Myometrial relaxation and contraction pathways (Rattus norvegicus)

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1, 2RAMPbeta ArrestinProtein Kinase CPathways of Myometrial ContractionCell GrowthCa2+NOMg2+Calcium InfluxTRLPACa2+Camk2PGbgSignalingGRKbeta ArrestinGRKbeta ArrestinCRE-Transcription FactorsPi + IP3 ReceptorActivation Via CRH and cAMPIP3Ca++/CalmodulinRyrPKC inhibitor Protein-1Protein Kinase APhospholipase-CAP-1 complexRGSMyometrial ContractionRegulators of G-proteinTR = Transcriptional RegulationDAGIP3 ReceptorTRSRGbgPathways of Myometrial RelaxationMlckPge2Calcium MobilizationPKCPKA Inhibitorsnote: see gene backpages for referencesAdenylyl CyclasesPKAPip2CAM-Kinase 2CalmodulinPredicted Cxn43GPCR KinaseRAMPPKC inhibitor 1Myometrial RelaxationAdenylyl CyclasesIGFBPEts complexRyanodine Receptor (Ryr)TranscriptionalRegulatorsIGFBPPredicted OT-RNucleusMAPKGbgNa+Phospholipase-CIgfbp2PrkczGng7PRKAR1AAtf1YWHAQGng12Igfbp4Creb1Cyclic AMPMyl2Pde4dNos1CALCAGuca2bPkigIl6Gng3Cacnb3SfnAtp2a3Actc1Arrb1Gnb2Sp1Rgs20FosGstt2Rgs7MaffPlcg2Rgs2RLN1Prkar2bCxcr7Ramp3Nfkb1GnaqLpar1GNASCrhr1Gja1Plcb3Camk2bAdcy5Actg1Igfbp3DgkzPrkcaActa1Gpr182Mylk2Igfbp6YwhagCreb3Plcg1LOC686059Gsto1Gng8Rgs17GUCY2EATPArrb2PrkchAtf3Rgs1Rgs3Il1bAdcy7MYL4Guca2aPrkcgYwhahCorinPrkacbCALD1CALM3Prkar2aRamp1Rxfp2Gabpb1lGrk6Adcy8GNG2Adcy6Cyclic GMPRYR2Rgs16GNG4Rgs10Camk2aRgs18PrkcbRgs14Rgs4Pde4bAdcy4RYR3PkiaGnb3ADCY9CrhGnb1YwhaeCALM2Itpr2PrkcdYwhabRxfp1Prkar1bPrkcePrkcqOxtrGnb4GabpaADPRgs11Atf5Gngt1Gucy1a3PkibItpr3Igfbp5Itpr1Rgs5CNN2Atf2Camk2dPrkd1ATPRgs6Camk2gEts2CrcpJunGng5AdmAdcy1PrkacaPlcd1Cyclic AMPGrk5Slc8a1Gng11Gnb5Rgs19Nos3Grk4Atp2a2OxtADPRamp2OxtrAtf6bGng13ACTA2Rgs9YwhazAtf4Cnn1Adcy2CALM1Adcy3ActbIgfbp1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP289(r21289) with a 86% conversion rate.

