Nifedipine activity (Homo sapiens)

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79Antithrombotic77778381Ca uptakephosphorylationin vivoAntiprolerative77NONitrosonifedipinephosphorylationSerum induced DNA synthesis83AntioxidativeLactam derivateDelay G0/G1 --> S-phase7981Rapid degration by daylight77KDR/FIK1 receptor/channel81, 88NifedipinephosphorylationAntiartherosclerosisNa balance77METABOLISM liver and small intestineFe uptake8679, 82, 8481ROS88797986Angiogenesis86Vasodilatation79Zn uptake8879CholesterolCa-channel798181cell growth inhibitionBradykinin II receptor83PCNAPKCCYP3A4NADPH oxidaseMAP2K1SODVEGFCholesterol esteraseMAPK1CYP2C11PTK2BCholesterol hydrolase1


Description

Nifedipine (brand names Adalat, Nifediac, Cordipin, Nifedical, and Procardia) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers. Source: Wikipedia (wikipedia:Nifedipine)

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Bibliography

  1. Hirata A, Igarashi M, Yamaguchi H, Suwabe A, Daimon M, Kato T, Tominaga M; ''Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2.''; Br J Pharmacol, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126432view10:11, 28 April 2023EgonwLicense is CCZero
118184view10:51, 25 May 2021EweitzModified title
106191view12:08, 16 August 2019MaintBotHMDB identifier normalization
88585view19:25, 11 August 2016Mkutmonfix unconnected lines
75227view19:24, 12 May 2014Khansperslayout, xrefs, connections
74419view12:42, 18 April 2014EgonwConverted two labels into metabolite DataNodes with an identifier.
71991view11:18, 24 October 2013MkutmonChanged Unknown -> GeneProduct for all annotated data nodes
68905view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67508view11:18, 26 June 2013DdiglesOntology Term : 'nifedipine drug pathway' added !
45358view20:43, 7 October 2011KhanspersModified description
45357view20:42, 7 October 2011KhanspersModified description
45356view20:41, 7 October 2011KhanspersOntology Term : 'heart disease' added !
45355view20:40, 7 October 2011KhanspersOntology Term : 'hypertension' added !
41054view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39776view21:35, 17 January 2011AlexanderPicomore complete title
38868view18:23, 24 September 2010KhanspersChanged line types
34583view22:23, 21 December 2009KhanspersModified categories
34447view18:20, 10 December 2009MaintBotAutomatic update of empty xrefs
26597view19:11, 10 December 2008AlexanderPicoupdate
26595view19:10, 10 December 2008AlexanderPicoadded connectors, database refs and literature ref
26593view19:05, 10 December 2008AlexanderPicoPeriodical save, work in progress
21223view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:test1234]] moved to [[Pathway:WP259]]: Moved to stable identifier
20471view10:39, 7 November 2008RobatwikiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CYP2C11
CYP3A41576 (Entrez Gene)
Cholesterol esterase
Cholesterol hydrolase
MAP2K15604 (Entrez Gene)
MAPK15594 (Entrez Gene)
NADPH oxidase
PCNA5111 (Entrez Gene)
PKC50818 (Entrez Gene)
PTK2B2185 (Entrez Gene)
SOD
VEGF

Annotated Interactions

No annotated interactions

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