Hypothetical network for drug addiction (Pan troglodytes)
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1
Gap junction
Neuroactive ligand-receptor
interaction
NMDAR
AMPAR
Strong depolarization
Long-term potentiation
MAPK signaling pathway
Gonadotropins gene
expression & secretion
Regulation of gap junction
Local Translation
mGluR
Regulation of actin cytoskeleton
GnRH Signal pathway
GRIA4
CAMK2
MAPK3
DRD1
GRIA3
PKC
Ca++
GRIN2B
GJB7
NR1
MAPK1
CAMK4
MAP2K1
PRKACA
ZHX2
D-Glutamate
GRIN2A
DRD4
Gi
GRIA1
PPA1
GJB7
MAP2K2
I-1
RAP1
Gs
DRD2
GRIA2
ADCY1
GRM1
CREB1
GRIN2C
GRIN2D
PRKACA
KRIT1
GRM5
ADCY1
ADCY8
ACTA1
Cyclic AMP
Description
Adapted from figure 2 in
Li et al.
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP666(r29740)
with a 70% conversion rate.
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Quality Tags
Ontology Terms
Saving...
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Bibliography
Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
118081
view
10:44, 24 May 2021
Eweitz
Modified title
107223
view
14:31, 17 September 2019
MaintBot
ChEBI identifier normalization
102312
view
13:33, 18 December 2018
Egonw
Fixed the ChEBI identifier for Ca2+
88659
view
15:15, 12 August 2016
Jmelius
Ontology Term : 'substance dependence disease pathway' added !
69323
view
18:44, 8 July 2013
MaintBot
Updated to 2013 gpml schema
41633
view
02:03, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34360
view
22:26, 9 December 2009
MaintBot
Automatic update of empty xrefs
33537
view
09:36, 1 December 2009
MaintBot
Removed group label
31571
view
21:59, 13 August 2009
MaintBot
Fixed text labels
30442
view
21:23, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ACTA1
GeneProduct
ADCY1
GeneProduct
463392 (Entrez Gene)
ADCY8
GeneProduct
464400 (Entrez Gene)
CAMK2
GeneProduct
CAMK4
GeneProduct
461992 (Entrez Gene)
CREB1
GeneProduct
459901 (Entrez Gene)
Ca++
Metabolite
29320 (ChEBI)
Cyclic AMP
Metabolite
17489 (ChEBI)
D-Glutamate
Metabolite
15966 (ChEBI)
DRD1
GeneProduct
DRD2
GeneProduct
451553 (Entrez Gene)
DRD4
GeneProduct
449578 (Entrez Gene)
GJB7
GeneProduct
742067 (Entrez Gene)
GRIA1
GeneProduct
471714 (Entrez Gene)
GRIA2
GeneProduct
461570 (Entrez Gene)
GRIA3
GeneProduct
GRIA4
GeneProduct
466768 (Entrez Gene)
GRIN2A
GeneProduct
454396 (Entrez Gene)
GRIN2B
GeneProduct
473373 (Entrez Gene)
GRIN2C
GeneProduct
454868 (Entrez Gene)
GRIN2D
GeneProduct
456180 (Entrez Gene)
GRM1
GeneProduct
463049 (Entrez Gene)
GRM5
GeneProduct
451472 (Entrez Gene)
Gi
GeneProduct
Gs
GeneProduct
I-1
GeneProduct
KRIT1
GeneProduct
463528 (Entrez Gene)
MAP2K1
GeneProduct
450188 (Entrez Gene)
MAP2K2
GeneProduct
456390 (Entrez Gene)
MAPK1
GeneProduct
458680 (Entrez Gene)
MAPK3
GeneProduct
454037 (Entrez Gene)
NR1
GeneProduct
PKC
GeneProduct
PPA1
GeneProduct
748973 (Entrez Gene)
PRKACA
GeneProduct
455776 (Entrez Gene)
RAP1
GeneProduct
ZHX2
GeneProduct
464363 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Discussion
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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DataNodes
Annotated Interactions
No annotated interactions