L1CAM interactions (Homo sapiens)

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1-525-271416, 2021-232837, 383213309-1234, 3519, 323329143683918, 197, 318244015333214, 16, 17extracellular regionclathrin-coated endocytic vesiclecytosolnucleoplasmendosomecytosolAxonin-1Neuropilin-1L1:FGFR1synapse-associated proteins (SAP)ADPL1:HNK-1pL1:CK-IIpL1:EzrinGDPATPPAK1 dimer (inactive/autoinhibited)L1:NCAM1 complexPAK1AnkyrinsNeurofascin:CNTN1:CASPR complexCHL1ATPADPNCAM1GTPNeurofascin:NrCAM:Ankyrin:spectrin based actin:Na+/K+ channelNrCAM:Ankyrin-GHeat Stable Antigen (HSA)Neuropilin-1ATPL1-EGFR trans-heterodimerunidentified protein tyrosine kinaseOrthophosphatepPAK1:Rac1-GTPNeuropilin-2 (NP2)ATPTyr phos L1:EPHB2p90rskATPCRMP-2:NUMB:alpha adaptinADPunidentified protein tyrosine kinaseEGFRSyntenin-1Neurofascin:NrCAM:Ankyrin:spectrin based actinspectrin based actinADPNeurofascinphospho-ERK-1:MEK1Neurofascin:Ankyrin-G complexATPHsc70NrCAM:NP-2CHL1:alpha1beta1/alpha2beta1 integrinsRAC1-GDPpL1:ERM:F-actinATPF-actinNrCAMALCAMShootin-1CHL1:CNTN6L1:AP-2 Clathrin complexContactin-6pNFASC:DoublecortinL1 trans-homodimerpL1 (Y1176)L1:NP-1ADPADPActivated ERK2Neurofascin:Syntenin-1 complexAnkyrin-GADPunknown proteinmicrotubuleMEK2:ERK-2Dynamin-1/2/3L1 dimer:Ankyrin:Spectrin:F-actinGDPMEK1:ERK-1DoublecortinTrans neurofascin dimer:ankyrin-GAP2 clathrin:L1:KIF4:microtubuleAxonin-1IntegrinsADPpL1 (S1204, 1248):ERK2:clathrin-dynamin complexADPL1:Axonin-1OrthophosphatepL1:Shootin-1:F-actinATPCHL1:Ankyrin-GL1:CNTN1RanBPML1:HSACasein kinase IIATPCNTN1alpha1beta1/alpha2beta1GTPL1CHL1:NP-1Clathrin-coated vesicleL1 homodimerunidentified protein tyrosine kinaseL1:clathrin-coated vesicleEPHB2pL1 (Y1229):L1CAML1:NUMB:CRMP-2:alpha-adaptinL1:AP-2 Clathrin complexL1ERM:PIP2L1NeurofascinKIF4 dimerATPF-actinSRCVAV2CHL1:Hsc70Neurofascin:NrCAM complexL1:Integrin complexL1:NeurocanNeurocanNrCAM:Axonin-1ADPNa+/K+ channel subunitsContactin1:CASPR complexphospho-ERK-2:MEK2L1:LamininATPpL1 (S1152):p90rsk:clathrin-dynamin complexL1L1:ALCAML1 trans-homodimer:AnkyrinRAC1-GTPEndophilinADPNFASC:pNFASCp-VAV2(Y172)L1:RanBPMADPLaminin-1 (EHS laminin)NrCAM:SAP membersFibroblast growth factor receptor 1c67


