Heart Development (Homo sapiens)

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Revision as of 18:03, 10 November 2011 by Nsalomonis (Talk | contribs)
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8511244243773First Heart FieldASRVDay 28Second Heart FieldCardiac Neural CrestLVRACardiac Reprogramming FactorsCTFibroblastLAGATA4MEF2CNKX2-5BMP2NKX2-5MEF2CVEGFBGATA4TBX5FGF8MIR145GATA4FOXH1TBX20BMP2MIR1-1BHLHE40PTPN11VEGFAISL1BMP4FOXC2ERBB3MAPK1SRFTBX2TBX20FOXA2MIR143BMPR1AFOXC1HEY2TBX5NFATC4SRFMEF2CIRX4NOTCH1TBX2TBX5NFATC2CTNNB1GATA4VEGFCSMAD1SMYD1SHHBMPR2FGF10HAND2NOTCH1HAND1TBX1SMAD4NKX2-5NFATC1BMP10HEY1NKX2-5TBX5NKX2-5NFATC3GATA6PITX2Sternal GenesCombination of First and SecondHeart Fields (Heart Valves)


Description

This pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impact the regional specificity of the human heart. Activating signals are indicated by arrows while inhibitory signals are indicated by T-bars. Special thanks to Kim Cordes for her assistance in revising this pathway, based on recent heart development research.

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Bibliography


History

CompareRevisionActionTimeUserComment
45786view18:06, 10 November 2011NsalomonisDeleted pathway: Species should be Mm
45785view18:03, 10 November 2011NsalomonisModified title
45784view18:01, 10 November 2011NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BHLHE40GeneProduct8553 (Entrez Gene) In other species, this is BHLHB2
BMP10GeneProduct27302 (Entrez Gene)
BMP2GeneProduct650 (Entrez Gene)
BMP4GeneProduct652 (Entrez Gene)
BMPR1AGeneProduct657 (Entrez Gene)
BMPR2GeneProduct659 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
ERBB3GeneProduct2065 (Entrez Gene)
FGF10GeneProduct2255 (Entrez Gene)
FGF8GeneProduct2253 (Entrez Gene)
FOXA2GeneProduct3170 (Entrez Gene)
FOXC1GeneProduct2296 (Entrez Gene)
FOXC2GeneProduct2303 (Entrez Gene)
FOXH1GeneProduct8928 (Entrez Gene)
GATA4GeneProduct2626 (Entrez Gene)
GATA6GeneProduct2627 (Entrez Gene)
HAND1GeneProduct9421 (Entrez Gene)
HAND2GeneProduct9464 (Entrez Gene)
HEY1GeneProduct23462 (Entrez Gene)
HEY2GeneProduct23493 (Entrez Gene)
IRX4GeneProduct50805 (Entrez Gene)
ISL1GeneProduct3670 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MIR1-1GeneProductENSG00000199017 (Ensembl Human)
MIR143GeneProductENSG00000208035 (Ensembl Human)
MIR145GeneProductENSG00000207700 (Ensembl Human)
NFATC1GeneProduct4772 (Entrez Gene)
NFATC2GeneProduct4773 (Entrez Gene)
NFATC3GeneProduct4775 (Entrez Gene)
NFATC4GeneProduct4776 (Entrez Gene)
NKX2-5GeneProduct1482 (Entrez Gene)
NOTCH1GeneProduct4851 (Entrez Gene)
PITX2GeneProduct5308 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
SHHGeneProduct6469 (Entrez Gene)
SMAD1GeneProduct4086 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SMYD1GeneProduct150572 (Entrez Gene)
SRFGeneProduct6722 (Entrez Gene)
TBX1GeneProduct6899 (Entrez Gene)
TBX20GeneProduct57057 (Entrez Gene)
TBX2GeneProduct6909 (Entrez Gene)
TBX5GeneProduct6910 (Entrez Gene)
VEGFAGeneProduct7422 (Entrez Gene)
VEGFBGeneProduct7423 (Entrez Gene)
VEGFCGeneProduct7424 (Entrez Gene)

Annotated Interactions

No annotated interactions

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