Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)

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1-12126-12851-5458-6256, 5713, 85106, 1079349, 504994, 95130132-134135, 136135, 13692129132-134111, 11265-6911080-83132-13439-4378, 79124, 12563, 6487117-11944-4697, 98132-13423, 2432-38106-10984-861688106, 107, 10924-31104, 10547, 48123102, 1039970, 711001769, 72-7489, 9013, 1011475-77114-1161511318-2290131121, 1221209649, 5591lysosomal lumenGolgi lumenlate endosome lumenearly endosome lumencytosolsynaptic vesicleligands of SLC7A2, isoform AL-Glutamatesodium ionSLC7A10:SLC3A2 heterodimersodium ionChlorideligands of SLC7A1 and SLC7A2 isoform Bligands of SLC7A10L-serineSodium/potassium/calcium exchanger 6sodium ionH+ligands of SLC6A19SLC6A15SLC43A2Orthophosphatesodium ionsodium ionSLC7A2, isoform Asodium ionsodium ionsodium ionChlorideligands of SLC7A1 and SLC7A2 isoform Bsodium ionL-ProlineSLC7A8:SLC3A2 heterodimersodium ionligands of SLC38A3sodium ionligands of SLC6A12 (BGT-1)ligands of SLC38A4SLC7A2, isoform BChlorideExcitatory amino acid transportersH+ligands of SLC16A10L-serineL-LeucineInhibitory amino acidsType III Na+/Pi cotransportersinorganic sulfateCl-/HCO3- exchanger proteinsH+L-Threoninesodium ionsodium ionsodium ionligands of SLC7A2, isoform AChloridesodium ionH+ligands of SLC6A6ligands of SLC7A5H+Sialinsodium ionSLC38A4alanine, serine, threonine, or cysteineligands of SLC6A19Acids transported by SMCT1SLC26 chloride transporterssodium ionChloridesodium ionH+HCO3-SLC1A4L-Alaninesodium ionligands of SLC36A1ChlorideDi-peptides/tri-peptidesNa+/Ca2+ exchanger proteinsH+SLC36A2SLC7A1sodium ionVGLUTsligands of SLC16A10ligands of SLC36A1SLC7A5:SLC3A2 heterodimerChlorideNa+/HCO3- symporter proteinsOrthophosphateligands of SLC38A3sodium ionPHT cotransportersCl-/HCO3- exchanger proteins (SLC26)H+SLC7A9:SLC3A1 heterodimerChlorideHCO3-SLC16A10sodium ionSLC1A4L-GlutamineL-Glutamatealanine, serine, threonine, or cysteineGlycineHistidine/di-peptidesligands of SLC43A1 and SLC43A2alanine, serine, threonine, or cysteineAcids transported by SMCT1H+H+sodium ionSLC38A3Calciumsodium ionL-AlaninePotassiumsodium ionDi-peptides/tri-peptidesNa+/K+/Ca2+ exchanger proteinsligands of SLC38A5SLC6A19ligands of SLC38A1sodium ionHCO3-NISligands of SLC38A5ligands of SLC6A15KCC cotransportersL-ArgininePotassiumH+PotassiumNKCC cotransportersL-Threoninearginine, cystine, lysineSLC7A7:SLC3A2 heterodimersodium ionSodium/hydrogen exchanger 9Electrogenic Na+/Pi cotransporterssodium ionH+H+H+ligands of SLC43A1 and SLC43A2H+Orthophosphateligands of SLC38A2L-cysteineSodium ionNa+/H+ exchanger proteins 7/8Orthophosphateglycinesodium ionHigh-affinity glutamate transporter ligandsH+L-AlanineSodium ionsodium ionligands of SLC6A15ChlorideChloridesodium ionsodium ionOrthophosphatealanine, serine, threonine, or cysteinePotassiumligands of SLC38A2L-cysteinearginine, cystine, lysineL-cysteinesialic acidNa+-driven Cl-/HCO3- exchanger proteinsChloridesodium ionsodium ionsodium ionH+H+HCO3-SLC6A20sodium ionalanine, serine, threonine, or cysteineSulfate transporterssodium ionsodium ionSLC7A11:SLC3A2 heterodimersodium ionL-cysteineH+sodium ionligands of SLC7A5sodium ionPotassiumsodium ionSLC6A6sodium ionsodium ionH+sodium ionsodium ionSLC38A5Li+sodium ionChlorideligands of SLC36A2sodium ionH+sodium ionPotassiumChloridesodium ionsodium ionligands of SLC36A2Histidine/di-peptidesligands of SLC6A6Potassiumsodium ionsodium ionHigh-affinity glutamate transporter ligandsChloridePotassiumIodidealanine, serine, threonine, or cysteineSLC6A12L-Alanineligands of SLC7A8H+Sodium/hydrogen exchanger 6SLC7A6:SLC3A2 heterodimerSLC6A14Sodium-dependent phosphate transport protein 1sodium ionligands of SLC7A3ChlorideL-ProlineSLC1A5CalciumSolute carrier family 12 member 3Chlorideligands of SLC6A14SMCT1sodium ionNa+/H+ exchanger proteinsligands of SLC6A14L-Leucinesodium ionSodium-dependent phosphate transport protein 2CSLC7A3SLC6A18sodium ionligands of SLC7A8L-GlutamateH+OrthophosphateSLC43A1H+sodium ionChloridesodium ionSLC1A4L-Glutamineligands of SLC38A4sodium ionVesicular inhibitory amino acid transporterL-ArginineH+Li+sodium ionligands of SLC6A12 (BGT-1)ligands of SLC38A1sodium ionalanine, serine, threonine, or cysteineH+H+ChlorideH+sodium ionSystem N amino acid transporter 1SLC36A1sodium ioninorganic sulfateligands of SLC7A10sialic acidligands of SLC7A3sodium ionH+L-GlutamateH+ChlorideChlorideIodideSLC1A4alanine, serine, threonine, or cysteinesodium ionH+Inhibitory amino acidsPEPT cotransportersSLC38A21615131413