Description

The L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L1 (CHL1), NrCAM, and Neurofascin. These CAMs contain six Ig like domains, five or six fibronectin like repeats, a transmembrane region and a cytoplasmic domain. The L1CAM family has been implicated in processes integral to nervous system development, including neurite outgrowth, neurite fasciculation and inter neuronal adhesion.
L1CAM members are predominately expressed by neuronal, as well as some nonneuronal cells, during development. Except CHL1 all the other members of L1 family contain an alternatively spliced 12-nclueotide exon, encoding the amino acid residues RSLE in the neuronal splice forms but missing in the non-neuronal cells. The extracellular regions of L1CAM members are divergent and differ in their abilities to interact with extracellular, heterophilic ligands. The L1 ligands include other Ig-domain CAMs (such as NCAM, TAG-1/axonin and F11), proteoglycans type molecules (neurocan), beta1 integrins, and extra cellular matrix protein laminin, Neuropilin-1, FGF and EGF receptors. Some of these L1-interacting proteins also bind to other L1CAM members. For example TAG-1/axonin interact with L1 and NrCAM; L1, neurofascin and CHL1 binds to contactin family members. The cytoplasmic domains of L1CAM members are most highly conserved. Nevertheless, they have different cytoplasmic binding partners, and even those with similar binding partners may be involved in different signaling complexes and mechanisms. The most conserved feature of L1CAMs is their ability to interact with the actin cytoskeletal adapter protein ankyrin. The cytoplasmic ankyrin-binding domain, exhibits the highest degree of amino acid conservation throughout the L1 family.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114936view16:45, 25 January 2021ReactomeTeamReactome version 75
113381view11:45, 2 November 2020ReactomeTeamReactome version 74
112586view15:55, 9 October 2020ReactomeTeamReactome version 73
101501view11:37, 1 November 2018ReactomeTeamreactome version 66
101038view21:17, 31 October 2018ReactomeTeamreactome version 65
100569view19:51, 31 October 2018ReactomeTeamreactome version 64
100118view16:36, 31 October 2018ReactomeTeamreactome version 63
99668view15:06, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93887view13:43, 16 August 2017ReactomeTeamreactome version 61
93457view11:24, 9 August 2017ReactomeTeamreactome version 61
86550view09:20, 11 July 2016ReactomeTeamreactome version 56
83082view09:54, 18 November 2015ReactomeTeamVersion54
81408view12:56, 21 August 2015ReactomeTeamVersion53
76876view08:15, 17 July 2014ReactomeTeamFixed remaining interactions
76581view11:56, 16 July 2014ReactomeTeamFixed remaining interactions
75914view09:56, 11 June 2014ReactomeTeamRe-fixing comment source
75614view10:47, 10 June 2014ReactomeTeamReactome 48 Update
74969view13:49, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74613view08:39, 30 April 2014ReactomeTeamReactome46
44884view10:11, 6 October 2011MartijnVanIerselOntology Term : 'cell adhesion signaling pathway' added !
42061view21:53, 4 March 2011MaintBotAutomatic update
39869view05:53, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
ALCAM ProteinQ13740 (UniProt)
AP2 clathrin:L1:KIF4:

microtubule

ComplexREACT_23331 (Reactome)
ATP Metabolite15422 (ChEBI)
Activated ERK2 ProteinP28482 (UniProt)
Ankyrin-G ProteinP16157 (UniProt)
Ankyrins ProteinREACT_22717 (Reactome)
Axonin-1 ProteinQ02246 (UniProt)
CHL1 ProteinO00533 (UniProt)
CHL1:

alpha1beta1/alpha2b eta1 integrins

ComplexREACT_22459 (Reactome)
CHL1:Ankyrin-G ComplexREACT_23311 (Reactome)
CHL1:CNTN6 ComplexREACT_23145 (Reactome)
CHL1:Hsc70 ComplexREACT_22887 (Reactome)
CHL1:NP-1 ComplexREACT_22777 (Reactome)
CNTN1 ProteinQ12860 (UniProt)
CRMP-2:NUMB:alpha

adaptin

ComplexREACT_22454 (Reactome)
Casein kinase II ComplexREACT_23098 (Reactome)
Clathrin-coated

vesicle

ComplexREACT_13103 (Reactome)
Contactin-6 ProteinQ9UQ52 (UniProt)
Contactin1:CASPR

complex

ComplexREACT_23146 (Reactome)
Doublecortin ProteinO43602 (UniProt)
Dynamin-1/2/3 ProteinREACT_22651 (Reactome)
EGFR ProteinP00533 (UniProt)
EPHB2 ProteinP29323 (UniProt)
ERM:PIP2 ComplexREACT_22835 (Reactome)
Endophilin ProteinQ99962 (UniProt)
F-actin UnknownREACT_20433 (Reactome)
Fibroblast growth

factor receptor 1c

ProteinP11362-1 (UniProt)
GDP Metabolite17552 (ChEBI)
GTP Metabolite15996 (ChEBI)
Heat Stable Antigen

(HSA)

ProteinP25063 (UniProt)
Hsc70 ProteinP31948 (UniProt)
Integrins ComplexREACT_23070 (Reactome)
KIF4 dimer ComplexREACT_23088 (Reactome)
L1 ProteinP32004 (UniProt)
L1 dimer:Ankyrin:

Spectrin:F-actin

ComplexREACT_22451 (Reactome)
L1 homodimer ComplexREACT_22876 (Reactome)
L1 trans-

homodimer:Ankyrin

ComplexREACT_22843 (Reactome)
L1 trans-homodimer ComplexREACT_22570 (Reactome)
L1-EGFR trans-

heterodimer

ComplexREACT_22956 (Reactome)
L1:ALCAM ComplexREACT_23036 (Reactome)
L1:AP-2 Clathrin

