Insulin Signaling (Pan troglodytes)

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1, 3Glucose TransportModulators of Insulin ActionPDK/Akt SignalingRas-MAPK SignalingMEK/MAP KinasesTranslation Regulationp70 S6 KinasesTranscriptional Regulators & Immediate Early GenesCell GrowthDifferentiationInsulin Receptor SubstratesTor Signalingp90 Rsk KinasesMetabolic RegulationVesicular TraffickingPI 3-Kinase isoformsMAPK6SGKLPFKLRAB4ASNAP25PRKCAPRKCIPTENSOCS1RRADCBLCCAP1INPPL1KIF5BSLC2A4MAP3K11RAC2MAP2K3PPP1R3AFOXO3MAP3K13MAP3K9LOC100611792PRKCHIRS2EHD2SOS2TRIB3GYS2MAPK7PIK3EHD1HRASPIK3C3LOC468536JUNLOC747077CRKPIK3R2PRKCBRPS6KA1PTPN1LOC471564TBC1D4MINK1RHEBMAPK3MAPK1LOC454062ENPP1CBLBARF6GRB2TSC2IRS3MAP3K12RAPGEF1MAP2K5CBLAKT2PRKCQPIK3CAMAP3K7PDPK1INSRSH2B2LIPERPS6KB1LOC100613619LOC473846STXBP3PRKAA2SNAP23MAP4K4STXBP1MAPK8MAP3K10MAP2K4ARF1PRKCZSRFKIF3AREG1ATSC1RAF1AKT1PIK3R1MAP3K6GYG1MAPK9PRKCDRPS6KB2RPS6KA2MYO1CFLOT1MAP3K8IRS1RPS6KA5PIK3CDMAP4K1PIK3R4FLOT2LOC468286PSCD3PIK3C2AGRB10PIK3C2GIRS1LOC463119GYS1STXBP2PIK3CGSOCS3LOC741907MAP3K2INPP4ASNX26STXBP4SOS1PFKMMAP2K6MAP2K1FRAP1PIK3R3EGR1GRB14IGF1RMAPK10SORBS1MAP3K14VAMP2LOC100616510PTPRFMAP4K2IKBKBRHOJSGK1GSK3AMAP3K5SHC2RPS6KA3EIF4ESGK2MAP3K1MAP2K7PTPN11SHC3MAPK11RPS6KA6FOSPIK3CBFOXO1GAB1ELK1XBP1MAPK14MAPK8MAP4K5RHOQEIF4EBP1MAPK13SHC1MAP4K3RPS6KA42