Description

Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl–-dependent transport of basic anions [e.g. HCO3–, (CO3)2–] in various tissues and cell types (in addition to pH regulation, specific members of this family also contribute to vectorial trans-epithelial base transport in several organ systems including the kidney, pancreas, and eye) (Pushkin A and Kurtz I, 2006); SLC8 is a group of Na+/Ca2+ exchangers (SLC8A1 is involved in cardiac contractility) (Quednau BD et al, 2004); SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers (Altimimi HF and Schnetkamp PP, 2007); SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons (Orlowski J and Grinstein S, 2004); SLC12 functions as Na+, K+ and Cl– ion electroneutral symporters (Hebert SC et al, 2004); SLC26 is the trans-epithelial multifunctional anion (e.g. sulfate, oxalate, HCO3–, Cl–) exchanger family, important in cartilage development, production of thyroid hormone, sound amplification in the cochlea etc (Sindic A et al, 2007; Dorwart MR et al, 2008; Ashmore J, 2008). SLC34 is an important Type II Na+/(HPO4)2– symporter (Forster IC et al, 2006; Virkki LV et al, 2007); SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/(H2PO4)– symporter (Collins JF et al, 2004; Virkki LV et al, 2007). Eight SLC gene families are involved in the transport of amino acids and oligopeptides.