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Bibliography

  1. Aggelidou E, Hillhouse EW, Grammatopoulos DK; ''Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  2. Méhats C, Tanguy G, Dallot E, Cabrol D, Ferré F, Leroy MJ; ''Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium?''; J Clin Endocrinol Metab, 2001 PubMed Europe PMC Scholia
  3. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR; ''Identifying genetic networks underlying myometrial transition to labor.''; Genome Biol, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
122787view00:20, 18 May 2022AlexanderPicocleaning up broken comments
116995view10:54, 16 May 2021EweitzModified title
109394view16:08, 16 March 2020L DupuisFixed interactions
106965view13:42, 17 September 2019MaintBotHMDB identifier normalization
95805view14:53, 19 January 2018MkutmonHomology conversion update
87895view12:52, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
71831view19:37, 18 October 2013MaintBotremoved data source from nodes without identifier
71285view05:02, 17 October 2013MaintBot
69919view19:43, 11 July 2013MaintBotupdated to 2013 schema
69918view19:42, 11 July 2013MaintBotModified description
47773view05:37, 6 April 2012Khanspersupdated xref
41734view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
35261view20:17, 11 February 2010Thomasmoved references from comment to bibliography
34109view19:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32347view13:36, 15 August 2009MaintBotFixed text labels
31970view13:08, 14 August 2009MaintBotFixed group labels
31394view20:47, 13 August 2009MaintBotFixed text labels
30924view00:35, 30 July 2009MaintBotConverted from Homo sapiens
20977view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Smooth muscle contraction]] moved to [[Pathway:WP140]]: Moved to stable identifier
8400view13:46, 7 January 2008MaintBot[[Pathway:Rat:Smooth muscle contraction]] moved to [[Pathway:Rattus norvegicus:Smooth muscle contraction]]: Renaming species
7817view16:19, 18 December 2007MaintBotfixed category names
7490view12:42, 4 November 2007MaintBotAdded categories to GPML
6595view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Smooth_muscle_contraction]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA2GeneProduct81633 (Entrez Gene)
ADCY9GeneProduct302950 (Entrez Gene)
ADPMetabolite
ATPMetabolite
Acta1GeneProduct29437 (Entrez Gene)
ActbGeneProduct81822 (Entrez Gene)
Actc1GeneProduct29275 (Entrez Gene)
Actg1GeneProduct287876 (Entrez Gene)
Adcy1GeneProduct305509 (Entrez Gene) CYA1 HUMAN
Adcy2GeneProduct81636 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy3GeneProduct64508 (Entrez Gene)
Adcy4GeneProduct54223 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy5GeneProduct64532 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy6GeneProduct25289 (Entrez Gene)
Adcy7GeneProduct84420 (Entrez Gene)
Adcy8GeneProduct29241 (Entrez Gene)
AdmGeneProduct25026 (Entrez Gene)
Arrb1GeneProduct25387 (Entrez Gene)
Arrb2GeneProduct25388 (Entrez Gene)
Atf1GeneProduct315305 (Entrez Gene)
Atf2GeneProduct81647 (Entrez Gene)
Atf3GeneProduct25389 (Entrez Gene)
Atf4GeneProduct79255 (Entrez Gene)
Atf5GeneProduct282840 (Entrez Gene)
Atf6bGeneProduct406169 (Entrez Gene)
Atp2a2GeneProduct29693 (Entrez Gene)
Atp2a3GeneProduct25391 (Entrez Gene)
CALCAGeneProduct24241 (Entrez Gene) CRF HUMAN PMID: 11854458
CALD1GeneProduct25687 (Entrez Gene)
CALM1GeneProduct24242 (Entrez Gene)
CALM2GeneProduct50663 (Entrez Gene)
CALM3GeneProduct24244 (Entrez Gene)
CNN2GeneProduct
Cacnb3GeneProduct25297 (Entrez Gene)
Camk2aGeneProduct25400 (Entrez Gene)
Camk2bGeneProduct24245 (Entrez Gene)
Camk2dGeneProduct24246 (Entrez Gene)
Camk2gGeneProduct171140 (Entrez Gene)
Cnn1GeneProduct65204 (Entrez Gene)
CorinGeneProduct289596 (Entrez Gene) MGI:97367
CrcpGeneProduct114205 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
Creb3GeneProduct298400 (Entrez Gene)
CrhGeneProduct81648 (Entrez Gene) CRF HUMAN PMID: 11854458
Crhr1GeneProduct58959 (Entrez Gene)
Cxcr7GeneProduct84348 (Entrez Gene) PMID: 10614663
Cyclic AMPMetaboliteHMDB00058 (HMDB)
Cyclic GMPMetaboliteHMDB01314 (HMDB)
DgkzGeneProduct81821 (Entrez Gene)
Ets2GeneProduct304063 (Entrez Gene)
FosGeneProduct314322 (Entrez Gene) PMID: 10218980 PMID: 7628395 [
GNASGeneProduct24896 (Entrez Gene)
GNG2GeneProduct80850 (Entrez Gene)
GNG4GeneProduct114118 (Entrez Gene)
GUCY2EGeneProduct79222 (Entrez Gene) PMID: 11854458
GabpaGeneProduct363735 (Entrez Gene) Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.

Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.

PMID: 10218980
Gabpb1lGeneProduct364738 (Entrez Gene) Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.

Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.

PMID: 10218980
Gja1GeneProduct24392 (Entrez Gene) Endogenous nitric oxide suppresses rat myometrial connexin 43 gap junction protein expression during pregnancy.

Sladek SM, Westerhausen-Larson A, Roberts JM.

