Ovarian infertility (Homo sapiens)
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Description
Ovarian âbottleneckâ genes associated with infertility.
A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under âmutation typeâ) causing infertility (âinfertile - ovarian defectâ, under âfemale fertility statusâ) in mice (under âspeciesâ), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies.
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