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  1. Dorwart MR, Shcheynikov N, Wang Y, Stippec S, Muallem S.; ''SLC26A9 is a Cl(-) channel regulated by the WNK kinases.''; PubMed Europe PMC Scholia
  2. Kamath SG, Furesz TC, Way BA, Smith CH.; ''Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1.''; PubMed Europe PMC Scholia
  3. Gillen CM, Brill S, Payne JA, Forbush B.; ''Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.''; PubMed Europe PMC Scholia
  4. Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G.; ''Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.''; PubMed Europe PMC Scholia
  5. Sloan JL, Mager S.; ''Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+).''; PubMed Europe PMC Scholia
  6. Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F.; ''Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.''; PubMed Europe PMC Scholia
  7. Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V.; ''Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.''; PubMed Europe PMC Scholia
  8. Shafqat S, Tamarappoo BK, Kilberg MS, Puranam RS, McNamara JO, Guadaño-Ferraz A, Fremeau RT.; ''Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.''; PubMed Europe PMC Scholia
  9. Seow HF, Bröer S, Bröer A, Bailey CG, Potter SJ, Cavanaugh JA, Rasko JE.; ''Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19.''; PubMed Europe PMC Scholia
  10. Takanaga H, Mackenzie B, Peng JB, Hediger MA.; ''Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain.''; PubMed Europe PMC Scholia
  11. Alper SL, Sharma AK.; ''The SLC26 gene family of anion transporters and channels.''; PubMed Europe PMC Scholia
  12. Pineda M, Fernández E, Torrents D, Estévez R, López C, Camps M, Lloberas J, Zorzano A, Palacín M.; ''Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids.''; PubMed Europe PMC Scholia
  13. Gopal E, Umapathy NS, Martin PM, Ananth S, Gnana-Prakasam JP, Becker H, Wagner CA, Ganapathy V, Prasad PD.; ''Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney.''; PubMed Europe PMC Scholia
  14. Payne JA, Xu JC, Haas M, Lytle CY, Ward D, Forbush B.; ''Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon.''; PubMed Europe PMC Scholia
  15. Matskevitch I, Wagner CA, Stegen C, Bröer S, Noll B, Risler T, Kwon HM, Handler JS, Waldegger S, Busch AE, Lang F.; ''Functional characterization of the Betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes.''; PubMed Europe PMC Scholia
  16. Nakamura N, Tanaka S, Teko Y, Mitsui K, Kanazawa H.; ''Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation.''; PubMed Europe PMC Scholia
  17. Burnham CE, Amlal H, Wang Z, Shull GE, Soleimani M.; ''Cloning and functional expression of a human kidney Na+:HCO3- cotransporter.''; PubMed Europe PMC Scholia
  18. Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G, Endou H.; ''Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities.''; PubMed Europe PMC Scholia
  19. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H.; ''Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.''; PubMed Europe PMC Scholia
  20. Pillai SM, Meredith D.; ''SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes.''; PubMed Europe PMC Scholia
  21. Simon DB, Karet FE, Hamdan JM, DiPietro A, Sanjad SA, Lifton RP.; ''Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2.''; PubMed Europe PMC Scholia
  22. Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP.; ''Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney.''; PubMed Europe PMC Scholia
  23. Agrimi G, Di Noia MA, Marobbio CM, Fiermonte G, Lasorsa FM, Palmieri F.; ''Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.''; PubMed Europe PMC Scholia
  24. Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM.; ''Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine.''; PubMed Europe PMC Scholia
  25. Molinari F, Raas-Rothschild A, Rio M, Fiermonte G, Encha-Razavi F, Palmieri L, Palmieri F, Ben-Neriah Z, Kadhom N, Vekemans M, Attie-Bitach T, Munnich A, Rustin P, Colleaux L.; ''Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy.''; PubMed Europe PMC Scholia
  26. Hatanaka T, Huang W, Ling R, Prasad PD, Sugawara M, Leibach FH, Ganapathy V.; ''Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A.''; PubMed Europe PMC Scholia
  27. Anikster Y, Shotelersuk V, Gahl WA.; ''CTNS mutations in patients with cystinosis.''; PubMed Europe PMC Scholia
  28. Waldegger S, Moschen I, Ramirez A, Smith RJ, Ayadi H, Lang F, Kubisch C.; ''Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family.''; PubMed Europe PMC Scholia
  29. Fernandes I, Béliveau R, Friedlander G, Silve C.; ''NaPO(4) cotransport type III (PiT1) expression in human embryonic kidney cells and regulation by PTH.''; PubMed Europe PMC Scholia
  30. Bröer A, Wagner CA, Lang F, Bröer S.; ''The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.''; PubMed Europe PMC Scholia
  31. Corut A, Senyigit A, Ugur SA, Altin S, Ozcelik U, Calisir H, Yildirim Z, Gocmen A, Tolun A.; ''Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis.''; PubMed Europe PMC Scholia
  32. Dossena S, Rodighiero S, Vezzoli V, Bazzini C, Sironi C, Meyer G, Fürst J, Ritter M, Garavaglia ML, Fugazzola L, Persani L, Zorowka P, Storelli C, Beck-Peccoz P, Bottá G, Paulmichl M.; ''Fast fluorometric method for measuring pendrin (SLC26A4) Cl-/I- transport activity.''; PubMed Europe PMC Scholia
