Angiogenesis overview (Homo sapiens)

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Stem CellDok-RCa2+TKTie2PakGFP85-PI3KP110transcription of angiogenesis-related genesROSeloCMT1-MMPMT-MMPProteosomeIntegrinsIQGAP1MigrationSTAT5CRKMEKMAP2K6Shp2Ras AKT1Robo1ANGPT1FRS2CDC42MAPK8Ca2+ - releaseFAKProliferationFAKSHBPHDMAP2K3SEKVEGFADia1ATF2FGF1IP2MAP3K7APCPIP3ERK 1/2 MAPKPIP2NRP1RAF1PDKsOHRASCDC42SurvivalMAP2K1NADPH oxidase 2Filipodia andlamellopodiaMAPK11RasAKTSurvivalGRB2FGFR1PLC-gammaSEMA3AThrombinPI3KElk1NOX4hypoxiaTIMP2MMPsDAG1DAG1Grb14SrcFilopodia andLamellopodiaGrb2IP3BmxPXNBADRobo4VHLSHC1Breakdown of extracellulartissue like collagenNOurokinase-plasminogen activatorMMP2SOS1PIP2CrkPKCMAPK1PLDSTAT3MMP12ROBO4Slit2TIMP4RAC1PLC-gammaPLXND1NOS3MMP9RAF1WASPPTPN11PermeabilitySEMA4APRKCANckRas GAPROBO1HIF2-alphaKDRMigrationp38 MAPKPla2TorSLIT2MigrationAngiogenesisHIF2-alphaHIF2-alphaOHpUbeloBGRB2SOS1Grb7Slit2Stem CellStem Cell


