Combined Pathways (Network) for Cellulose Digestion (Clostridium thermocellum)
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1
ABC
Transporter
3
Lactate
L-Lactate Dehydrogenase
Pyruvate
AcetylCoA
Cellulose
Cellobiose
D-Glucose
Glucose-6-Phosphate
Fructose-6-Phosphate
Fructose-1,6-Biphosphate
Glyceraldehyde 3-phosphate
Dihydroxyacetone phosphate
Bisphosphoglyceric acid
3-Phosphoglyceric acid
2-Phosphoglyceric acid
phosphoenolpyruvate
Endoglucanase
2
Cellobiose Phosphorylase
Glucokinase
Glucose-6-phosphate Isomerase
6-Phosphofructokinase
Fructose-bisphosphate Aldolase
Glyceraldehyde-3-Phosphate Dehydrogense
Triosephosphate Isomerase
Phosphoglycerate mutase
Pyruvate:fd Oxioreductase ɤ
AMP-dependent synthetase and ligase
Ethanol
Acetaldhyde Dehydrogenase/Alcohol Dehydrogenase
Ferredoxin - Ox
Ferodoxin - Re
Ferrodoxin
H2
NADH dehydrogenase (ubquinone)
H+
NADP+
NADPH
Formate
Formate acetyltransferase
NADP+
NADP+
NADPH
NADPH
ATP
ADP
ATP
ADP
NAD+
NADH
ATP
ADP
Acetate
ATP
AMP
Pi
α-D-glucose 1-phosphate
α-Phosphoglucomutase
Cellotriose
D-Cellotetraose
Cellobiose
Cellotriose
D-Cellotetraose
Innermembrane Translocator
Inner-membrane translocator
binding-protein
binding-protein
binding-protein
binding-protein
ABC-type sugar
extracellular solute-binding protein
extracellular solute-binding protein
ATPase
phosphoglycerate mutase
ABC transporter-like protein
ABC transporter
ABC transporter-like protein
ABC transporter-like protein
(ATPase component)
ATP
ADP
Phosphoglyceromutase
Phosphoglycerare mutase
Phosphoglycerate mutase
Eno Phosphopyruvate Hydratase
Oxaloacetic Acid
Phosphoenolpyruvate Carboxykinase
Carboxyl transferase
Biotin/lipoyl attachment protein
Oxaloacetate Decarboxylase
C02
Malate
Malate Dehydrogenase (NAD)
NAD+
NADH
Malate Dehydrogenase
Phosphoenolpyruvate Synthase
Pyruvate:fd Oxidoreductase δ
Pyruvate:fd Oxioreductase α
Peptide Chain Release Factor 1
Pyruvate:fl/fd Oxioreductase-Like
Pyruvate:fl/fd Oxioreductase-like
Indolepyruvate oxidoreductase subunit ɗ
Pyruvate formate-lyase activating enzyme
C02
Acetaldehyde
Fe-Containing ADH
Fe-Containing ADH
NADPH
NADP+
Pii
Glycogen, Starch
Glycogen Debranching Enzyme
Glycogen, Amylase (1,4-α)
1,4-α-Branching Enzyme
α-Glucan Phosphorylase
Pi
ADP-Glucose
Glucose-1-phosphate adenylyltransferase
GlgD subunit
ADP-glucose type glycogen/starch synthase
ADP-glucose type glycogen/starch synthase
ADP
ATP
Glycosyltransferase
Glycosyltransferase
PPi
PPi
Pi
6-Phosphofructokinase
PfkB
NADH dehydrogenase (quinone)
hydrogenase, Fe-only
NADH dehydrogenase (quinone)
Hydrogenase, Fe-only
NAD+
NADH
Description
No description
Comments
Metabolically deduced pathway of pyruvate catabolism in Clositridium thermocellum ATCC 27405.