  33. Brant SR, Yun CH, Donowitz M, Tse CM.; ''Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.''; PubMed Europe PMC Scholia
  34. Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH, Ganapathy V.; ''Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line.''; PubMed Europe PMC Scholia
  35. Vékony N, Wolf S, Boissel JP, Gnauert K, Closs EI.; ''Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues.''; PubMed Europe PMC Scholia
  36. Gasol E, Jiménez-Vidal M, Chillarón J, Zorzano A, Palacín M.; ''Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility.''; PubMed Europe PMC Scholia
  37. Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J.; ''Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.''; PubMed Europe PMC Scholia
  38. Boll M, Foltz M, Rubio-Aliaga I, Daniel H.; ''A cluster of proton/amino acid transporter genes in the human and mouse genomes.''; PubMed Europe PMC Scholia
  39. Takamori S, Malherbe P, Broger C, Jahn R.; ''Molecular cloning and functional characterization of human vesicular glutamate transporter 3.''; PubMed Europe PMC Scholia
  40. Vincourt JB, Jullien D, Amalric F, Girard JP.; ''Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules.''; PubMed Europe PMC Scholia
  41. Magagnin S, Werner A, Markovich D, Sorribas V, Stange G, Biber J, Murer H.; ''Expression cloning of human and rat renal cortex Na/Pi cotransport.''; PubMed Europe PMC Scholia
  42. Takamori S, Rhee JS, Rosenmund C, Jahn R.; ''Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2).''; PubMed Europe PMC Scholia
  43. van Zeijl M, Johann SV, Closs E, Cunningham J, Eddy R, Shows TB, O'Hara B.; ''A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family.''; PubMed Europe PMC Scholia
  44. Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, Tatsumi S, Miyamoto K.; ''Growth-related renal type II Na/Pi cotransporter.''; PubMed Europe PMC Scholia
  45. Elmonem MA, Veys KR, Soliman NA, van Dyck M, van den Heuvel LP, Levtchenko E.; ''Cystinosis: a review.''; PubMed Europe PMC Scholia
  46. Fu C, Bardhan S, Cetateanu ND, Wamil BD, Wang Y, Yan HP, Shi E, Carter C, Venkov C, Yakes FM, Page DL, Lloyd RS, Mernaugh RL, Hellerqvist CG.; ''Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis.''; PubMed Europe PMC Scholia
  47. Regeer RR, Lee A, Markovich D.; ''Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1).''; PubMed Europe PMC Scholia
  48. Takanaga H, Mackenzie B, Suzuki Y, Hediger MA.; ''Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino.''; PubMed Europe PMC Scholia
  49. Numata M, Orlowski J.; ''Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.''; PubMed Europe PMC Scholia
  50. Furesz TC, Heath-Monnig E, Kamath SG, Smith CH.; ''Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes.''; PubMed Europe PMC Scholia
  51. Song L, Mercado A, Vázquez N, Xie Q, Desai R, George AL, Gamba G, Mount DB.; ''Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.''; PubMed Europe PMC Scholia
  52. Botka CW, Wittig TW, Graul RC, Nielsen CU, Higaka K, Amidon GL, Sadée W.; ''Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics.''; PubMed Europe PMC Scholia
  53. Smanik PA, Liu Q, Furminger TL, Ryu K, Xing S, Mazzaferri EL, Jhiang SM.; ''Cloning of the human sodium lodide symporter.''; PubMed Europe PMC Scholia
  54. Fei YJ, Sugawara M, Nakanishi T, Huang W, Wang H, Prasad PD, Leibach FH, Ganapathy V.; ''Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter.''; PubMed Europe PMC Scholia
  55. Saito H, Motohashi H, Mukai M, Inui K.; ''Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1.''; PubMed Europe PMC Scholia
  56. Park SY, Kim JK, Kim IJ, Choi BK, Jung KY, Lee S, Park KJ, Chairoungdua A, Kanai Y, Endou H, Kim DK.; ''Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule.''; PubMed Europe PMC Scholia
  57. Babu E, Kanai Y, Chairoungdua A, Kim DK, Iribe Y, Tangtrongsup S, Jutabha P, Li Y, Ahmed N, Sakamoto S, Anzai N, Nagamori S, Endou H.; ''Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters.''; PubMed Europe PMC Scholia
  58. Bodoy S, Martín L, Zorzano A, Palacín M, Estévez R, Bertran J.; ''Identification of LAT4, a novel amino acid transporter with system L activity.''; PubMed Europe PMC Scholia
  59. Race JE, Makhlouf FN, Logue PJ, Wilson FH, Dunham PB, Holtzman EJ.; ''Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.''; PubMed Europe PMC Scholia
  60. Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SR, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Visser G, Eggermann T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A.; ''Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder.''; PubMed Europe PMC Scholia
  61. Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T.; ''Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.''; PubMed Europe PMC Scholia
  62. Chiaverini C, Sillard L, Flori E, Ito S, Briganti S, Wakamatsu K, Fontas E, Berard E, Cailliez M, Cochat P, Foulard M, Guest G, Niaudet P, Picardo M, Bernard FX, Antignac C, Ortonne JP, Ballotti R.; ''Cystinosin is a melanosomal protein that regulates melanin synthesis.''; PubMed Europe PMC Scholia
  63. Abuladze N, Lee I, Newman D, Hwang J, Boorer K, Pushkin A, Kurtz I.; ''Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter.''; PubMed Europe PMC Scholia
  64. Höglund P, Haila S, Socha J, Tomaszewski L, Saarialho-Kere U, Karjalainen-Lindsberg ML, Airola K, Holmberg C, de la Chapelle A, Kere J.; ''Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea.''; PubMed Europe PMC Scholia