complex

ComplexREACT_22867 (Reactome)
L1:AP-2 Clathrin

complex

ComplexREACT_22916 (Reactome)
L1:Axonin-1 ComplexREACT_23324 (Reactome)
L1:CNTN1 ComplexREACT_23027 (Reactome)
L1:FGFR1 ComplexREACT_22912 (Reactome)
L1:HNK-1 ComplexREACT_23380 (Reactome)
L1:HSA ComplexREACT_22674 (Reactome)
L1:Integrin complex ComplexREACT_22722 (Reactome)
L1:Laminin ComplexREACT_23226 (Reactome)
L1:NCAM1 complex ComplexREACT_23047 (Reactome)
L1:NP-1 ComplexREACT_23153 (Reactome)
L1:NUMB:CRMP-2:

alpha-adaptin

ComplexREACT_22785 (Reactome)
L1:Neurocan ComplexREACT_23328 (Reactome)
L1:RanBPM ComplexREACT_23100 (Reactome)
L1:clathrin-coated

vesicle

ComplexREACT_22698 (Reactome)
Laminin-1 (EHS

laminin)

ComplexREACT_14571 (Reactome)
MEK1:ERK-1 ComplexREACT_5539 (Reactome)
MEK2:ERK-2 ComplexREACT_5435 (Reactome)
NCAM1 ProteinP13591 (UniProt)
NFASC:pNFASC ComplexREACT_22522 (Reactome)
Na+/K+ channel

subunits

ComplexREACT_23061 (Reactome)
Neurocan ProteinO14594 (UniProt)
Neurofascin ProteinO94856 (UniProt)
Neurofascin:

Syntenin-1 complex

ComplexREACT_23202 (Reactome)
Neurofascin:Ankyrin-

G complex

ComplexREACT_22462 (Reactome)
Neurofascin:CNTN1:

CASPR complex

ComplexREACT_22948 (Reactome)
Neurofascin:NrCAM

complex

ComplexREACT_22606 (Reactome)
Neurofascin:NrCAM:

Ankyrin:spectrin based actin

ComplexREACT_23030 (Reactome)
Neurofascin:NrCAM:

Ankyrin:spectrin based actin:Na+/K+ channel

ComplexREACT_22749 (Reactome)
Neuropilin-1 ProteinO14786-1 (UniProt)
Neuropilin-2 (NP2) ProteinO60462 (UniProt)
NrCAM ProteinQ92823 (UniProt)
NrCAM:Ankyrin-G ComplexREACT_23219 (Reactome)
NrCAM:Axonin-1 ComplexREACT_23383 (Reactome)
NrCAM:NP-2 ComplexREACT_22473 (Reactome)
NrCAM:SAP

members

ComplexREACT_23321 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PAK1 ProteinQ13153 (UniProt)
PAK1 dimer

(inactive/autoinhibited )

ComplexREACT_23136 (Reactome)
RAC1-GDP ComplexREACT_22018 (Reactome)
RAC1-GTP ComplexREACT_21594 (Reactome)
RanBPM ProteinQ96S59 (UniProt)
SRC ProteinP12931-1 (UniProt)
Shootin-1 ProteinA0MZ66 (UniProt)
Syntenin-1 ProteinO00560 (UniProt)
Trans neurofascin

dimer:ankyrin-G

ComplexREACT_22613 (Reactome)
Tyr phos L1:EPHB2 ComplexREACT_23011 (Reactome)
VAV2 ProteinP52735 (UniProt)
alpha1beta1/alpha2b

eta1

ComplexREACT_22630 (Reactome)
microtubule UnknownREACT_10446 (Reactome)
p-VAV2(Y172) ProteinP52735 (UniProt)
p90rsk ProteinREACT_23173 (Reactome)
pL1 (S1152):p90rsk:

clathrin-dynamin complex

ComplexREACT_23209 (Reactome)
pL1 (S1204, 1248):

ERK2:clathrin- dynamin complex

ComplexREACT_23286 (Reactome)
pL1 (Y1176) ProteinP32004 (UniProt)
pL1 (Y1229):L1CAM ComplexREACT_22871 (Reactome)
pL1:CK-II ComplexREACT_22634 (Reactome)
pL1:ERM:F-actin ComplexREACT_22519 (Reactome)
pL1:Ezrin ComplexREACT_22884 (Reactome)
pL1:Shootin-1:F-

actin

ComplexREACT_22531 (Reactome)
pNFASC:Doublecortin ComplexREACT_23013 (Reactome)
pPAK1:Rac1-GTP ComplexREACT_23376 (Reactome)
phospho-ERK-1:

MEK1

ComplexREACT_2796 (Reactome)
phospho-ERK-2:

MEK2

ComplexREACT_3199 (Reactome)
spectrin based actin ComplexREACT_22921 (Reactome)
synapse-associated

proteins (SAP)

ProteinREACT_23280 (Reactome)
unidentified protein

tyrosine kinase

UnknownREACT_22532 (Reactome)
unknown protein UnknownREACT_22919 (Reactome)

Annotated Interactions

No annotated interactions

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