IL-5 signaling pathway (Bos taurus)

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DMTLigandDDDDephosphorylationCY->NUDDDesumoylationDCY->NUProteins in a complex interactionDCY->NUENTranslocationPalmitoylationDGOMitochondriaEndoplasmic reticulumInhibitionDDProteolytic cleavageNUPM->NUGolgi apparatusAcetylationMolecular associationDEndosomeReceptorCYReaction through unknown mechanisms/moleculesUbiquitination(Protein-protein interaction)PMDGlycosylationDPM->NUMethylationDeubiquitinationAutophosphorylationPlasma membraneRecruitmentExtracellularAccession Number: NetPath 17NucleusSumoylationCY->PMControlCytoplasmEREnzyme complexMolecule in the pathwayPM->NUDeacetylationDGene SymbolActivationDDemethylationCY->MTDPhosphorylationECDRAP1GAPDNM2BTKCDKN1BPIM1CSF2RBALOX5APSTAT5BRAC1PTK2BSHC1HCKJAK2PIK3CGPRKCBSHC2JUNHCLS1ITGAMVAV1PRKCDHRASSOCS1CTNNB1MAPK14PTPN11RAPGEF1STAT5ANFKBIAYWHAZIL5ELK1CRKLMAPK3GSK3ACRKLICAM3CBLUNC119JAK1IL2RBSH2B2ITGB2STAT3MAPK1STAT5BSOX4FOXO3ATF2MAP2K2KRASPRKCDBAXICAM1BAXGRB2CSF2RBAKT1NFKB1NFKB1SDCBPSTAT5AALOX5SYKCSF2RBPIK3R1ALOX5IL5RARPS6KA1IL5RARAF1PTPN6LYNMAPK9CCND3STAT1PLA2G4AGSK3BIL5CTNNB1PIK3R2


Description

No description

Comments

GenMAPP notes 
NetPath 17 - IL-5 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP127(r20949) with a 93% conversion rate.

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117540view11:15, 21 May 2021EweitzModified title
115937view08:11, 21 March 2021EgonwCopied the NetPath paper into the literature list
115934view08:09, 21 March 2021EgonwModified description
111048view12:34, 3 July 2020L DupuisConverted interactions to graphical lines in legend
80918view15:31, 30 June 2015Mkutmonhomology conversion
63386view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
40559view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33797view00:15, 9 December 2009MaintBotAutomatic update of empty xrefs
31629view22:21, 13 August 2009MaintBotFixed text labels
30537view21:55, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
ALOX5GeneProduct404074 (Entrez Gene)
ALOX5APGeneProduct613869 (Entrez Gene)
ATF2GeneProduct509827 (Entrez Gene)
BAXGeneProduct785708 (Entrez Gene)
BTKGeneProduct533459 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CCND3GeneProduct540547 (Entrez Gene)
CDKN1BGeneProduct512613 (Entrez Gene)
CRKLGeneProduct
CSF2RBGeneProduct528530 (Entrez Gene)
CTNNB1GeneProduct539003 (Entrez Gene)
DNM2GeneProduct511691 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
FOXO3GeneProduct535530 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GSK3AGeneProduct536561 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
HCKGeneProduct280814 (Entrez Gene)
HCLS1GeneProduct508445 (Entrez Gene)
HRASGeneProduct513012 (Entrez Gene)
ICAM1GeneProduct281839 (Entrez Gene)
ICAM3GeneProduct281840 (Entrez Gene)
IL2RBGeneProduct510185 (Entrez Gene)
IL5GeneProduct280825 (Entrez Gene)
IL5RAGeneProduct615848 (Entrez Gene)
ITGAMGeneProduct407124 (Entrez Gene)
ITGB2GeneProduct281877 (Entrez Gene)
JAK1GeneProduct537201 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
KRASGeneProduct541140 (Entrez Gene)
LYNGeneProduct534996 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
NFKBIAGeneProduct282291 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PIM1GeneProduct281402 (Entrez Gene)
PLA2G4AGeneProduct525072 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PTK2BGeneProduct541008 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAP1GAPGeneProduct532839 (Entrez Gene)
RAPGEF1GeneProduct520454 (Entrez Gene)
RPS6KA1GeneProduct533908 (Entrez Gene)
SDCBPGeneProduct510979 (Entrez Gene)
SH2B2GeneProduct617840 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SHC2GeneProduct533455 (Entrez Gene)
SOCS1GeneProduct518795 (Entrez Gene)
SOX4GeneProduct768313 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
SYKGeneProduct515515 (Entrez Gene)
UNC119GeneProduct538501 (Entrez Gene)
VAV1GeneProduct617345 (Entrez Gene)
YWHAZGeneProduct287022 (Entrez Gene)

Annotated Interactions

No annotated interactions
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