  65. Quan H, Athirakul K, Wetsel WC, Torres GE, Stevens R, Chen YT, Coffman TM, Caron MG.; ''Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.''; PubMed Europe PMC Scholia
  66. Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H.; ''The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.''; PubMed Europe PMC Scholia
  67. Fiermonte G, Dolce V, Arrigoni R, Runswick MJ, Walker JE, Palmieri F.; ''Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.''; PubMed Europe PMC Scholia
  68. Mizoguchi K, Cha SH, Chairoungdua A, Kim DK, Shigeta Y, Matsuo H, Fukushima J, Awa Y, Akakura K, Goya T, Ito H, Endou H, Kanai Y.; ''Human cystinuria-related transporter: localization and functional characterization.''; PubMed Europe PMC Scholia
  69. O'Hara B, Johann SV, Klinger HP, Blair DG, Rubinson H, Dunn KJ, Sass P, Vitek SM, Robins T.; ''Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus.''; PubMed Europe PMC Scholia
  70. Hatanaka T, Huang W, Wang H, Sugawara M, Prasad PD, Leibach FH, Ganapathy V.; ''Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.''; PubMed Europe PMC Scholia
  71. Verheijen FW, Verbeek E, Aula N, Beerens CE, Havelaar AC, Joosse M, Peltonen L, Aula P, Galjaard H, van der Spek PJ, Mancini GM.; ''A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases.''; PubMed Europe PMC Scholia
  72. Malakooti J, Dahdal RY, Schmidt L, Layden TJ, Dudeja PK, Ramaswamy K.; ''Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2.''; PubMed Europe PMC Scholia
  73. Arriza JL, Kavanaugh MP, Fairman WA, Wu YN, Murdoch GH, North RA, Amara SG.; ''Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.''; PubMed Europe PMC Scholia
  74. Porcelli V, Fiermonte G, Longo A, Palmieri F.; ''The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids.''; PubMed Europe PMC Scholia
  75. Sardet C, Franchi A, Pouysségur J.; ''Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.''; PubMed Europe PMC Scholia
  76. Forster IC, Köhler K, Biber J, Murer H.; ''Forging the link between structure and function of electrogenic cotransporters: the renal type IIa Na+/Pi cotransporter as a case study.''; PubMed Europe PMC Scholia
  77. Anderson CM, Ganapathy V, Thwaites DT.; ''Human solute carrier SLC6A14 is the beta-alanine carrier.''; PubMed Europe PMC Scholia
  78. Crompton M, Palmieri F, Capano M, Quagliariello E.; ''The transport of sulphate and sulphite in rat liver mitochondria.''; PubMed Europe PMC Scholia
  79. Ginger RS, Askew SE, Ogborne RM, Wilson S, Ferdinando D, Dadd T, Smith AM, Kazi S, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Green MR.; ''SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.''; PubMed Europe PMC Scholia
  80. Yamaguchi S, Ishikawa T.; ''AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B.''; PubMed Europe PMC Scholia
  81. Baird NR, Orlowski J, Szabó EZ, Zaun HC, Schultheis PJ, Menon AG, Shull GE.; ''Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain.''; PubMed Europe PMC Scholia
  82. Forster IC, Loo DD, Eskandari S.; ''Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters.''; PubMed Europe PMC Scholia
  83. Kishita Y, Pajak A, Bolar NA, Marobbio CM, Maffezzini C, Miniero DV, Monné M, Kohda M, Stranneheim H, Murayama K, Naess K, Lesko N, Bruhn H, Mourier A, Wibom R, Nennesmo I, Jespers A, Govaert P, Ohtake A, Van Laer L, Loeys BL, Freyer C, Palmieri F, Wredenberg A, Okazaki Y, Wedell A.; ''Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26.''; PubMed Europe PMC Scholia
  84. Rasola A, Galietta LJ, Barone V, Romeo G, Bagnasco S.; ''Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney.''; PubMed Europe PMC Scholia
  85. Liu W, Liang R, Ramamoorthy S, Fei YJ, Ganapathy ME, Hediger MA, Ganapathy V, Leibach FH.; ''Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney.''; PubMed Europe PMC Scholia
  86. Höglund PJ, Adzic D, Scicluna SJ, Lindblom J, Fredriksson R.; ''The repertoire of solute carriers of family 6: identification of new human and rodent genes.''; PubMed Europe PMC Scholia
  87. Brett CL, Wei Y, Donowitz M, Rao R.; ''Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria.''; PubMed Europe PMC Scholia
  88. Prié D, Huart V, Bakouh N, Planelles G, Dellis O, Gérard B, Hulin P, Benqué-Blanchet F, Silve C, Grandchamp B, Friedlander G.; ''Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.''; PubMed Europe PMC Scholia
  89. Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH.; ''Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization.''; PubMed Europe PMC Scholia
  90. Chen Z, Fei YJ, Anderson CM, Wake KA, Miyauchi S, Huang W, Thwaites DT, Ganapathy V.; ''Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2.''; PubMed Europe PMC Scholia
  91. Fujiwara H, Tatsumi K, Miki K, Harada T, Miyai K, Takai S, Amino N.; ''Congenital hypothyroidism caused by a mutation in the Na+/I- symporter.''; PubMed Europe PMC Scholia
  92. Coady MJ, Chang MH, Charron FM, Plata C, Wallendorff B, Sah JF, Markowitz SD, Romero MF, Lapointe JY.; ''The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter.''; PubMed Europe PMC Scholia
  93. Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, Cha SH, Inatomi J, Shiokawa Y, Yamaguchi K, Saito I, Endou H, Kanai Y.; ''Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity.''; PubMed Europe PMC Scholia
