Cholesterol metabolism (Rattus norvegicus)

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1-6StatinSREBP syntheseGenesfatty acid degradationSRE-regionER-membraanHmgcrLipctrans-trans-famesyl-PPCholesterolaceloacetyl CoAVLDLNsdhlMevalonate kinaseSCAP_RATSREBP27-DehydrocholesterolSc4molAcetyl-CoAHmgcs1LathosterollanosterolFdft1(S)-2,3-EpoxysqualeneIDLMvdIsopentenyl pyrophosphateSCAP_RATMevalonic acid-5PHmgcrsc5dlLcatSREBP2HDLDimethylallylpyrophosphateCyp51other gene products involved in cholesterol sythesisScarb1SqleDhcr7LDL Abca1aceloacetyl CoA thiolaseLdlrMevalonic acid-5PPaceloacetyl CoA thiolaseMevalonate kinasePmvkCETPS2pGeranyl pyrophosphateSqualeneHmgcs1low cholesterolMvdLssAcetoacetyl-CoAHMG-CoAFdpsLplSREBP2Mevalonic acidnSREBPnSREBPSREBP1cFdpsPmvkS1p


Description

No description

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Ontology Terms

 

Bibliography

  1. Gadbut AP, Wu L, Tang D, Papageorge A, Watson JA, Galper JB; ''Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins.''; EMBO J, 1997 PubMed Europe PMC Scholia
  2. Wassmann S, Nickenig G; ''Improvement of Endothelial Function by HMG-CoA Reductase Inhibitors.''; Drug News Perspect, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114498view07:34, 18 January 2021EgonwTranslocation
107002view13:46, 17 September 2019MaintBotHMDB identifier normalization
83034view02:57, 18 November 2015Mkutmonfixed issue with literature reference
83033view02:56, 18 November 2015Mkutmonfix outdated identifiers and improved layout
77527view17:45, 22 September 2014KhanspersOntology Term : 'arterial occlusive disease pathway' added !
72578view16:02, 23 November 2013EgonwReplace a revoked HMDB id with a ChEBI id.
69457view19:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
69093view18:11, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
67117view10:08, 26 June 2013Christine ChichesterOntology Term : 'cholesterol metabolic pathway' added !
58977view18:46, 21 February 2013MaintBotUpdated Ensembl data source
48279view23:30, 17 May 2012KhanspersUpdating PubChem xrefs
48268view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45002view15:52, 6 October 2011Mkutmonconnecting lines
41788view02:43, 2 March 2011MaintBotRemoved redundant pathway information and comments
34153view19:37, 9 December 2009MaintBotAutomatic update of empty xrefs
33394view14:45, 30 November 2009MaintBotRemoved group label
29751view23:02, 1 June 2009KhanspersFixed literature references
29748view22:55, 1 June 2009KhanspersModified categories
28543view14:58, 11 February 2009I450472Specify description
28486view13:34, 11 February 2009I450472Periodical save, work in progress
28477view13:23, 11 February 2009I450472Periodical save, work in progress
28469view13:13, 11 February 2009I450472Periodical save, work in progress
28459view13:03, 11 February 2009I450472Periodical save, work in progress
28452view12:53, 11 February 2009I450472Periodical save, work in progress
28441view12:43, 11 February 2009I450472Periodical save, work in progress
28431view12:33, 11 February 2009I450472Periodical save, work in progress
28422view12:23, 11 February 2009I450472Periodical save, work in progress
28415view12:13, 11 February 2009I450472Periodical save, work in progress
28406view12:02, 11 February 2009I450472Periodical save, work in progress
28399view11:52, 11 February 2009I450472Periodical save, work in progress
28391view11:37, 11 February 2009442798Periodical save, work in progress
28389view11:27, 11 February 2009442798Periodical save, work in progress
28366view10:27, 11 February 2009442798Periodical save, work in progress
28346view10:17, 11 February 2009442798Periodical save, work in progress
28242view14:42, 10 February 2009SusanNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetabolite439382 (PubChem)
7-DehydrocholesterolMetabolite439423 (PubChem)
Abca1GeneProduct313210 (Entrez Gene)
Acetoacetyl-CoAMetaboliteHMDB01484 (HMDB)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
CETPGeneProduct
CholesterolMetabolite5997 (PubChem)
Cyp51GeneProduct25427 (Entrez Gene)
Dhcr7GeneProduct64191 (Entrez Gene)
DimethylallylpyrophosphateMetabolite647 (PubChem)
Fdft1GeneProduct29580 (Entrez Gene)
FdpsGeneProduct83791 (Entrez Gene)
Geranyl pyrophosphateMetabolite445995 (PubChem)
HDLMetabolite
HMG-CoAMetaboliteHMDB01375 (HMDB)
HmgcrGeneProduct25675 (Entrez Gene)
Hmgcs1GeneProduct29637 (Entrez Gene)
IDLGeneProduct
Isopentenyl pyrophosphateMetaboliteHMDB01347 (HMDB)
LDL Metabolite
LathosterolMetabolite65728 (PubChem)
LcatGeneProduct24530 (Entrez Gene)
LdlrGeneProduct300438 (Entrez Gene)
LipcGeneProduct24538 (Entrez Gene)
LplGeneProduct24539 (Entrez Gene)
LssGeneProduct81681 (Entrez Gene)
Mevalonate kinaseMetabolite
Mevalonic acid-5PMetabolite439400 (PubChem)
Mevalonic acid-5PPMetabolite
Mevalonic acidMetabolite439230 (PubChem)
MvdGeneProduct81726 (Entrez Gene)
NsdhlGeneProduct309262 (Entrez Gene)
PmvkGeneProduct310645 (Entrez Gene)
S1pGeneProduct89842 (Entrez Gene)
S2pGeneProduct25013 (Entrez Gene)
SCAP_RATGeneProductENSRNOG00000020853 (Ensembl Rat)
SREBP1cGeneProduct
SREBP2GeneProduct300095 (Entrez Gene)
Sc4molGeneProduct620281 (Entrez Gene)
Scarb1GeneProduct25073 (Entrez Gene)
SqleGeneProduct29230 (Entrez Gene)
SqualeneMetabolite1105 (PubChem)
VLDLMetabolite
aceloacetyl CoAMetabolite
aceloacetyl CoA thiolaseGeneProduct
lanosterolMetabolite
low cholesterolGeneProduct
nSREBPGeneProduct
other gene products involved in cholesterol sythesisGeneProduct
sc5dlGeneProduct114100 (Entrez Gene)
trans-trans-famesyl-PPMetabolite

Annotated Interactions

No annotated interactions

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