Description

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP481(r45380) with a 87% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia
  2. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia
  3. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
69319view18:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
48148view18:41, 9 May 2012MaintBotUpdating from human to fix xrefs
41629view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
34356view22:24, 9 December 2009MaintBotAutomatic update of empty xrefs
33517view15:19, 30 November 2009MaintBotRemoved group label
31557view21:54, 13 August 2009MaintBotFixed text labels
30416view21:15, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct
AKT2GeneProduct456035 (Entrez Gene)
ARF1GeneProduct
ARF6GeneProduct452892 (Entrez Gene)
CAP1GeneProduct746432 (Entrez Gene)
CBLGeneProduct451690 (Entrez Gene)
CBLBGeneProduct460566 (Entrez Gene)
CBLCGeneProduct
CRKGeneProduct747142 (Entrez Gene)
EGR1GeneProduct462097 (Entrez Gene)
EHD1GeneProduct744047 (Entrez Gene)
EHD2GeneProduct456170 (Entrez Gene)
EIF4EGeneProduct461391 (Entrez Gene)
EIF4EBP1GeneProduct464114 (Entrez Gene)
ELK1GeneProduct
ENPP1GeneProduct463002 (Entrez Gene)
FLOT1GeneProduct471961 (Entrez Gene)
FLOT2GeneProduct454537 (Entrez Gene)
FOSGeneProduct453047 (Entrez Gene)
FOXO1GeneProduct467352 (Entrez Gene)
FOXO3GeneProduct462921 (Entrez Gene)
FRAP1GeneProduct
GAB1GeneProduct461516 (Entrez Gene)
GRB10GeneProduct463410 (Entrez Gene)
GRB14GeneProduct459695 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
GSK3AGeneProduct456071 (Entrez Gene)
GYG1GeneProduct460765 (Entrez Gene)
GYS1GeneProduct456196 (Entrez Gene)
GYS2GeneProduct465336 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
IGF1RGeneProduct453676 (Entrez Gene)
IKBKBGeneProduct472749 (Entrez Gene)
INPP4AGeneProduct470448 (Entrez Gene)
INPPL1GeneProduct451403 (Entrez Gene)
INSRGeneProduct455650 (Entrez Gene)
IRS1GeneProduct459985 (Entrez Gene)
IRS2GeneProduct452657 (Entrez Gene)
IRS3GeneProduct
JUNGeneProduct456893 (Entrez Gene)
KIF3AGeneProduct450168 (Entrez Gene)
KIF5BGeneProduct450390 (Entrez Gene)
LIPEGeneProduct456076 (Entrez Gene)
LOC100611792GeneProduct100611792 (Entrez Gene)
LOC100613619GeneProduct100613619 (Entrez Gene)
LOC100616510GeneProduct100616510 (Entrez Gene)
LOC454062GeneProduct454062 (Entrez Gene)
LOC463119GeneProduct463119 (Entrez Gene)
LOC468286GeneProduct468286 (Entrez Gene)
LOC468536GeneProduct468536 (Entrez Gene)
LOC471564GeneProduct471564 (Entrez Gene)
LOC473846GeneProduct473846 (Entrez Gene)
LOC741907GeneProduct741907 (Entrez Gene)
LOC747077GeneProduct747077 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K3GeneProduct454515 (Entrez Gene)
MAP2K4GeneProduct455065 (Entrez Gene)
MAP2K5GeneProduct453532 (Entrez Gene)
MAP2K6GeneProduct468310 (Entrez Gene)
MAP2K7GeneProduct743199 (Entrez Gene)
MAP3K10GeneProduct
MAP3K11GeneProduct451326 (Entrez Gene)
MAP3K12GeneProduct451940 (Entrez Gene)
MAP3K13GeneProduct737524 (Entrez Gene)
MAP3K14GeneProduct454750 (Entrez Gene)
MAP3K1GeneProduct471543 (Entrez Gene)
MAP3K2GeneProduct736244 (Entrez Gene)
MAP3K5GeneProduct463023 (Entrez Gene)
MAP3K6GeneProduct456674 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAP3K8GeneProduct450384 (Entrez Gene)
MAP3K9GeneProduct467498 (Entrez Gene)
MAP4K1GeneProduct748652 (Entrez Gene)
MAP4K2GeneProduct451301 (Entrez Gene)
MAP4K3GeneProduct459173 (Entrez Gene)
MAP4K4GeneProduct459459 (Entrez Gene)
MAP4K5GeneProduct467451 (Entrez Gene)
MAPK10GeneProduct461358 (Entrez Gene)
MAPK11GeneProduct
MAPK13GeneProduct462644 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK6GeneProduct453439 (Entrez Gene)
MAPK7GeneProduct454499 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
MINK1GeneProduct454455 (Entrez Gene)
MYO1CGeneProduct750403 (Entrez Gene)
PDPK1GeneProduct
PFKLGeneProduct458602 (Entrez Gene)
PFKMGeneProduct451863 (Entrez Gene)
PIK3GeneProduct
PIK3C2AGeneProduct451052 (Entrez Gene)
PIK3C2GGeneProduct
PIK3C3GeneProduct455385 (Entrez Gene)
PIK3CAGeneProduct460858 (Entrez Gene)
PIK3CBGeneProduct
PIK3CDGeneProduct457922 (Entrez Gene)
PIK3CGGeneProduct463649 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PIK3R3GeneProduct456565 (Entrez Gene)
PIK3R4GeneProduct460692 (Entrez Gene)
PPP1R3AGeneProduct463666 (Entrez Gene)
PRKAA2GeneProduct741802 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PRKCBGeneProduct453993 (Entrez Gene)
PRKCDGeneProduct460442 (Entrez Gene)
PRKCHGeneProduct746068 (Entrez Gene)
PRKCIGeneProduct450143 (Entrez Gene)
PRKCQGeneProduct450288 (Entrez Gene)
PRKCZGeneProduct743533 (Entrez Gene)
PSCD3GeneProduct
PTENGeneProduct466142 (Entrez Gene)
PTPN11GeneProduct
PTPN1GeneProduct469970 (Entrez Gene)
PTPRFGeneProduct456828 (Entrez Gene)
RAB4AGeneProduct
RAC2GeneProduct
RAF1GeneProduct460182 (Entrez Gene)
RAPGEF1GeneProduct464812 (Entrez Gene)
REG1AGeneProduct459348 (Entrez Gene)
RHEBGeneProduct463880 (Entrez Gene)
RHOJGeneProduct452960 (Entrez Gene)
RHOQGeneProduct740809 (Entrez Gene)
RPS6KA1GeneProduct456664 (Entrez Gene)
RPS6KA2GeneProduct463127 (Entrez Gene)
RPS6KA3GeneProduct450110 (Entrez Gene)
RPS6KA4GeneProduct451715 (Entrez Gene)
RPS6KA5GeneProduct739162 (Entrez Gene)
RPS6KA6GeneProduct
RPS6KB1GeneProduct468426 (Entrez Gene)
RPS6KB2GeneProduct746903 (Entrez Gene)
RRADGeneProduct741038 (Entrez Gene)
SGK1GeneProduct463011 (Entrez Gene)
SGK2GeneProduct740699 (Entrez Gene)
SGKLGeneProduct
SH2B2GeneProduct741557 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
SHC2GeneProduct
SHC3GeneProduct450176 (Entrez Gene)
SLC2A4GeneProduct468443 (Entrez Gene)
SNAP23GeneProduct453365 (Entrez Gene)
SNAP25GeneProduct458096 (Entrez Gene)
SNX26GeneProduct
SOCS1GeneProduct737070 (Entrez Gene)
SOCS3GeneProduct454921 (Entrez Gene)
SORBS1GeneProduct450628 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
SOS2GeneProduct452897 (Entrez Gene)
SRFGeneProduct462709 (Entrez Gene)
STXBP1GeneProduct464750 (Entrez Gene)
STXBP2GeneProduct741963 (Entrez Gene)
STXBP3GeneProduct737947 (Entrez Gene)
STXBP4GeneProduct468411 (Entrez Gene)
TBC1D4GeneProduct467286 (Entrez Gene)
TRIB3GeneProduct
TSC1GeneProduct464818 (Entrez Gene)
TSC2GeneProduct468086 (Entrez Gene)
VAMP2GeneProduct747237 (Entrez Gene)
XBP1GeneProduct458735 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP847"
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