Translation factors (Bos taurus)
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43S Pre-initiation Complex
Recruitment of 60S subunit
and first peptide bond
40S Subunit
AUG
mRNA
Elongation
Cap Binding Complex
Termination
scanning
Translocation
60S Subunit
AAAAAAAAAAAAAAA
Binds aminoacyl-tRNA
Initiation
m7G
Recruitment of 43S
Pre-initiation Complex
Guanine Nucleotide Exchange
EIF5
EIF4A1
EIF4B
EIF4EBP3
EIF3F
EIF4E
EEF2
EIF1
EEF1B2
EIF4EBP2
EIF3H
EIF3S8
EIF3D
GSPT2
WBSCR1
EIF2B2
EIF1AY
EEF2K
EIF4G3
PABPC1
EIF2B4
PAIP1
EIF2S3
EIF1AX
EEF1A2
EIF5A
EIF4EBP1
EEF1D
EIF3B
EIF2B3
EIF4G1
EEF1A1
EIF3I
EIF2S1
EIF2AK2
EIF1
EIF3J
EIF2AK1
EIF2B1
LOC531049
EIF3A
ETF1
EIF2AK3
EIF5B
EIF2B5
EIF3G
EIF6
EIF4A2
EEF1G
EIF2S2
EIF3E
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP107(r29787)
with a 90% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Dever TE; ''Gene-specific regulation by general translation factors.''; Cell, 2002
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117628
view
11:44, 21 May 2021
Eweitz
Modified title
80725
view
15:23, 30 June 2015
Mkutmon
homology conversion
63460
view
17:18, 10 May 2013
MaintBot
Updated to 2013 gpml schema
40595
view
19:33, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33832
view
00:29, 9 December 2009
MaintBot
Automatic update of empty xrefs
33614
view
10:00, 1 December 2009
MaintBot
Removed group label
31627
view
22:21, 13 August 2009
MaintBot
Fixed text labels
30534
view
21:54, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
EEF1A1
GeneProduct
282220 (Entrez Gene)
EEF1A2
GeneProduct
515233 (Entrez Gene)
EEF1B2
GeneProduct
520875 (Entrez Gene)
EEF1D
GeneProduct
516473 (Entrez Gene)
EEF1G
GeneProduct
326581 (Entrez Gene)
EEF2
GeneProduct
281138 (Entrez Gene)
EEF2K
GeneProduct
521730 (Entrez Gene)
EIF1
GeneProduct
509764 (Entrez Gene)
EIF1AX
GeneProduct
511189 (Entrez Gene)
EIF1AY
GeneProduct
100271756 (Entrez Gene)
EIF2AK1
GeneProduct
507689 (Entrez Gene)
EIF2AK2
GeneProduct
347700 (Entrez Gene)
now E2K2 HUMAN
EIF2AK3
GeneProduct
535820 (Entrez Gene)
EIF2B1
GeneProduct
516670 (Entrez Gene)
EIF2B2
GeneProduct
513958 (Entrez Gene)
EIF2B3
GeneProduct
534063 (Entrez Gene)
EIF2B4
GeneProduct
521926 (Entrez Gene)
EIF2B5
GeneProduct
783760 (Entrez Gene)
EIF2S1
GeneProduct
327694 (Entrez Gene)
EIF2S2
GeneProduct
520094 (Entrez Gene)
EIF2S3
GeneProduct
512350 (Entrez Gene)
EIF3A
GeneProduct
506564 (Entrez Gene)
EIF3B
GeneProduct
789999 (Entrez Gene)
EIF3D
GeneProduct
515226 (Entrez Gene)
EIF3E
GeneProduct
534165 (Entrez Gene)
EIF3F
GeneProduct
513793 (Entrez Gene)
EIF3G
GeneProduct
615695 (Entrez Gene)
EIF3H
GeneProduct
506873 (Entrez Gene)
EIF3I
GeneProduct
521747 (Entrez Gene)
EIF3J
GeneProduct
539052 (Entrez Gene)
EIF3S8
GeneProduct
EIF4A1
GeneProduct
504958 (Entrez Gene)
EIF4A2
GeneProduct
286819 (Entrez Gene)
EIF4B
GeneProduct
505850 (Entrez Gene)
EIF4E
GeneProduct
281751 (Entrez Gene)
EIF4EBP1
GeneProduct
509613 (Entrez Gene)
EIF4EBP2
GeneProduct
782397 (Entrez Gene)
EIF4EBP3
GeneProduct
EIF4G1
GeneProduct
TrEMBL accession number O43177 refers to same protein.
EIF4G3
GeneProduct
534618 (Entrez Gene)
EIF5
GeneProduct
504752 (Entrez Gene)
EIF5A
GeneProduct
444990 (Entrez Gene)
EIF5B
GeneProduct
532850 (Entrez Gene)
EIF6
GeneProduct
286811 (Entrez Gene)
ETF1
GeneProduct
541077 (Entrez Gene)
GSPT2
GeneProduct
538724 (Entrez Gene)
LOC531049
GeneProduct
531049 (Entrez Gene)
PABPC1
GeneProduct
282296 (Entrez Gene)
PAIP1
GeneProduct
510246 (Entrez Gene)
WBSCR1
GeneProduct
Annotated Interactions
No annotated interactions
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Discussion
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Annotated Interactions
No annotated interactions