  94. Town M, Jean G, Cherqui S, Attard M, Forestier L, Whitmore SA, Callen DF, Gribouval O, Broyer M, Bates GP, van't Hoff W, Antignac C.; ''A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis.''; PubMed Europe PMC Scholia
  95. Bergwitz C, Roslin NM, Tieder M, Loredo-Osti JC, Bastepe M, Abu-Zahra H, Frappier D, Burkett K, Carpenter TO, Anderson D, Garabedian M, Sermet I, Fujiwara TM, Morgan K, Tenenhouse HS, Juppner H.; ''SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis.''; PubMed Europe PMC Scholia
  96. Aula N, Salomäki P, Timonen R, Verheijen F, Mancini G, Månsson JE, Aula P, Peltonen L.; ''The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation.''; PubMed Europe PMC Scholia
  97. Hästbacka J, de la Chapelle A, Mahtani MM, Clines G, Reeve-Daly MP, Daly M, Hamilton BA, Kusumi K, Trivedi B, Weaver A.; ''The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping.''; PubMed Europe PMC Scholia
  98. Closs EI, Gräf P, Habermeier A, Cunningham JM, Förstermann U.; ''Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties.''; PubMed Europe PMC Scholia
  99. Bassi MT, Gasol E, Manzoni M, Pineda M, Riboni M, Martín R, Zorzano A, Borsani G, Palacín M.; ''Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-.''; PubMed Europe PMC Scholia
  100. Fiermonte G, Palmieri L, Todisco S, Agrimi G, Palmieri F, Walker JE.; ''Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.''; PubMed Europe PMC Scholia
  101. Nakanishi T, Sugawara M, Huang W, Martindale RG, Leibach FH, Ganapathy ME, Prasad PD, Ganapathy V.; ''Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N.''; PubMed Europe PMC Scholia
  102. Prasad PD, Wang H, Huang W, Kekuda R, Rajan DP, Leibach FH, Ganapathy V.; ''Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function.''; PubMed Europe PMC Scholia
  103. Kim KH, Shcheynikov N, Wang Y, Muallem S.; ''SLC26A7 is a Cl- channel regulated by intracellular pH.''; PubMed Europe PMC Scholia
  104. Howard HC, Mount DB, Rochefort D, Byun N, Dupré N, Lu J, Fan X, Song L, Rivière JB, Prévost C, Horst J, Simonati A, Lemcke B, Welch R, England R, Zhan FQ, Mercado A, Siesser WB, George AL, McDonald MP, Bouchard JP, Mathieu J, Delpire E, Rouleau GA.; ''The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum.''; PubMed Europe PMC Scholia
  105. Wang H, Huang W, Sugawara M, Devoe LD, Leibach FH, Prasad PD, Ganapathy V.; ''Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta.''; PubMed Europe PMC Scholia
  106. Mastroianni N, De Fusco M, Zollo M, Arrigo G, Zuffardi O, Bettinelli A, Ballabio A, Casari G.; ''Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3).''; PubMed Europe PMC Scholia
  107. Miyauchi S, Gopal E, Fei YJ, Ganapathy V.; ''Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids.''; PubMed Europe PMC Scholia
  108. Bröer A, Wagner C, Lang F, Bröer S.; ''Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance.''; PubMed Europe PMC Scholia
  109. Zerangue N, Kavanaugh MP.; ''ASCT-1 is a neutral amino acid exchanger with chloride channel activity.''; PubMed Europe PMC Scholia
  110. Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR, Paul SM.; ''Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter.''; PubMed Europe PMC Scholia
  111. Chong SS, Kristjansson K, Zoghbi HY, Hughes MR.; ''Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23.''; PubMed Europe PMC Scholia
  112. Simon DB, Nelson-Williams C, Bia MJ, Ellison D, Karet FE, Molina AM, Vaara I, Iwata F, Cushner HM, Koolen M, Gainza FJ, Gitleman HJ, Lifton RP.; ''Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter.''; PubMed Europe PMC Scholia
  113. Bröer S.; ''Amino acid transport across mammalian intestinal and renal epithelia.''; PubMed Europe PMC Scholia
  114. Schweinfest CW, Henderson KW, Suster S, Kondoh N, Papas TS.; ''Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114876view16:38, 25 January 2021ReactomeTeamReactome version 75
113322view11:39, 2 November 2020ReactomeTeamReactome version 74
112533view15:49, 9 October 2020ReactomeTeamReactome version 73
101446view11:31, 1 November 2018ReactomeTeamreactome version 66
100984view21:10, 31 October 2018ReactomeTeamreactome version 65
100520view19:44, 31 October 2018ReactomeTeamreactome version 64
100067view16:27, 31 October 2018ReactomeTeamreactome version 63
99618view15:00, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99226view12:44, 31 October 2018ReactomeTeamreactome version 62
93794view13:36, 16 August 2017ReactomeTeamreactome version 61
93330view11:20, 9 August 2017ReactomeTeamreactome version 61
86415view09:17, 11 July 2016ReactomeTeamreactome version 56
83267view10:36, 18 November 2015ReactomeTeamVersion54
81376view12:54, 21 August 2015ReactomeTeamVersion53
76845view08:07, 17 July 2014ReactomeTeamFixed remaining interactions
76549view11:53, 16 July 2014ReactomeTeamFixed remaining interactions
75882view09:53, 11 June 2014ReactomeTeamRe-fixing comment source
75582view10:41, 10 June 2014ReactomeTeamReactome 48 Update
74937view13:46, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74581view08:37, 30 April 2014ReactomeTeamReactome46
45061view20:00, 6 October 2011KhanspersOntology Term : 'transport pathway' added !
42151view22:00, 4 March 2011MaintBotAutomatic update
39962view05:58, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acids transported by

