DNA replication (Canis familiaris)

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1-3Mcm2Mcm10Mcm5Orc complexMcm3DNA polymerase alpha:primase: origin complexRFC Heteropentamer:RNA primer-DNA primerGemininMcm54. Switching of origins to post-replicative statep49Cdt1Orc5Orc complexRFC405. Leading/lagging strand synthesisOrc3Orc4Mcm22. Activation of the pre-replicative complexp58RNA primer-DNA primer:origin duplex:PCNAOrc3Cdc6p70Orc complexMcm3PrimaseProcessive complexp180RNA primer-DNA primerOrc4Orc complexMcm4Phosphorylated Cdc6Ubiquitinated Cdc6Pre-replicative complexMcm4Phosphorylated Orc1Mcm 4,6,7 trimer forms andassociates with the replication forkCdt1DNA polymerase alpha:primase: origin complexOrc5Mcm6Phosphorylation ofMcm 2-7 complexRFC140Cdt1Orc5Degraded byproteasomein cytosol3. DNA replication initiationOrc2Cdt1Cdt1Mcm7Orc complexOrc3RFC38OriginMcm10Orc1UbiquitinOrc2Degraded by proteasome in cytosolRNA PrimerDNAPolymerase ACdc6Mcm61. Assembly of the pre-replicative complexCdc6Ubiquitinated Orc1Mcm7RFC36RNA primer-DNA primerCdc6RFC37RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc2Pre-replicative complexOrc2Orc3UbiquitinUBA52PRIM2POLEPOLD1RPA3RPA2MCM2ATPPRIM1MCM10UTPPCNAADPGMNNORC1LORC3LMCM3POLA1GTPPOLA2MCM4ATPdUTPCDC6CDC45LRFC5ORC5LdATPdCTPMCM5CDT1ATPRFC2ADPATPORC2LPOLD4RPA1MCM7dGTPPOLD3RFC4RFC1MCM6CDC7DBF4ORC6LPOLD2RPA4CDK2RFC3UBCCTPPOLE2ORC4L


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 74% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117444view10:52, 21 May 2021EweitzModified title
71479view19:18, 17 October 2013MaintBotAutomated update of data sources
68572view22:58, 5 July 2013MaintBotUpdated to 2013 gpml schema
67157view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40730view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35221view15:53, 11 February 2010Thomasadded literature
35207view15:43, 11 February 2010ThomasModified description
34009view18:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32545view13:04, 17 August 2009MaintBotFixed text labels
32227view12:48, 15 August 2009MaintBotFixed text labels
31728view11:57, 14 August 2009MaintBotFixed group labels
31243view19:49, 13 August 2009MaintBotFixed text labels
30670view22:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct486421 (Entrez Gene)
CDC6GeneProduct480527 (Entrez Gene)
CDC7GeneProduct479955 (Entrez Gene)
CDK2GeneProduct606931 (Entrez Gene)
CDT1GeneProduct479616 (Entrez Gene)
CTPMetabolite
DBF4GeneProduct475219 (Entrez Gene)
GMNNGeneProduct478739 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct487128 (Entrez Gene)
MCM2GeneProduct484622 (Entrez Gene)
MCM3GeneProduct481839 (Entrez Gene)
MCM4GeneProduct477871 (Entrez Gene)
MCM5GeneProduct610519 (Entrez Gene)
MCM6GeneProduct476131 (Entrez Gene)
MCM7GeneProduct479737 (Entrez Gene)
ORC1LGeneProduct475351 (Entrez Gene)
ORC2LGeneProduct478868 (Entrez Gene)
ORC3LGeneProduct474991 (Entrez Gene)
ORC4LGeneProduct476141 (Entrez Gene)
ORC5LGeneProduct609937 (Entrez Gene)
ORC6LGeneProduct482492 (Entrez Gene)
PCNAGeneProduct477166 (Entrez Gene)
POLA1GeneProduct480869 (Entrez Gene)
POLA2GeneProduct476025 (Entrez Gene)
POLD1GeneProduct610047 (Entrez Gene)
POLD2GeneProduct482686 (Entrez Gene)
POLD3GeneProduct476806 (Entrez Gene)
POLD4GeneProduct611847 (Entrez Gene)
POLE2GeneProduct608973 (Entrez Gene)
POLEGeneProduct486223 (Entrez Gene)
PRIM1GeneProduct607309 (Entrez Gene)
PRIM2GeneProduct474950 (Entrez Gene)
RFC1GeneProduct479112 (Entrez Gene)
RFC2GeneProduct489798 (Entrez Gene)
RFC3GeneProduct477308 (Entrez Gene)
RFC4GeneProduct478667 (Entrez Gene)
RFC5GeneProduct477499 (Entrez Gene)
RPA1GeneProduct491196 (Entrez Gene)
RPA2GeneProduct487339 (Entrez Gene)
RPA3GeneProduct481449 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct403722 (Entrez Gene)
UBCGeneProduct610457 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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