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Bibliography
History
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Compare
Revision
Action
Time
User
Comment
50507
view
19:36, 16 August 2012
MaintBot
Deleted pathway: request by author; she plans to resubmit after publication
47939
view
20:38, 19 April 2012
Bjorklund
Fxing ABC transporter
47938
view
20:31, 19 April 2012
Bjorklund
Periodical save, work in progress
47937
view
20:28, 19 April 2012
Bjorklund
Fixing the ABC transporter
47735
view
17:45, 4 April 2012
Bjorklund
Added a reference to alpha phosphoglucomutase
47730
view
16:49, 4 April 2012
Bjorklund
Modified title
47673
view
19:14, 2 April 2012
Bjorklund
Modified description
47672
view
19:12, 2 April 2012
Bjorklund
Modified description
47662
view
18:20, 2 April 2012
Bjorklund
Modified title
46993
view
16:31, 9 March 2012
Bjorklund
Added missing Phosphoglycerate kinase
46976
view
18:44, 8 March 2012
Bjorklund
Periodical save, work in progress
46975
view
18:33, 8 March 2012
Bjorklund
Periodical save, work in progress
46883
view
20:45, 5 March 2012
Bjorklund
Touchup
46882
view
20:42, 5 March 2012
Bjorklund
Pathway Completed First Draft
46872
view
18:55, 5 March 2012
Bjorklund
Periodical save, work in progress
46871
view
18:45, 5 March 2012
Bjorklund
Periodical save, work in progress
46870
view
18:28, 5 March 2012
Bjorklund
Periodical save, work in progress
46868
view
18:18, 5 March 2012
Bjorklund
Periodical save, work in progress
46867
view
18:08, 5 March 2012
Bjorklund
Periodical save, work in progress
46866
view
17:57, 5 March 2012
Bjorklund
Periodical save, work in progress
46865
view
17:47, 5 March 2012
Bjorklund
Periodical save, work in progress
46864
view
17:37, 5 March 2012
Bjorklund
Periodical save, work in progress
46863
view
17:17, 5 March 2012
Bjorklund
Periodical save, work in progress
46843
view
02:26, 3 March 2012
AlexanderPico
Reverted to version '12:19, 2 March 2012' by
AlexanderPico
46842
view
02:18, 3 March 2012
AlexanderPico
Reverted to version '12:29, 2 March 2012' by
AlexanderPico
46837
view
19:34, 2 March 2012
Bjorklund
More undating
46836
view
19:29, 2 March 2012
Bjorklund
Periodical save, work in progress
46835
view
19:19, 2 March 2012
Bjorklund
Periodical save, work in progress
46834
view
19:09, 2 March 2012
Bjorklund
Periodical save, work in progress
46833
view
18:59, 2 March 2012
Bjorklund
Periodical save, work in progress
46832
view
18:48, 2 March 2012
Bjorklund
Periodical save, work in progress
46831
view
18:38, 2 March 2012
Bjorklund
Periodical save, work in progress
46830
view
18:28, 2 March 2012
Bjorklund
Periodical save, work in progress
46829
view
18:18, 2 March 2012
Bjorklund
Periodical save, work in progress
46828
view
18:08, 2 March 2012
Bjorklund
Periodical save, work in progress
46827
view
17:37, 2 March 2012
Bjorklund
Periodical save, work in progress
46826
view
17:27, 2 March 2012
Bjorklund
Periodical save, work in progress
46825
view
17:17, 2 March 2012
Bjorklund
Periodical save, work in progress
46824
view
17:07, 2 March 2012
Bjorklund
Periodical save, work in progress
46823
view
16:45, 2 March 2012
Bjorklund
Periodical save, work in progress
46814
view
03:35, 2 March 2012
Bjorklund
Periodical save, work in progress
46809
view
00:03, 2 March 2012
Bjorklund
Continuing to work on the pathways
46808
view
23:54, 1 March 2012
Bjorklund
Periodical save, work in progress
46807
view
23:43, 1 March 2012
Bjorklund
Periodical save, work in progress
46806
view
23:33, 1 March 2012
Bjorklund
Periodical save, work in progress
46805
view
23:23, 1 March 2012
Bjorklund
Periodical save, work in progress
46804
view
23:13, 1 March 2012
Bjorklund
Periodical save, work in progress
46803
view
23:03, 1 March 2012
Bjorklund
Periodical save, work in progress
46802
view
22:53, 1 March 2012
Bjorklund
Periodical save, work in progress
46801
view
22:43, 1 March 2012
Bjorklund
Periodical save, work in progress
External references
DataNodes
View all...
