IL5 signaling (Homo sapiens)

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DMTLigandDDDDephosphorylationCY->NUDDDesumoylationDCY->NUProteins in a complex interactionDCY->NUENTranslocationPalmitoylationDGOMitochondriaEndoplasmic reticulumInhibitionDDProteolytic cleavageNUPM->NUGolgi apparatusAcetylationMolecular associationDEndosomeReceptorCYReaction through unknown mechanisms/moleculesUbiquitination(Protein-protein interaction)PMDGlycosylationDPM->NUMethylationDeubiquitinationAutophosphorylationPlasma membraneRecruitmentExtracellularAccession Number: NetPath 17NucleusSumoylationCY->PMControlCytoplasmEREnzyme complexMolecule in the pathwayPM->NUDeacetylationDGene SymbolActivationDDemethylationCY->MTDPhosphorylationECDRAP1GAPDNM2BTKCDKN1BPIM1CSF2RBALOX5APSTAT5BRAC1PTK2BSHC1HCKJAK2PIK3CGPRKCB1SHC2JUNHCLS1ITGAMVAV1PRKCDHRASSOCS1CTNNB1MAPK14PTPN11RAPGEF1STAT5ANFKBIAYWHAZIL5ELK1CRKLMAPK3GSK3ACRKLICAM3CBLUNC119JAK1IL2RBAPSITGB2STAT3MAPK1STAT5BSOX4FOXO3AATF2MAP2K2KRASPRKCDBAXICAM1BAXGRB2CSF2RBAKT1NFKB1NFKB1SDCBPSTAT5AALOX5SYKCSF2RBPIK3R1ALOX5IL5RARPS6KA1IL5RARAF1PTPN6LYNMAPK9CCND3STAT1PLA2G4AGSK3BIL5CTNNB1PIK3R2


Description

Interleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain which is shared between all members of this cytokine family. Binding of IL-5 to IL5RA recruits the beta chain to the complex, this then activates the JAK/STAT and Raf/MAPK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_17

Comments

GenMAPP notes 
NetPath 17 - IL-5 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135258view11:14, 9 August 2024EweitzRefine legend, node alignment
135257view11:10, 9 August 2024EweitzEconomize layout
135256view11:02, 9 August 2024EweitzRefine legend, economize layout
135255view10:56, 9 August 2024EweitzEconomize layout
129702view01:29, 22 May 2024EweitzModified title
126270view16:18, 19 April 2023EgonwLicense is CCZero
120669view01:18, 23 December 2021EweitzStandardize font, weight, case
116634view11:22, 9 May 2021EweitzModified title
115944view07:11, 22 March 2021EgonwModified description
108326view21:07, 6 December 2019L DupuisConverted interactions to graphical lines in legend
78498view10:28, 7 January 2015MaintBotadded missing graphIds
70017view01:50, 12 July 2013AlexanderPicoModified title
68063view17:57, 29 June 2013MaintBotOntology Term : 'DOID:4' removed !
67853view12:34, 27 June 2013Noopur144Ontology Term : 'Disease' added !
67380view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-5 signaling pathway' added !
64648view15:03, 31 May 2013AndraAdded reference from the description in the pathway
63212view20:58, 8 May 2013MaintBotUpdating gpml version
48438view14:36, 24 May 2012NetPathModified description
45368view20:59, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45132view00:52, 7 October 2011AlexanderPicofixed db refs
44847view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44626view18:05, 22 September 2011KhanspersUpdating content to NetSlim
44104view20:23, 24 August 2011KhanspersReverted to version '23:13, 1 March 2011' by Khanspers
44021view22:48, 22 August 2011KhanspersAdded category
44020view22:48, 22 August 2011KhanspersModified description
44019view22:46, 22 August 2011KhanspersUpdating pathway from NetSlim
41029view23:13, 1 March 2011MaintBotRemoved redundant pathway information and comments
35644view21:34, 12 February 2010KhanspersModified description
20949view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-5 NetPath 17]] moved to [[Pathway:WP127]]: Moved to stable identifier
8182view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-5 NetPath 17]] moved to [[Pathway:Homo sapiens:IL-5 NetPath 17]]: Renaming species
7711view16:12, 18 December 2007MaintBotfixed category names
7250view12:41, 4 November 2007MaintBotAdded categories to GPML
6338view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-5_NetPath_17]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
ALOX5GeneProduct240 (Entrez Gene)
ALOX5APGeneProduct241 (Entrez Gene)
APSGeneProduct10603 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BTKGeneProduct695 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CSF2RBGeneProduct1439 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
DNM2GeneProduct1785 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HCKGeneProduct3055 (Entrez Gene)
HCLS1GeneProduct3059 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
ICAM3GeneProduct3385 (Entrez Gene)
IL2RBGeneProduct3560 (Entrez Gene)
IL5GeneProduct3567 (Entrez Gene)
IL5RAGeneProduct3568 (Entrez Gene)
ITGAMGeneProduct3684 (Entrez Gene)
ITGB2GeneProduct3689 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIM1GeneProduct5292 (Entrez Gene)
PLA2G4AGeneProduct5321 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAP1GAPGeneProduct5909 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
SDCBPGeneProduct6386 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SHC2GeneProduct25759 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOX4GeneProduct6659 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
SYKGeneProduct6850 (Entrez Gene)
UNC119GeneProduct9094 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
YWHAZGeneProduct7534 (Entrez Gene)

Annotated Interactions

No annotated interactions
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