Regulation of immune response in the intestine (Caenorhabditis elegans)

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1p38 MAPK modulePIP2intestineTIR-1TPA-1DFK-2protein kinase DDAF-2NSY-1EGL-30INS-7FSHR-1EGL-8GOA-1DGK-1DAGPAEGL-30EGL-8PIP2DAGAKT-1AKT-2SGK-1DAF-16DAF-16ETS-4ELT-2ATF-7LYS-7SPP-1T24B8.5LYS-2ZIP-2C07G3.2SEK-1PMK-1neuron


Description

"Cell- and non-cell-autonomous regulation of immune responses in the intestine. The IIS pathway (blue letters and arrows) is regulated

primarily by the insulin peptide released from the neurones. In the intestine, activity of IIS determines the subcellular localization of DAF-16. Whether ELT-2 and ETS-4 cooperate with DAF-16 to regulate gene transcription remains to be determined. A separate G-protein signalling pathway modulates the activity of the p38 MAPK (black letters and arrows) module through a series of enzymes that include phospholipases, which determines the level of diacylglycerol (DAG), and protein kinase C (TPA-1) and protein kinase D (DFK-2). ATF-7 is the transcription factor that mediates p38 MAPK signalling but how it is co-ordinated with other transcription to orchestrated immune gene expression remains unclear. ZIP-2 appears to regulate immunity independently of p38 MAPK signalling. With the exception of FSHR-1, which functions in parallel to p38 MAPK signalling, the G-protein-coupled receptors that engage Goa and Gqa signalling to affect immune function are currently

unknown. See text for detail."

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Bibliography

  1. Tan MW, Shapira M; ''Genetic and molecular analysis of nematode-microbe interactions.''; Cell Microbiol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135387view12:05, 3 September 2024EgonwModified description
135365view05:11, 2 September 2024EgonwConverted to use Ensembl identifiers
118399view14:10, 27 May 2021RaatsSfixed unconnected lines
80230view20:58, 27 May 2015KyookModified title
68498view21:09, 5 July 2013MaintBotUpdated to 2013 gpml schema
53142view02:07, 30 October 2012MaintBotModified categories
50938view23:19, 24 August 2012KyookModified description
49230view19:42, 9 July 2012KyookModified description
49229view19:42, 9 July 2012Kyookchanges arrow and gene colors
49228view19:34, 9 July 2012KyookModified description
49227view19:34, 9 July 2012KyookOntology Term : 'signaling pathway in the innate immune response' added !
49226view19:34, 9 July 2012KyookOntology Term : 'innate immune response pathway' added !
49225view19:33, 9 July 2012Kyookfinished
49224view19:32, 9 July 2012KyookPeriodical save, work in progress
49222view19:22, 9 July 2012KyookPeriodical save, work in progress
49217view18:51, 9 July 2012KyookPeriodical save, work in progress
49215view18:40, 9 July 2012KyookPeriodical save, work in progress
49213view18:30, 9 July 2012KyookPeriodical save, work in progress
49210view18:10, 9 July 2012KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT-1GeneProductC12D8.10 (WormBase)
AKT-2GeneProductF28H6.1 (WormBase)
ATF-7GeneProductC07G2.2 (WormBase)
C07G3.2GeneProductC07G3.2 (WormBase)
DAF-16GeneProductR13H8.1 (WormBase)
DAF-2GeneProductY55D5A.5 (WormBase)
DFK-2 protein kinase DProtein
DGK-1GeneProductC09E10.2 (WormBase)
EGL-30GeneProductM01D7.7 (WormBase)
EGL-8GeneProductB0348.4 (WormBase)
ELT-2GeneProductC33D3.1 (WormBase)
ETS-4GeneProductF22A3.1 (WormBase)
FSHR-1GeneProductC50H2.1 (WormBase)
GOA-1GeneProductC26C6.2 (WormBase)
INS-7GeneProductZK1251.2 (WormBase)
LYS-2GeneProductY22F5A.5 (WormBase)
LYS-7GeneProductC02A12.4 (WormBase)
NSY-1GeneProductF59A6.1 (WormBase)
PMK-1GeneProductB0218.3 (WormBase)
SEK-1GeneProductR03G5.2 (WormBase)
SGK-1GeneProductW10G6.2 (WormBase)
SPP-1GeneProductT07C4.4 (WormBase)
T24B8.5GeneProductT24B8.5 (WormBase)
TIR-1GeneProductF13B10.1 (WormBase)
TPA-1GeneProductB0545.1 (WormBase)
ZIP-2GeneProductK02F3.4 (WormBase)

Annotated Interactions

No annotated interactions

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