SMCT1

MetaboliteREACT_19944 (Reactome)
Acids transported by

SMCT1

MetaboliteREACT_20122 (Reactome)
Calcium Metabolite29108 (ChEBI)
Chloride Metabolite17996 (ChEBI)
Cl-/HCO3-

exchanger proteins

UnknownREACT_20076 (Reactome)
Cl-/HCO3-

exchanger proteins (SLC26)

UnknownREACT_20307 (Reactome)
Di-

peptides/tri- peptides

ComplexREACT_20441 (Reactome)
Di-

peptides/tri- peptides

ComplexREACT_20481 (Reactome)
Electrogenic Na+/Pi

cotransporters

UnknownREACT_20196 (Reactome)
Excitatory amino acid

transporters

UnknownREACT_19879 (Reactome)
Glycine Metabolite15428 (ChEBI)
H+ Metabolite15378 (ChEBI)
HCO3- Metabolite17544 (ChEBI)
High-affinity glutamate

transporter ligands

MetaboliteREACT_19595 (Reactome)
High-affinity glutamate

transporter ligands

MetaboliteREACT_20284 (Reactome)
Histidine/di-

peptides

ComplexREACT_20346 (Reactome)
Histidine/di-peptides MetaboliteREACT_20464 (Reactome)
Inhibitory amino acids MetaboliteREACT_19773 (Reactome)
Inhibitory amino acids MetaboliteREACT_19986 (Reactome)
Iodide Metabolite16382 (ChEBI)
KCC cotransporters UnknownREACT_19723 (Reactome)
L-Alanine Metabolite16977 (ChEBI)
L-Arginine Metabolite16467 (ChEBI)
L-Glutamate Metabolite16015 (ChEBI)
L-Glutamine Metabolite18050 (ChEBI)
L-Leucine Metabolite15603 (ChEBI)
L-Proline Metabolite17203 (ChEBI)
L-Threonine Metabolite16857 (ChEBI)
L-cysteine Metabolite17561 (ChEBI)
L-serine Metabolite17115 (ChEBI)
Li+ Metabolite49713 (ChEBI)
NIS ProteinQ92911 (UniProt)
NKCC cotransporters UnknownREACT_20085 (Reactome)
Na+-driven Cl-

/HCO3- exchanger proteins

UnknownREACT_19659 (Reactome)
Na+/Ca2+

exchanger proteins

UnknownREACT_20277 (Reactome)
Na+/H+

exchanger proteins

UnknownREACT_20090 (Reactome)
Na+/H+

exchanger proteins 7/8

UnknownREACT_20455 (Reactome)
Na+/HCO3-

symporter proteins

UnknownREACT_20393 (Reactome)
Na+/K+/Ca2+

exchanger proteins

UnknownREACT_20166 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PEPT cotransporters UnknownREACT_19865 (Reactome)
PHT cotransporters UnknownREACT_19869 (Reactome)
Potassium Metabolite29103 (ChEBI)
SLC16A10 ProteinQ8TF71 (UniProt)
SLC1A4 ProteinP43007 (UniProt)
SLC1A5 ProteinQ15758 (UniProt)
SLC26 chloride

transporters

UnknownREACT_19871 (Reactome)
SLC36A1 ProteinQ7Z2H8 (UniProt)
SLC36A2 ProteinQ495M3 (UniProt)
SLC38A2 ProteinQ96QD8 (UniProt)
SLC38A3 ProteinQ99624 (UniProt)
SLC38A4 ProteinQ969I6 (UniProt)
SLC38A5 ProteinQ8WUX1 (UniProt)
SLC43A1 ProteinO75387 (UniProt)
SLC43A2 ProteinQ8N370 (UniProt)
SLC6A12 ProteinP48065 (UniProt)
SLC6A14 ProteinQ9UN76 (UniProt)
SLC6A15 ProteinQ9H2J7 (UniProt)
SLC6A18 ProteinQ96N87 (UniProt)
SLC6A19 ProteinQ695T7 (UniProt)
SLC6A20 ProteinQ9NP91 (UniProt)
SLC6A6 ProteinP31641 (UniProt)
SLC7A1 ProteinP30825 (UniProt)
SLC7A10:SLC3A2

heterodimer

ComplexREACT_15256 (Reactome)
SLC7A11:SLC3A2

heterodimer

ComplexREACT_16127 (Reactome)
SLC7A2, isoform A ProteinP52569-2 (UniProt)
SLC7A2, isoform B ProteinP52569-1 (UniProt)
SLC7A3 ProteinQ8WY07 (UniProt)
SLC7A5:SLC3A2

heterodimer

ComplexREACT_14214 (Reactome)
SLC7A6:SLC3A2

heterodimer

ComplexREACT_17753 (Reactome)
SLC7A7:SLC3A2

heterodimer

ComplexREACT_17357 (Reactome)
SLC7A8:SLC3A2

heterodimer

ComplexREACT_14666 (Reactome)
SLC7A9:SLC3A1

heterodimer

ComplexREACT_17730 (Reactome)
SMCT1 ProteinQ8N695 (UniProt)
Sialin ProteinQ9NRA2 (UniProt)
Sodium ion Metabolite29101 (ChEBI)
Sodium-dependent

