Phase I biotransformations, non-P450 (Rattus norvegicus)

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1OHOHHydrolysisOHOHcarboxylic acid esterscarboxylic acid estersPhosphoric acid estersPhosphoric acid estersamidesCes7thio estersNP_001099521.1Pon2Lip1Pon1Pon3thio estersCES1amidesCES2


Description

This pathway lists several phase 1 biotransformations and their related enzymes. NOTE: This pathway is incomplete, reduction and oxidation enzymes are missing

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP136(r29886) with a 75% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Klaassen, C.D., Watkins III, J.B.; ''Casarett & Doull's Essentials of Toxicology''; , 2003

History

View all...
CompareRevisionActionTimeUserComment
128190view00:34, 29 January 2024EweitzModified title
125275view16:04, 31 January 2023LarsgwAdd ISBN to publication
107231view14:32, 17 September 2019MaintBotChEBI identifier normalization
95802view14:50, 19 January 2018Mkutmonfixed link to parent pathway
95801view14:47, 19 January 2018MkutmonHomology conversion update
73508view23:17, 29 January 2014KhanspersModified title
69378view18:56, 8 July 2013MaintBotUpdated to 2013 gpml schema
67589view11:30, 26 June 2013DdiglesOntology Term : 'cytochrome P450-independent phase I biotransformation pathway' added !
58947view18:08, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41693view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
34078view19:12, 9 December 2009MaintBotAutomatic update of empty xrefs
31892view12:43, 14 August 2009MaintBotFixed group labels
30966view00:47, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CES1GeneProduct
CES2GeneProduct498940 (Entrez Gene)
Ces7GeneProductENSRNOG00000025710 (Ensembl Rat)
Lip1GeneProductENSRNOG00000019077 (Ensembl Rat)
NP_001099521.1GeneProductENSRNOG00000009512 (Ensembl Rat)
Phosphoric acid estersMetabolite
Pon1GeneProductENSRNOG00000008902 (Ensembl Rat)
Pon2GeneProductENSRNOG00000009112 (Ensembl Rat)
Pon3GeneProductENSRNOG00000009096 (Ensembl Rat)
amidesMetabolite32988 (ChEBI)
carboxylic acid estersMetabolite
thio estersMetabolite

Annotated Interactions

No annotated interactions
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