Angiogenesis (Homo sapiens)

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PDGF:PDGFRAng-1':Tie2'Ang-1@default|activePKC''r260FRP@defaultSPK'|activePaxillin'|activeCrk'|activeCrkPIP2'r140Axin'r224Grb2c-Fos@Nuclear membrane'Raf''FVIIa@defaultp38MAPK'|activeAPC:Axin:GSK3_beta_Akt''''|activer226r289MEKCaspase 9'r225r233_beta__space_catenin'r295Dsh'JAK1r300r284Raf'|activePLC-_gamma_RacMEKK1''PakFAK'''|activeSrcEts@Nuclear membrane'''r259HIF-1@Nuclear membrane'|activeTCF@Nuclear membrane'r181Erk''JAK1'''|activeRasGAPr188PIP3PI3K'''''Delta/Serrate:Notch:PARMAPKAPK2/3r291re108c-Fos:c-Jun|active@Nuclear membraner175Ras'''''|activec-Fos':c-Jun'|active@Nuclear membrane'CSL@Nuclear membrane'|activeNckCaspase 9'''|activeEts@Nuclear membrane'|activeMEKK1'''|activer207MEK'|activeMAPKAPK2/3'|activeJNK1''r232Shp-2'r249r223Akt''SPKTF@defaultr222FRS-2Notchr261BAD''|activere115re109r268STAT1@Nuclear membrane'|activeDsh|activeAPCr189re110Src'|activeRas''''|activeSTAT3@Nuclear membrane'''|activeErk'''PKC'|activeVRAPVEGFR-2cPLA_sub_2_endsubNck'|activer157r288r152Ras''STAT3@Nuclear membraneCa_super_2+_endsuper''_beta__space_catenin|activeDelta/Serrate@defaultp38MAPKCa_super_2+_endsuper@ERFzdGrb2'|activer221GRB2'|activeShp-2'''|activeJNK1'''|activer205r178PI3K'''''''|activePLD|activePLC-_gamma_''BADr190PLA_sub_2_endsub|activeGrb14'|activer179JNK1'|activeCa_super_2+_endsuper're114DAG'VEGF:VEGFR-2SurvivinHSP27'|activeMEK''r276Ets@Nuclear membrane''r279re113Ang-1:Tie2|active'MEK''''|activere105r254re111Dok-RFGFR-1IP3Ras'|activer153Eph:EphRr177r182Caspase 9|activer285IP3'r248PARTCF@Nuclear membrane|activer220r146r263Ras'''Ca_super_2+_endsuper:cPLA_sub_2_endsubr296CSL@Nuclear membraneCa_super_2+_endsuper':eNOS'|activeFGF:FGFR-1PLC-_gamma_'''|activeHSP27r186JAK1''r293Ets@Nuclear membrane''''|activer287c-Fos@Nuclear membraner237Rac'|activer155MEKK1'|activeErkr244FAKSTAT3@Nuclear membrane'|activeJNK1r256r281Tie2FRS-2'|activePI3K'''EphRAkt|activeVRAP'|activer250r283Raf''''|activeVEGF@defaultPDGF@defaultr176JNKK1'|activeAng-2@defaultr278JNKK1'''|activeDAGr147r204PI3K''''Wnt@default'c-Jun@Nuclear membrane''JAK1'|activeVE-PTPDok-R'|activer292MEK'''''|activeErk'''''|activer262r230r294r252STAT1@Nuclear membrane|activer274STAT3@Nuclear membrane''r267PLD'r299Ca_super_2+_endsuper:eNOS|active'Ets@Nuclear membraneGRB2SOS-1'|activeEts@Nuclear membrane'''''|activec-Jun@Nuclear membrane'|activer151r297r202STAT1@Nuclear membrane''Shp-2''|activec-Jun@Nuclear membraner290Raf'''r245Grb7re106MEK'''r247r154PDGFRPI3K|activeGAP'PLA_sub_2_endsub'PI3K''''''|activeAPC'PLC-_gamma_'|activer234PIP2FAK're107Raf'''''|activeAkt'''Sck'|activeErk''''|activeAxineNOS'Fzd:Wntr280r246SOS-1FAK''|activeSurvivin'|activeRafAng-1@default'r301Rasr156r275Akt'''''|activeeNOSBAD'|activeGTPaseSTAT1@Nuclear membrane'''SHCr231GSK3_beta_JNKK1''r203PI3K''|activeSrc''Erk'|activeAkt'BAD'''c-Jun@Nuclear membrane'''|activer282Paxillinr269Wnt@defaultFGF@defaultSHC'|activer270PKCCaspase 9''RasGAP'|activeShp-2r145JNKK1r174r277Grb14GTPase'|activePI3K'IP3@ERPak'|activer271r206PKC'''|activeCa_super_2+_endsuper'''r255r286r183MEKK1r180SckGrb7'|activer253Src'''|activer272Eph@defaultCa_super_2+_endsuperGAP|activeHIF-1@Nuclear membrane


Description

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Quality Tags

Ontology Terms

 