phosphate transport protein 1

ProteinQ14916 (UniProt)
Sodium-dependent

phosphate transport protein 2C

ProteinQ8N130 (UniProt)
Sodium/hydrogen

exchanger 6

ProteinQ92581 (UniProt)
Sodium/hydrogen

exchanger 9

ProteinQ8IVB4 (UniProt)
Sodium/potassium/cal

cium exchanger 6

ProteinQ6J4K2 (UniProt)
Solute carrier family

12 member 3

ProteinP55017 (UniProt)
Sulfate transporters UnknownREACT_19980 (Reactome)
System N amino acid

transporter 1

ProteinQ9H2H9 (UniProt)
Type III Na+/Pi

cotransporters

UnknownREACT_19685 (Reactome)
VGLUTs UnknownREACT_19634 (Reactome)
Vesicular inhibitory

amino acid transporter

ProteinQ9H598 (UniProt)
alanine, serine,

threonine, or cysteine

MetaboliteREACT_14477 (Reactome)
alanine, serine,

threonine, or cysteine

MetaboliteREACT_14614 (Reactome)
arginine, cystine,

lysine

MetaboliteREACT_17488 (Reactome)
arginine, cystine,

lysine

MetaboliteREACT_17929 (Reactome)
glycine Metabolite15428 (ChEBI)
inorganic sulfate Metabolite16189 (ChEBI)
ligands of SLC16A10 MetaboliteREACT_14064 (Reactome)
ligands of SLC16A10 MetaboliteREACT_14325 (Reactome)
ligands of SLC36A1 MetaboliteREACT_14867 (Reactome)
ligands of SLC36A1 MetaboliteREACT_15239 (Reactome)
ligands of SLC36A2 MetaboliteREACT_15066 (Reactome)
ligands of SLC36A2 MetaboliteREACT_15209 (Reactome)
ligands of SLC38A1 MetaboliteREACT_14092 (Reactome)
ligands of SLC38A1 MetaboliteREACT_14635 (Reactome)
ligands of SLC38A2 MetaboliteREACT_13984 (Reactome)
ligands of SLC38A2 MetaboliteREACT_14296 (Reactome)
ligands of SLC38A3 MetaboliteREACT_13991 (Reactome)
ligands of SLC38A3 MetaboliteREACT_14234 (Reactome)
ligands of SLC38A4 MetaboliteREACT_14058 (Reactome)
ligands of SLC38A4 MetaboliteREACT_14105 (Reactome)
ligands of SLC38A5 MetaboliteREACT_13843 (Reactome)
ligands of SLC38A5 MetaboliteREACT_14636 (Reactome)
ligands of SLC43A1

and SLC43A2

MetaboliteREACT_13952 (Reactome)
ligands of SLC43A1

and SLC43A2

MetaboliteREACT_14610 (Reactome)
ligands of SLC6A12

(BGT-1)

MetaboliteREACT_14225 (Reactome)
ligands of SLC6A12

(BGT-1)

MetaboliteREACT_14644 (Reactome)
ligands of SLC6A14 MetaboliteREACT_15161 (Reactome)
ligands of SLC6A14 MetaboliteREACT_15206 (Reactome)
ligands of SLC6A15 MetaboliteREACT_13883 (Reactome)
ligands of SLC6A15 MetaboliteREACT_14097 (Reactome)
ligands of SLC6A19 MetaboliteREACT_15160 (Reactome)
ligands of SLC6A19 MetaboliteREACT_15227 (Reactome)
ligands of SLC6A6 MetaboliteREACT_14486 (Reactome)
ligands of SLC6A6 MetaboliteREACT_14671 (Reactome)
ligands of SLC7A1 and

SLC7A2 isoform B

MetaboliteREACT_15195 (Reactome)
ligands of SLC7A1 and

SLC7A2 isoform B

MetaboliteREACT_17674 (Reactome)
ligands of SLC7A10 MetaboliteREACT_15039 (Reactome)
ligands of SLC7A10 MetaboliteREACT_15265 (Reactome)
ligands of SLC7A2,

isoform A

MetaboliteREACT_15006 (Reactome)
ligands of SLC7A2,

isoform A

MetaboliteREACT_15174 (Reactome)
ligands of SLC7A3 MetaboliteREACT_15019 (Reactome)
ligands of SLC7A3 MetaboliteREACT_15247 (Reactome)
ligands of SLC7A5 MetaboliteREACT_14158 (Reactome)
ligands of SLC7A5 MetaboliteREACT_14292 (Reactome)
ligands of SLC7A8 MetaboliteREACT_14072 (Reactome)
ligands of SLC7A8 MetaboliteREACT_14264 (Reactome)
sialic acid Metabolite21622 (ChEBI)
sodium ion Metabolite29101 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1936"
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