Name
Type
Database reference
Comment
1,4-α-Branching Enzyme
GeneProduct
4810907 (Entrez Gene)
Cthe 2191, 1,4-α-Debranching Enzyme
2-Phosphoglyceric acid
Metabolite
2553-59-5 (CAS)
3-Phosphoglyceric acid
Metabolite
17794 (ChEBI)
6-Phosphofructokinase
GeneProduct
4808496 (Entrez Gene)
Cthe 0347
6-Phosphofructokinase
GeneProduct
4809766 (Entrez Gene)
Cthe 1261
ABC transporter-like protein (ATPase component)
Protein
4809413 (Entrez Gene)
Cthe 2128 (sugar binding periplasmic protein
ABC transporter-like protein
Protein
4809826 (Entrez Gene)
Cthe 2447
ABC transporter-like protein
Protein
4811175 (Entrez Gene)
Cthe 0391 ABC transporter-like protein putative sugar ABC transporter ATP-binding protein
ABC transporter
Protein
4808396 (Entrez Gene)
Cthe 0393 sugar ABC transporter sugar-binding protein
ABC-type sugar
Protein
4809825 (Entrez Gene)
Cthe 2446 ABC-type sugar transport system periplasmic component-like protein (D-ribose transport system ATP-binding protein)
ADP-Glucose
Metabolite
15751 (ChEBI)
ADP-glucose type glycogen/starch synthase
GeneProduct
4808565 (Entrez Gene)
Cthe 0282, ADP-glucose type glycogen/starch synthase
ADP-glucose type glycogen/starch synthase
GeneProduct
4809536 (Entrez Gene)
Cthe 1284, ADP-glucose type glycogen/starch synthase
ADP
Metabolite
58-64-0 (ChEBI)
AMP-dependent synthetase and ligase
Protein
19926-71-7 (CAS)
Cthe 0551, Acetate Thiokinase
AMP
Metabolite
61-19-8 (CAS)
ATP
Metabolite
56-65-5 (ChEBI)
ATPase
Protein
4811174 (Entrez Gene)
MoxR-like ATPases
Acetaldehyde
Metabolite
75-07-0 (CAS)
Acetaldhyde Dehydrogenase/Alcohol Dehydrogenase
GeneProduct
4808426 (Entrez Gene)
Cthe 0423
Acetate
Metabolite
758-12-3 (CAS)
AcetylCoA
Metabolite
72-89-9 (CAS)
Biotin/lipoyl attachment protein
Protein
4810318 (Entrez Gene)
Cthe 0700
Bisphosphoglyceric acid
Metabolite
1981-49-3 (CAS)
C02
Metabolite
124-38-9 (CAS)
Carboxyl transferase
Protein
4810317 (Entrez Gene)
Cthe 0699
Cellobiose Phosphorylase
GeneProduct
4808558 (Entrez Gene)
Cthe 0275
Cellobiose
Metabolite
17057 (ChEBI)
Cellotriose
Metabolite
33404-34-1 (CAS)
Cellulose
Metabolite
18246 (ChEBI)
D-Cellotetraose
Metabolite
38819-01-1 (CAS)
D-Glucose
Metabolite
4146 (ChEBI)
Dihydroxyacetone phosphate
Metabolite
57-04-5 (CAS)
Endoglucanase
GeneProduct
4808805 (Entrez Gene)
Eno Phosphopyruvate Hydratase
GeneProduct
4808701 (Entrez Gene)
Enolase Cthe 0143
Ethanol
Metabolite
64-17-5 (CAS)
Fe-Containing ADH
GeneProduct
4808397 (Entrez Gene)
Cthe 0394, iron-containing alcohol dehydrogenase
Fe-Containing ADH
GeneProduct
4808725 (Entrez Gene)
Cthe 0101, iron-containing alcohol dehydrogenase
Ferodoxin - Re
GeneProduct
4810104 (Entrez Gene)