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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
126081view09:00, 1 April 2023EgonwRemoved unclear "GF" comment
126080view08:50, 1 April 2023EgonwAdded a few datanode types (guessed a few, because no IDs were given)
110975view14:21, 25 June 2020L DupuisConnected lines
106214view12:11, 16 August 2019MaintBotHMDB identifier normalization
85555view08:32, 29 May 2016EgonwReplaced a mim-conversion with Arrow.
71385view18:41, 17 October 2013MaintBotAutomated update of data sources
71268view21:58, 16 October 2013MaintBotAutomated update of data sources
69001view17:45, 8 July 2013MaintBotUpdated to 2013 gpml schema
59192view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
58505view19:00, 14 February 2013MaintBotModified title
44954view12:37, 6 October 2011MartijnVanIerselOntology Term : 'growth factor signaling pathway' added !
44820view13:30, 5 October 2011SusanModified description
44464view18:42, 14 September 2011MaintBotModified categories
44462view14:33, 14 September 2011Helixangiogenesis overview
44393view10:35, 8 September 2011Helixangiogenesis overviuew
44392view10:26, 8 September 2011HelixPeriodical save, work in progress
44389view10:15, 8 September 2011HelixPeriodical save, work in progress
43912view12:37, 16 August 2011Helixangiogensisi overview
43911view12:29, 16 August 2011HelixPeriodical save, work in progress
43909view12:19, 16 August 2011HelixPeriodical save, work in progress
43908view11:54, 16 August 2011HelixPeriodical save, work in progress
43907view11:43, 16 August 2011HelixPeriodical save, work in progress
43906view11:31, 16 August 2011Helixangiogenesis overview
43905view11:11, 16 August 2011HelixPeriodical save, work in progress
43902view11:48, 15 August 2011Helixangiogenesis overview
43901view11:46, 15 August 2011HelixPeriodical save, work in progress
43900view11:36, 15 August 2011HelixPeriodical save, work in progress
43899view11:26, 15 August 2011HelixPeriodical save, work in progress
43898view11:15, 15 August 2011HelixPeriodical save, work in progress
43896view11:04, 15 August 2011Helixangiogenesis overview
43605view09:00, 7 July 2011Helixangiopgenesis overview
43604view08:57, 7 July 2011HelixPeriodical save, work in progress
43603view08:46, 7 July 2011HelixPeriodical save, work in progress
43602view08:36, 7 July 2011HelixPeriodical save, work in progress
43596view09:28, 6 July 2011Helixangiogenesis overview
43146view13:05, 3 June 2011Helixangiogenesis overview
43145view12:58, 3 June 2011HelixPeriodical save, work in progress
43144view12:48, 3 June 2011HelixPeriodical save, work in progress
43143view12:37, 3 June 2011HelixPeriodical save, work in progress
43142view12:27, 3 June 2011HelixPeriodical save, work in progress
43141view12:17, 3 June 2011HelixPeriodical save, work in progress
43140view11:38, 3 June 2011HelixPeriodical save, work in progress
43139view11:28, 3 June 2011HelixPeriodical save, work in progress
43138view11:17, 3 June 2011HelixPeriodical save, work in progress
43137view11:07, 3 June 2011HelixPeriodical save, work in progress
43136view10:43, 3 June 2011HelixPeriodical save, work in progress
43135view10:40, 3 June 2011Helixangiogenesis overview
43134view10:33, 3 June 2011HelixPeriodical save, work in progress
43133view10:23, 3 June 2011HelixPeriodical save, work in progress
43132view10:13, 3 June 2011HelixPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTProtein
AKT1GeneProductENSG00000142208 (Ensembl Human)
ANGPT1GeneProductENSG00000154188 (Ensembl Human)
APCProtein
ATF2Protein
AngiogenesisPathway
BADGeneProductENSG00000002330 (Ensembl Human)
BmxProtein
Breakdown of extracellular tissue like collagenPathway
CDC42GeneProductENSG00000070831 (Ensembl Human)
CRKGeneProductENSG00000167193 (Ensembl Human)
Ca2+ - releasePathway
CrkProtein
DAG1GeneProductENSG00000173402 (Ensembl Human)
Dia1ProteinNP_031884.1 (RefSeq)
ERK 1/2 MAPKProtein
Elk1Protein
FAKProtein
FAKProteinQ14289 (Uniprot/TrEMBL)
FGF1GeneProductENSG00000113578 (Ensembl Human)
FGFR1GeneProductENSG00000077782 (Ensembl Human)
FRS2GeneProductENSG00000166225 (Ensembl Human)
Filipodia and lamellopodia
Filopodia and Lamellopodia
GRB2GeneProductENSG00000177885 (Ensembl Human)
Grb14Protein
Grb2Protein
Grb7Protein
HIF2-alphaProtein
IP2Protein
IP3
IQGAP1GeneProductENSG00000140575 (Ensembl Human)
KDRGeneProductENSG00000128052 (Ensembl Human)
MAP2K1GeneProductENSG00000169032 (Ensembl Human)
MAP2K3GeneProductENSG00000034152 (Ensembl Human)
MAP2K6GeneProductENSG00000108984 (Ensembl Human)
MAP3K7GeneProductENSG00000135341 (Ensembl Human)
MAPK11GeneProductENSG00000185386 (Ensembl Human) p38 MAPK
MAPK1GeneProductENSG00000100030 (Ensembl Human)
MAPK8GeneProductENSG00000107643 (Ensembl Human)
MEKProtein
MMP12Protein
MMP2Protein
MMP9Protein
MMPsGeneProductENSG00000087245 (Ensembl Human)
Migration
NADPH oxidase 2Protein
NO
NOS3GeneProductENSG00000164867 (Ensembl Human)
NOX4GeneProductENSG00000086991 (Ensembl Human)
NRP1GeneProductENSG00000099250 (Ensembl Human)
NckProtein
OH
PDKsProtein
PHDProtein
PI3KProtein
PIP2Protein
PIP2MetaboliteHMDB10032 (HMDB)
PIP3Protein
PKC
PLC-gammaGeneProduct5335 (Entrez Gene)
PLC-gammaGeneProductENSG00000124181 (Ensembl Human)
PLDProtein
PLXND1GeneProductENSG00000004399 (Ensembl Human)
PRKCAGeneProductENSG00000154229 (Ensembl Human)
PTPN11GeneProductENSG00000179295 (Ensembl Human)
PXNGeneProductENSG00000089159 (Ensembl Human)
PermeabilityPathway
Pla2Protein
ProliferationPathway
RAC1GeneProductENSG00000136238 (Ensembl Human)
RAF1GeneProductENSG00000132155 (Ensembl Human)
RASGeneProductENSG00000133703 (Ensembl Human)
ROBO1GeneProductENSG00000169855 (Ensembl Human)
ROBO4GeneProductENSG00000154133 (Ensembl Human)
RasProtein
Ras ProteinENSG00000133703 (Ensembl Human)
Ras GAPProtein
Robo1Protein
Robo4Protein
SEKProtein
SEMA3AGeneProductENSG00000075213 (Ensembl Human)
SEMA4AGeneProductENSG00000196189 (Ensembl Human)
SHBGeneProductENSG00000107338 (Ensembl Human)
SHC1GeneProductENSG00000160691 (Ensembl Human)
SLIT2GeneProductENSG00000145147 (Ensembl Human)
SOS1GeneProductENSG00000115904 (Ensembl Human)
STAT3Protein
STAT5Protein
Shp2Protein
Slit2
SrcProtein
Survival
TIMP2Protein
TIMP4Protein
ThrombinProtein
TorProtein
VEGFAGeneProductENSG00000112715 (Ensembl Human)
VHLGeneProductENSG00000134086 (Ensembl Human)
WASPProteinP42768 (Uniprot/TrEMBL)
hypoxia
p38 MAPKProtein
pUb
urokinase-plasminogen activatorProtein

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1993"
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