PMID: 10377025
GnaqGeneProduct81666 (Entrez Gene)
Gnb1GeneProduct24400 (Entrez Gene)
Gnb2GeneProduct81667 (Entrez Gene)
Gnb3GeneProduct60449 (Entrez Gene)
Gnb4GeneProduct294962 (Entrez Gene)
Gnb5GeneProduct83579 (Entrez Gene)
Gng11GeneProduct64199 (Entrez Gene)
Gng12GeneProduct114120 (Entrez Gene)
Gng13GeneProduct685451 (Entrez Gene)
Gng3GeneProduct114117 (Entrez Gene)
Gng5GeneProduct79218 (Entrez Gene)
Gng7GeneProduct58979 (Entrez Gene)
Gng8GeneProduct245986 (Entrez Gene)
Gngt1GeneProduct680149 (Entrez Gene)
Gpr182GeneProduct29307 (Entrez Gene)
Grk4GeneProduct59077 (Entrez Gene)
Grk5GeneProduct59075 (Entrez Gene)
Grk6GeneProduct59076 (Entrez Gene)
Gsto1GeneProduct114846 (Entrez Gene)
Gstt2GeneProduct29487 (Entrez Gene)
Guca2aGeneProduct25656 (Entrez Gene)
Guca2bGeneProduct64055 (Entrez Gene)
Gucy1a3GeneProduct497757 (Entrez Gene) PMID: 11854458
Igfbp1GeneProduct25685 (Entrez Gene)
Igfbp2GeneProduct25662 (Entrez Gene)
Igfbp3GeneProduct24484 (Entrez Gene) Relaxin is a member of the Insulin Growth Factor family of proteins. IGFBP-3 binds IGFII preferentially. (SwissProt).
Igfbp4GeneProduct360622 (Entrez Gene)
Igfbp5GeneProduct25285 (Entrez Gene)
Igfbp6GeneProduct25641 (Entrez Gene)
Il1bGeneProduct24494 (Entrez Gene) Structure, characterization, and expression of the rat oxytocin receptor gene.

Rozen F, Russo C, Banville D, Zingg HH PMID: 7816817 quote: The presence of APREs in the OTR gene promoter suggests that the acute induction of OTR expression at the onset of parturition may be a phenomenon mechanistically similar to the fast induction of acute phase response genes. This notion is strengthened by the observation that the uterus is populated by macrophages and other specific lymphocytes (19,20). Specifically, at term, nearly half of the decidual cells are of bone marrow origin (20). IL-1beta released from macrophages stimulates the production and release of IL-6 by uterine stromal cells (21,22). Moreover, IL- is a central pathophysiological mediator of infection-induced premature delivery (23), and preterm delivery can be prevented by an IL-1 antagonist in mice (24). We speculate that under physiological as well as phathophysiological conditions, inflammatory cytokines are important inducers of labor and that this mechanism involves the cytokine-induced transcriptional activation of the OTR gene. :end quote

19. Hunt, J.S. (1994) Biol. Reprod. 50, 461-466 20. Vince, G.S., et al. (1990) J. Immunol. Methods 132, 181-189. 21. Tabibzadeh, S. (1991) Endocr. Rev, 12, 272-290. 22. Dudley, D.Jl, et. Al. (1992) J. Clin. Endocrinol. Metab. 74, 884-889 23. Romero, R., et. Al, Am. J. Obstet. Gynecol. 167, 863-872.

Il6GeneProduct24498 (Entrez Gene) Structure, characterization, and expression of the rat oxytocin receptor gene.

Rozen F, Russo C, Banville D, Zingg HH PMID: 7816817 quote: The presence of APREs in the OTR gene promoter suggests that the acute induction of OTR expression at the onset of parturition may be a phenomenon mechanistically similar to the fast induction of acute phase response genes. This notion is strengthened by the observation that the uterus is populated by macrophages and other specific lymphocytes (19,20). Specifically, at term, nearly half of the decidual cells are of bone marrow origin (20). IL-1beta released from macrophages stimulates the production and release of IL-6 by uterine stromal cells (21,22). Moreover, IL- is a central pathophysiological mediator of infection-induced premature delivery (23), and preterm delivery can be prevented by an IL-1 antagonist in mice (24). We speculate that under physiological as well as phathophysiological conditions, inflammatory cytokines are important inducers of labor and that this mechanism involves the cytokine-induced transcriptional activation of the OTR gene. :end quote

19. Hunt, J.S. (1994) Biol. Reprod. 50, 461-466 20. Vince, G.S., et al. (1990) J. Immunol. Methods 132, 181-189. 21. Tabibzadeh, S. (1991) Endocr. Rev, 12, 272-290. 22. Dudley, D.Jl, et. Al. (1992) J. Clin. Endocrinol. Metab. 74, 884-889 23. Romero, R., et. Al, Am. J. Obstet. Gynecol. 167, 863-872.