Enolase
Ferredoxin - Ox
GeneProduct
4810104 (Entrez Gene)
Enolase
Ferrodoxin
GeneProduct
4808489 (Entrez Gene)
Cthe 0340,
Formate acetyltransferase
GeneProduct
4808305 (Entrez Gene)
Cthe 0505, Pyruvate:Formate Lyase (& AE)
Formate
Metabolite
15740 (ChEBI)
Fructose-1,6-Biphosphate
Metabolite
488-69-7 (CAS)
Fructose-6-Phosphate
Metabolite
643-13-0 (CAS)
Fructose-bisphosphate Aldolase
GeneProduct
4808498 (Entrez Gene)
Cthe 0349, (Cthe 2938 no protein detected)
GlgD subunit
GeneProduct
4809617 (Entrez Gene)
Cthe_3167, glucose-1-phosphate adenylyltransferase, GlgD subunit
Glucokinase
GeneProduct
4810221 (Entrez Gene)
hexokinase, Cthe 2938, (Cthe 0390 no dectable protein)
Glucose-1-phosphate adenylyltransferase
GeneProduct
4809616 (Entrez Gene)
Cthe 3166, glgC glucose-1-phosphate adenylyltransferase
Glucose-6-Phosphate
Metabolite
4170 (ChEBI)
Glucose-6-phosphate Isomerase
GeneProduct
4808635 (Entrez Gene)
Cthe 0217
Glyceraldehyde 3-phosphate
Metabolite
142-10-9 (CAS)
Glyceraldehyde-3-Phosphate Dehydrogense
GeneProduct
4808695 (Entrez Gene)
Cthe 0137
Glycogen Debranching Enzyme
GeneProduct
4808741 (Entrez Gene)
Cthe 0115, 1,4-a-Debranching Enzyme
Glycogen, Amylase (1,4-α)
Metabolite
9014-71-5 (CAS)
Glycogen, Starch
Metabolite
HMDB00757 (HMDB)
Glycosyltransferase
GeneProduct
4809913 (Entrez Gene)
Cthe 1221
Glycosyltransferase
GeneProduct
4811137 (Entrez Gene)
Cthe 2989
H+
Metabolite
12408-02-5 (CAS)
H2
Metabolite
1333-74-0 (CAS)
Hydrogenase, Fe-only
GeneProduct
4808491 (Entrez Gene)
Cthe 0342
Indolepyruvate oxidoreductase subunit ɗ
GeneProduct
4808216 (Entrez Gene)
Cthe 0614, indolepyruvate oxidoreductase subunit beta
Inner-membrane translocator
Protein
4808395 (Entrez Gene)
Innermembrane Translocator
Protein
4809827 (Entrez Gene)
Cthe 2448
L-Lactate Dehydrogenase
GeneProduct
4811351 (Entrez Gene)
Cthe 1053
Lactate
Metabolite
16651 (ChEBI)
Malate Dehydrogenase (NAD)
GeneProduct
4808494 (Entrez Gene)
Cthe 0345
Malate Dehydrogenase
GeneProduct
4808493 (Entrez Gene)
Cthe 0344
Malate
Metabolite
6915-15-7 (CAS)
NAD+
Metabolite
53-54-9 (CAS)
NADH dehydrogenase (quinone)
GeneProduct
4808357 (Entrez Gene)
Cthe 0429
NADH dehydrogenase (quinone)
GeneProduct
4808490 (Entrez Gene)
Cthe 0341
NADH dehydrogenase (ubquinone)
GeneProduct
4808431 (Entrez Gene)
Cthe 0428, NADH dehydrogenase (ubiquinone), 24 kDa subunit
NADH
Metabolite
53-68-4 (CAS)
NADP+
Metabolite
53-59-8 (CAS)
NADPH
Metabolite
53-59-8 (CAS)
Oxaloacetate Decarboxylase
Protein
4810319 (Entrez Gene)
Cthe 0701
Oxaloacetic Acid
Metabolite
328-42-7 (CAS)
PPi
Metabolite
18361 (ChEBI)
Peptide Chain Release Factor 1
GeneProduct
4809015 (Entrez Gene)
Cthe 2593
PfkB
