Apoptosis (Gallus gallus)

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2IGF1R signaling pathwaybMitochondrionCaspActivator of Cell DeathppeDNA FragmentationInhibitor of Cell Deathp53 RelatedInterferon regulatory factorsFas LigandbbeApoptosisDegradationPIK3R1CYCSBOKTNFRSF1BTNFPMAIP1IKBKBLOC100858419BBC3TNFRSF1AMDM2GZMBTNFRSF25NFKBIANFKB1BCL2L1BCL2L2BCL2FADDIRF6CASP9CDKN2ACRADDBNIP3LNFKB1DIABLOCASP4IRF1HRKBADIGF2TNFRSF21MAP3K1CASP7CYCTCHUKFASLGTNFRSF10BMCL1IRF5DFFARIPK1TRADDAPAF1PRF1MAP2K4TRAF1AKT1IKBKGBCL2L11IGF1RIGF1CASP1HELLSRELACASP11BIRC5MYCTRAF2TRADDTP53BIRC2BAXMAPK10LOC100858419TP63CASP2BIRC3BAK1FASIRF2IRF7LOC421438DFFBTP73LTANFKBIATNFSF10BADIRF3BIDCASP3CFLARRELACASP8TNFRSF1ARIPK1XIAPCASP10LOC421438IRF4CASP6JUNTRAF31


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP254(r41184) with a 77% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia
  2. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia
  3. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  4. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  5. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95787view14:37, 19 January 2018MkutmonHomology conversion update
67051view09:59, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
62332view16:49, 27 April 2013EgonwOnly move MDM2.
62331view16:48, 27 April 2013EgonwUndo revision 62330 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
62330view16:46, 27 April 2013EgonwMoved MDM2 and did an undo.
48121view05:10, 9 May 2012KhanspersUpdating from human to fix xref duplication
47795view16:34, 6 April 2012Khanspersupdated xref
41016view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
33937view18:12, 9 December 2009MaintBotAutomatic update of empty xrefs
33465view15:03, 30 November 2009MaintBotRemoved group label
30356view20:54, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene)
APAF1GeneProduct417926 (Entrez Gene)
BADGeneProduct
BAK1GeneProduct419912 (Entrez Gene)
BAXGeneProduct
BBC3GeneProduct
BCL2GeneProduct396282 (Entrez Gene)
BCL2L11GeneProduct
BCL2L1GeneProduct373954 (Entrez Gene)
BCL2L2GeneProduct
BIDGeneProduct395236 (Entrez Gene)
BIRC2GeneProduct374012 (Entrez Gene)
BIRC3GeneProduct
BIRC5GeneProduct374078 (Entrez Gene)
BNIP3LGeneProduct419522 (Entrez Gene)
BOKGeneProduct395445 (Entrez Gene)
CASP10GeneProduct424081 (Entrez Gene)
CASP11GeneProduct
CASP1GeneProduct395764 (Entrez Gene)
CASP2GeneProduct395857 (Entrez Gene)
CASP3GeneProduct395476 (Entrez Gene)
CASP4GeneProduct
CASP6GeneProduct395477 (Entrez Gene)
CASP7GeneProduct423901 (Entrez Gene)
CASP8GeneProduct395284 (Entrez Gene)
CASP9GeneProduct426970 (Entrez Gene)
CDKN2AGeneProduct
CFLARGeneProduct424080 (Entrez Gene)
CHUKGeneProduct423669 (Entrez Gene)
CRADDGeneProduct417900 (Entrez Gene)
CYCSGeneProduct420624 (Entrez Gene)
CYCTGeneProduct
DFFAGeneProduct419451 (Entrez Gene)
DFFBGeneProduct374158 (Entrez Gene)
DIABLOGeneProduct416860 (Entrez Gene)
FADDGeneProduct423146 (Entrez Gene)
FASGeneProduct395274 (Entrez Gene)
FASLGGeneProduct429064 (Entrez Gene)
GZMBGeneProduct
HELLSGeneProduct423750 (Entrez Gene)
HRKGeneProduct
IGF1GeneProduct418090 (Entrez Gene)
IGF1RGeneProduct395889 (Entrez Gene)
IGF2GeneProduct395097 (Entrez Gene)
IKBKBGeneProduct426792 (Entrez Gene)
IKBKGGeneProduct
IRF1GeneProduct396384 (Entrez Gene)
IRF2GeneProduct396115 (Entrez Gene)
IRF3GeneProduct
IRF4GeneProduct374179 (Entrez Gene)
IRF5GeneProduct430409 (Entrez Gene)
IRF6GeneProduct419863 (Entrez Gene)
IRF7GeneProduct
JUNGeneProduct424673 (Entrez Gene)
LOC100858419GeneProduct100858419 (Entrez Gene)
LOC421438GeneProduct421438 (Entrez Gene)
LTAGeneProduct
MAP2K4GeneProduct417312 (Entrez Gene)
MAP3K1GeneProduct427144 (Entrez Gene)
MAPK10GeneProduct422592 (Entrez Gene)
MCL1GeneProduct395674 (Entrez Gene)
MDM2GeneProduct395609 (Entrez Gene)
MYCGeneProduct420332 (Entrez Gene)
NFKB1GeneProduct396033 (Entrez Gene)
NFKBIAGeneProduct396093 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PMAIP1GeneProduct
PRF1GeneProduct
RELAGeneProduct396027 (Entrez Gene)
RIPK1GeneProduct378921 (Entrez Gene)
TNFGeneProduct
TNFRSF10BGeneProduct373904 (Entrez Gene)
TNFRSF1AGeneProduct418325 (Entrez Gene)
TNFRSF1BGeneProduct395083 (Entrez Gene)
TNFRSF21GeneProduct422062 (Entrez Gene)
TNFRSF25GeneProduct425564 (Entrez Gene)
TNFSF10GeneProduct378894 (Entrez Gene)
TP53GeneProduct
TP63GeneProduct374269 (Entrez Gene)
TP73GeneProduct419382 (Entrez Gene)
TRADDGeneProduct415700 (Entrez Gene)
TRAF1GeneProduct417123 (Entrez Gene)
TRAF2GeneProduct417287 (Entrez Gene)
TRAF3GeneProduct423471 (Entrez Gene)
XIAPGeneProduct395280 (Entrez Gene)

Annotated Interactions

No annotated interactions
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