Itpr1GeneProduct25262 (Entrez Gene)
Itpr2GeneProduct81678 (Entrez Gene)
Itpr3GeneProduct25679 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene) PMID: 10218980
LOC686059GeneProduct686059 (Entrez Gene)
Lpar1GeneProduct116744 (Entrez Gene)
MYL4GeneProduct
MaffGeneProduct366960 (Entrez Gene) OMIM: Inoue et al. (1994) demonstrated that the US-2 element in the promoter of the human oxytocin receptor gene (OXTR; 167055) binds specifically nuclear proteins from human myometrium at parturition. Using the US-2 element in a yeast 1-hybrid system to screen a human myometrium cDNA library, Kimura et al. (1999) isolated a full-length cDNA encoding the homolog of chicken MafF. Human MAFF encodes a deduced 164-amino acid protein with a predicted molecular mass of 17.8 kD. Like other small MAF proteins (e.g., MAFG, 602020), it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. Northern blot analysis showed a strong 2.6-kb signal in mRNA from term myometrium and from kidney, but not from nonpregnant myometrium. The MAFF protein is also preferentially expressed in term myometrium. The authors concluded that MAFF plays a role in OXTR gene upregulation at term.
Myl2GeneProduct363925 (Entrez Gene)
Mylk2GeneProduct117558 (Entrez Gene) KML2 MOUSE
Nfkb1GeneProduct81736 (Entrez Gene) Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE. PMID: 10421804
Nos1GeneProduct24598 (Entrez Gene) PMID: 11854458
Nos3GeneProduct24600 (Entrez Gene) PMID: 11854458
OxtGeneProduct25504 (Entrez Gene) MGI:97453
OxtrGeneProduct25342 (Entrez Gene)

Sladek SM, Westerhausen-Larson A, Roberts JM.

PMID: 10377025
PRKAR1AGeneProduct25725 (Entrez Gene) KAP0 HUMAN
Pde4bGeneProduct24626 (Entrez Gene)
Pde4dGeneProduct24627 (Entrez Gene)
PkiaGeneProduct114906 (Entrez Gene)
PkibGeneProduct24678 (Entrez Gene)
PkigGeneProduct266709 (Entrez Gene)
Plcb3GeneProduct29322 (Entrez Gene)
Plcd1GeneProduct24655 (Entrez Gene)
Plcg1GeneProduct25738 (Entrez Gene)
Plcg2GeneProduct29337 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
PrkacbGeneProduct293508 (Entrez Gene)
Prkar1bGeneProduct25521 (Entrez Gene)
Prkar2aGeneProduct29699 (Entrez Gene)
Prkar2bGeneProduct24679 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
PrkceGeneProduct29340 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
PrkcgGeneProduct24681 (Entrez Gene)
PrkchGeneProduct81749 (Entrez Gene)
PrkcqGeneProduct85420 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Prkd1GeneProduct85421 (Entrez Gene) KPCM HUMAN
RLN1GeneProduct25616 (Entrez Gene)
RYR2GeneProduct689560 (Entrez Gene)
RYR3GeneProduct170546 (Entrez Gene)
Ramp1GeneProduct58965 (Entrez Gene)
Ramp2GeneProduct58966 (Entrez Gene)
Ramp3GeneProduct56820 (Entrez Gene)
Rgs10GeneProduct54290 (Entrez Gene)
Rgs11GeneProduct54291 (Entrez Gene)
Rgs14GeneProduct114705 (Entrez Gene)
Rgs1GeneProduct54289 (Entrez Gene)
Rgs16GeneProduct360857 (Entrez Gene)
Rgs17GeneProduct308118 (Entrez Gene)
Rgs18GeneProduct289076 (Entrez Gene)
Rgs19GeneProduct59293 (Entrez Gene)
Rgs20GeneProduct362477 (Entrez Gene)
Rgs2GeneProduct84583 (Entrez Gene)
Rgs3GeneProduct54293 (Entrez Gene)
Rgs4GeneProduct29480 (Entrez Gene)
Rgs5GeneProduct54294 (Entrez Gene)
Rgs6GeneProduct54295 (Entrez Gene)
Rgs7GeneProduct54296 (Entrez Gene)
Rgs9GeneProduct29481 (Entrez Gene)
Rxfp1GeneProduct295144 (Entrez Gene) PMID: 11809971
Rxfp2GeneProduct363866 (Entrez Gene) PMID: 11809971 LGR8 MOUSE
SfnGeneProduct313017 (Entrez Gene)
Slc8a1GeneProduct29715 (Entrez Gene)
Sp1GeneProduct24790 (Entrez Gene) Promoter activity of the rat connexin 43 gene in NRK cells.

Fernandez-Cobo M, Stewart D, Drujan D, De Maio A.

Division of Pediatric Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

PMID: 11255234
YWHAQGeneProduct25577 (Entrez Gene)
YwhabGeneProduct56011 (Entrez Gene)
YwhaeGeneProduct29753 (Entrez Gene)
YwhagGeneProduct56010 (Entrez Gene)
YwhahGeneProduct25576 (Entrez Gene)
YwhazGeneProduct25578 (Entrez Gene) PMID: 9861170 PMID: 1317796

Annotated Interactions

No annotated interactions
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