GeneProduct
4808466 (Entrez Gene)
Cthe 0389,
Phosphoenolpyruvate Carboxykinase
Protein
4809154 (Entrez Gene)
Cthe 2874
Phosphoenolpyruvate Synthase
Protein
4809758 (Entrez Gene)
Cthe 1253
Phosphoglycerare mutase
GeneProduct
4810325 (Entrez Gene)
Cthe 707
Phosphoglycerate mutase
GeneProduct
4809544 (Entrez Gene)
Cthe 1292
Phosphoglycerate mutase
GeneProduct
4811239 (Entrez Gene)
Cthe 0946
Phosphoglyceromutase
GeneProduct
4808698 (Entrez Gene)
Cthe 0140
Pi
Metabolite
14265-44-2 (CAS)
Pii
Metabolite
14265-44-2 (CAS)
Pyruvate formate-lyase activating enzyme
GeneProduct
4808306 (Entrez Gene)
Cthe 0505, Pyruvate formate-lyase activating enzyme
Pyruvate
Metabolite
127-17-3 (CAS)
Pyruvate:fd Oxidoreductase δ
GeneProduct
4811043 (Entrez Gene)
Cthe 2392
Pyruvate:fd Oxioreductase ɤ
GeneProduct
4811042 (Entrez Gene)
Cthe 2390
Pyruvate:fd Oxioreductase α
GeneProduct
4811044 (Entrez Gene)
Cthe 2392
Pyruvate:fl/fd Oxioreductase-Like
GeneProduct
4809683 (Entrez Gene)
Cthe 3120, pyruvate flavodoxin/ferredoxin oxidoreductase-like protein
Pyruvate:fl/fd Oxioreductase-like
GeneProduct
4810484 (Entrez Gene)
Cthe 0866, pyruvate flavodoxin/ferredoxin oxidoreductase-like protein
Triosephosphate Isomerase
GeneProduct
4808697 (Entrez Gene)
Cthe 0347
binding-protein
Protein
4811172 (Entrez Gene)
Cthe 2125, binding-protein-dependent transport systems inner membrane component (permease component)
Type your comment here
binding-protein
Protein
4811173 (Entrez Gene)
Cthe 2126, binding-protein-dependent transport systems inner membrane component (permease component)
binding-protein
Protein
4811312 (Entrez Gene)
Cthe 1018, binding-protein-dependent transport systems inner membrane component (sugar ABC transporter, permease protein)
Type your comment here
binding-protein
Protein
4811313 (Entrez Gene)
Cthe 1019, binding-protein-dependent transport systems inner membrane component, putative transmembrane sugar transport protein
Type your comment here
extracellular solute-binding protein
Protein
4811175 (Entrez Gene)
Cthe 2128 (sugar binding periplasmic protein
extracellular solute-binding protein
Metabolite
4811314 (ChEBI)
Cthe 1020
hydrogenase, Fe-only
GeneProduct
4808358 (Entrez Gene)
Cthe 0430
phosphoenolpyruvate
Metabolite
138-08-9 (CAS)
phosphoglycerate mutase
Protein
4809828 (Entrez Gene)
Location in ABC Transporter not specified.
α-D-glucose 1-phosphate
Metabolite
59-56-3 (CAS)
α-Glucan Phosphorylase
GeneProduct
4808434 (Entrez Gene)
Cthe 0357, alpha-glucan phosphorylases
α-Phosphoglucomutase
GeneProduct
4809770 (Entrez Gene)
Annotated Interactions
No annotated interactions
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