome version 61
93665view11:30, 9 August 2017ReactomeTeamreactome version 61
86787view09:26, 11 July 2016ReactomeTeamreactome version 56
83207view10:22, 18 November 2015ReactomeTeamVersion54
81588view13:07, 21 August 2015ReactomeTeamVersion53
77048view08:34, 17 July 2014ReactomeTeamFixed remaining interactions
76753view12:11, 16 July 2014ReactomeTeamFixed remaining interactions
76078view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75788view11:31, 10 June 2014ReactomeTeamReactome 48 Update
75138view14:08, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74785view08:52, 30 April 2014ReactomeTeamReactome46
45060view19:59, 6 October 2011KhanspersOntology Term : 'transport pathway' added !
42152view22:00, 4 March 2011MaintBotAutomatic update
39963view05:58, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acetyl-CoA Metabolite15351 (ChEBI)
Acetyl-coenzyme A

transporter 1

ProteinO00400 (UniProt)
CMP-sialic acid Metabolite16556 (ChEBI)
CMP-sialic acid

transporter

ProteinP78382 (UniProt)
Equilibrative

nucleoside transporter 3

ProteinQ9BZD2 (UniProt)
Equilibrative

nucleoside transporter 4

ProteinQ7RTT9 (UniProt)
FATP1/4/6 UnknownREACT_24174 (Reactome)
FUCT1 ProteinQ96A29 (UniProt)
GDP-L-fucose Metabolite17009 (ChEBI)
GDP-alpha-D-

mannose

Metabolite15820 (ChEBI)
GMP Metabolite17345 (ChEBI)
Long chain fatty

acids

MetaboliteREACT_24406 (Reactome)
Long chain fatty

acids

MetaboliteREACT_24650 (Reactome)
PAP Metabolite17985 (ChEBI)
PAPS Metabolite17980 (ChEBI)
PAPST1 ProteinQ8TB61 (UniProt)
PGT ProteinQ92959 (UniProt)
PGT substrates MetaboliteREACT_24629 (Reactome)
PGT substrates MetaboliteREACT_24713 (Reactome)
SLC28A1 ProteinO00337 (UniProt)
SLC28A2 ProteinO43868 (UniProt)
SLC28A3 ProteinQ9HAS3 (UniProt)
SLC29A1 ProteinQ99808 (UniProt)
SLC29A2 ProteinQ14542 (UniProt)
SLCO2B1 ProteinO94956 (UniProt)
SLCO2B1 substrates MetaboliteREACT_24278 (Reactome)
SLCO2B1 substrates MetaboliteREACT_24748 (Reactome)
SLCO3A1 ProteinQ9UIG8-1 (UniProt)
SLCO3A1 substrates ProteinREACT_24656 (Reactome)
SLCO3A1 substrates MetaboliteREACT_24849 (Reactome)
SLCO4C1 ProteinQ6ZQN7 (UniProt)
SMVT ProteinQ9Y289 (UniProt)
T3/T4 hormones MetaboliteREACT_24262 (Reactome)
T3/T4 hormones MetaboliteREACT_24702 (Reactome)
Thyroid hormone

transporting SLCOs

ProteinREACT_24523 (Reactome)
UDP-Gal transporter

substrates

MetaboliteREACT_22450 (Reactome)
UDP-Gal transporter

substrates

MetaboliteREACT_22484 (Reactome)
UDP-GlcNAc Metabolite16264 (ChEBI)
UDP-N-

acetylglucosamine transporter

ProteinQ9Y2D2 (UniProt)
UDP-N-

acetylglucosamine/U DP-glucose/GDP- mannose transporter

ProteinQ76EJ3 (UniProt)
UDP-galactose

translocator

ProteinP78381 (UniProt)
UDP-glucuronate

transporter homohexamer

ComplexREACT_7361 (Reactome)
UDP-glucuronic

acid

Metabolite17200 (ChEBI)
UDP-sugar

substrates of SLC35D2

MetaboliteREACT_23127 (Reactome)
UDP-sugar substrates

of SLC35D2

MetaboliteREACT_23247 (Reactome)
UDP-xylose Metabolite16082 (ChEBI)
UMP Metabolite16695 (ChEBI)
YEA4 ProteinQ969S0 (UniProt)
cytidine 5'-

monophosphate

Metabolite17361 (ChEBI)
digoxin Metabolite4551 (ChEBI)
ligands of SLC28A1 MetaboliteREACT_8051 (Reactome)
ligands of SLC28A1 MetaboliteREACT_8344 (Reactome)
ligands of SLC28A2 MetaboliteREACT_8398 (Reactome)
ligands of SLC28A2 MetaboliteREACT_8955 (Reactome)
ligands of SLC28A3 MetaboliteREACT_8379 (Reactome)
ligands of SLC28A3 MetaboliteREACT_8767 (Reactome)
ligands of SLC29A1 MetaboliteREACT_8358 (Reactome)
ligands of SLC29A1 MetaboliteREACT_8580 (Reactome)
ligands of SLC29A2 MetaboliteREACT_8574 (Reactome)
ligands of SLC29A2 MetaboliteREACT_8842 (Reactome)
ligands of SLC29A3 MetaboliteREACT_22517 (Reactome)
ligands of SLC29A3 MetaboliteREACT_22952 (Reactome)
ligands of SLC29A4 MetaboliteREACT_23205 (Reactome)
ligands of SLC29A4 MetaboliteREACT_23305 (Reactome)
sodium ion Metabolite29101 (ChEBI)
vitamins transported by

SMVT

MetaboliteREACT_22987 (Reactome)
vitamins transported by

SMVT

MetaboliteREACT_23003 (Reactome)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1937"
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