Bibliography


History

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CompareRevisionActionTimeUserComment
62233view17:32, 26 April 2013MaintBotDeleted pathway: abandoned pathway
44953view12:37, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to development' added !
44463view18:40, 14 September 2011MaintBotModified categories
41227view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
39435view16:57, 30 November 2010PietNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APC'
APC:Axin:GSK3_beta_
APC
Akt'''''|active
Akt''''|active
Akt'''
Akt''
Akt'
Akt|active
Ang-1':Tie2'
Ang-1:Tie2|active'
Ang-1@default'
Ang-1@default|active
Ang-2@default
Axin'
Axin
BAD'''
BAD''|active
BAD'|active
BAD
CSL@Nuclear membrane'|active
CSL@Nuclear membrane
Ca_super_2+_endsuper'''
Ca_super_2+_endsuper''
Ca_super_2+_endsuper':eNOS'|active
Ca_super_2+_endsuper'
Ca_super_2+_endsuper:cPLA_sub_2_endsub
Ca_super_2+_endsuper:eNOS|active'
Ca_super_2+_endsuper@ER
Ca_super_2+_endsuper
Caspase 9'''|active
Caspase 9''
Caspase 9'
Caspase 9|active
Crk'|active
Crk
DAG'
DAG
Delta/Serrate:Notch:PAR
Delta/Serrate@default
Dok-R'|active
Dok-R
Dsh'
Dsh|active
Eph:EphR
Eph@default
EphR
Erk'''''|active
Erk''''|active
Erk'''
Erk''
Erk'|active
Erk
Ets@Nuclear membrane'''''|active
Ets@Nuclear membrane''''|active
Ets@Nuclear membrane'''
Ets@Nuclear membrane''
Ets@Nuclear membrane'|active
Ets@Nuclear membrane
FAK'''|active
FAK''|active
FAK'
FAK
FGF:FGFR-1
FGF@default
FGFR-1
FRP@default
FRS-2'|active
FRS-2
FVIIa@default
Fzd:Wnt
Fzd
GAP'
GAP|active
GRB2'|active
GRB2
GSK3_beta_
GTPase'|active
GTPase
Grb14'|active
Grb14
Grb2'|active
Grb2
Grb7'|active
Grb7
HIF-1@Nuclear membrane'|active
HIF-1@Nuclear membrane
HSP27'|active
HSP27
IP3'
IP3@ER
IP3
JAK1'''|active
JAK1''
JAK1'|active
JAK1
JNK1'''|active
JNK1''
JNK1'|active
JNK1
JNKK1'''|active
JNKK1''
JNKK1'|active
JNKK1
MAPKAPK2/3'|active
MAPKAPK2/3
MEK'''''|active
MEK''''|active
MEK'''
MEK''
MEK'|active
MEKK1'''|active
MEKK1''
MEKK1'|active
MEKK1
MEK
Nck'|active
Nck
Notch
PAR
PDGF:PDGFR
PDGF@default
PDGFR
PI3K'''''''|active
PI3K''''''|active
PI3K'''''
PI3K''''
PI3K'''
PI3K''|active
PI3K'
PI3K|active
PIP2'
PIP2
PIP3
PKC'''|active
PKC''
PKC'|active
PKC
PLA_sub_2_endsub'
PLA_sub_2_endsub|active
PLC-_gamma_'''|active
PLC-_gamma_''
PLC-_gamma_'|active
PLC-_gamma_
PLD'
PLD|active
Pak'|active
Pak
Paxillin'|active
Paxillin
Rac'|active
Rac
Raf'''''|active
Raf''''|active
Raf'''
Raf''
Raf'|active
Raf
Ras'''''|active
Ras''''|active
Ras'''
Ras''
Ras'|active
RasGAP'|active
RasGAP
Ras
SHC'|active
SHC
SOS-1'|active
SOS-1
SPK'|active
SPK
STAT1@Nuclear membrane'''
STAT1@Nuclear membrane''
STAT1@Nuclear membrane'|active
STAT1@Nuclear membrane|active
STAT3@Nuclear membrane'''|active
STAT3@Nuclear membrane''
STAT3@Nuclear membrane'|active
STAT3@Nuclear membrane
Sck'|active
Sck
Shp-2'''|active
Shp-2''|active
Shp-2'
Shp-2
Src'''|active
Src''
Src'|active
Src
Survivin'|active
Survivin
TCF@Nuclear membrane'
TCF@Nuclear membrane|active
TF@default
Tie2
VE-PTP
VEGF:VEGFR-2
VEGF@default
VEGFR-2
VRAP'|active
VRAP
Wnt@default'
Wnt@default
_beta__space_catenin'
_beta__space_catenin|active
c-Fos':c-Jun'|active@Nuclear membrane'
c-Fos:c-Jun|active@Nuclear membrane
c-Fos@Nuclear membrane'
c-Fos@Nuclear membrane
c-Jun@Nuclear membrane'''|active
c-Jun@Nuclear membrane''
c-Jun@Nuclear membrane'|active
c-Jun@Nuclear membrane
cPLA_sub_2_endsub
eNOS'
eNOS
p38MAPK'|active
p38MAPK
r140
r145
r146
r147
r151
r152
r153
r154
r155
r156
r157
r174
r175
r176
r177
r178
r179
r180
r181
r182
r183
r186
r188
r189
r190
r202
r203
r204
r205
r206
r207
r220
r221
r222
r223
r224
r225
r226
r230
r231
r232
r233
r234
r237
r244
r245
r246
r247
r248
r249
r250
r252
r253
r254
r255
r256
r259
r260
r261
r262
r263
r267
r268
r269
r270
r271
r272
r274
r275
r276
r277
r278
r279
r280
r281
r282
r283
r284
r285
r286
r287
r288
r289
r290
r291
r292
r293
r294
r295
r296
r297
r299
r300
r301
re105
re106
re107
re108
re109
re110
re111
re113
re114
re115

Annotated Interactions

No annotated interactions

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