Male mating (Caenorhabditis elegans)

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558412, 5344ciliummale sensory neuronSTAM-1/STAMHGSRS-1/Hrs8CIL-1UnknownCWP-55ASB-13OSM-1PI(3,5)P2DAF-10ATP-23PI3POSM-51LOV-1/PC-12, 4, 6LOV-1/PC-12-4, 6PKD-2/PC-22, 4, 6CHE-11OSM-61KAP-11LOV-16PKD-22, 6CWP-55PKD-2/PC-22, 4, 653ATP-23ASG-13ASG-13ASB-1311ciliary transition zone24


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Bibliography

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  1. Barr MM, Garcia LR; ''Male mating behavior.''; WormBook, 2006 PubMed Europe PMC Scholia
  2. Lipton J; ''Mating worms and the cystic kidney: Caenorhabditis elegans as a model for renal disease.''; Pediatr Nephrol, 2005 PubMed Europe PMC Scholia
  3. Müller RU, Zank S, Fabretti F, Benzing T; ''Caenorhabditis elegans, a model organism for kidney research: from cilia to mechanosensation and longevity.''; Curr Opin Nephrol Hypertens, 2011 PubMed Europe PMC Scholia
  4. Winyard P, Jenkins D; ''Putative roles of cilia in polycystic kidney disease.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  5. Barr MM, DeModena J, Braun D, Nguyen CQ, Hall DH, Sternberg PW; ''The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.''; Curr Biol, 2001 PubMed Europe PMC Scholia
  6. Hu J, Bae YK, Knobel KM, Barr MM; ''Casein kinase II and calcineurin modulate TRPP function and ciliary localization.''; Mol Biol Cell, 2006 PubMed Europe PMC Scholia
  7. Barr MM, Sternberg PW; ''A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.''; Nature, 1999 PubMed Europe PMC Scholia
  8. Hu J, Wittekind SG, Barr MM; ''STAM and Hrs down-regulate ciliary TRP receptors.''; Mol Biol Cell, 2007 PubMed Europe PMC Scholia
  9. Bae YK, Qin H, Knobel KM, Hu J, Rosenbaum JL, Barr MM; ''General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.''; Development, 2006 PubMed Europe PMC Scholia
  10. Hu J, Barr MM; ''ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.''; Mol Biol Cell, 2005 PubMed Europe PMC Scholia
  11. Qin H, Rosenbaum JL, Barr MM; ''An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons.''; Curr Biol, 2001 PubMed Europe PMC Scholia
  12. Bae YK, Kim E, L'hernault SW, Barr MM; ''The CIL-1 PI 5-phosphatase localizes TRP Polycystins to cilia and activates sperm in C. elegans.''; Curr Biol, 2009 PubMed Europe PMC Scholia
  13. Miller RM, Portman DS; ''A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5.''; Dis Model Mech, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135396view15:43, 3 September 2024EgonwConverted to use Ensembl identifiers
134253view04:54, 18 July 2024EgonwRemoved template comments
123896view11:30, 25 August 2022Finterlyfixed special shape
118412view14:16, 27 May 2021RaatsSfixed unconnected lines
78461view10:27, 7 January 2015MaintBotadded missing graphIds
73984view21:50, 13 March 2014Kyookreformatted colors and node shapes
73983view21:49, 13 March 2014KyookPeriodical save, work in progress
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73763view00:11, 22 February 2014MaintBotFixing empty labels on datanodes
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External references

DataNodes

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NameTypeDatabase referenceComment
ASB-1GeneProductF35G12.10 (WormBase) ASB-1 and ASG-2 localize to male-specific sensory cilia as well as mitochondria.
ASG-1GeneProductK07A12.3 (WormBase) ASB-1 and ASG-2 localize to male-specific sensory cilia as well as mitochondria.
ATP-2GeneProductC34E10.6 (WormBase)
  • ATP-2 is identified as one candidate that physically interacts with the PLAT domain of LOV-1
  • ATP-2 amd other ATP synthase components were found to localize to the cilia of male-specific sensory neurons.
  • ATP-2::GFP clearly colocalizes with PKD-2::DsRed2 in CEM cilia.
CHE-11GeneProductC27A7.4 (WormBase)
CIL-1GeneProductC50C3.7 (WormBase)
CWP-5GeneProductF48C11.2 (WormBase)
DAF-10GeneProductF23B2.4 (WormBase)
HGSRS-1/HrsGeneProductC07G1.5 (WormBase)
KAP-1GeneProductF08F8.3 (WormBase) IFT Complex A poly peptides , DAF-10 and CHE-11 move and that motility is at the same rate as IFT Complex B polypeptides, OSM-1, OSM-5 and OSM-6, and KAP (a subunit of the kinesin motor).
LOV-1/PC-1GeneProductZK945.9 (WormBase)
  • LOV-1 localized to cilia by CIL-1
  • LOV-1 is expressed in male specific sensory neurons...with basodendritic subcellular localization in cell body and sensory endings
  • lov-1 and atp-2 are coexpressed in the tail ray B neurons and HOB hook neuron...as well as the male-specific CEM head neurons.
  • lov-1 is exclusively expressed in three categories of adult male sensory neurons: the rays, the hook, and the head CEMs
LOV-1GeneProductZK945.9 (WormBase) LOV-1 localizes to intracellular membranes
OSM-1GeneProductT27B1.1 (WormBase)
OSM-5GeneProductY41G9A.1 (WormBase) OSM-5 localizes to cilia through its TPR repeats through intraflagellar transport
OSM-6GeneProductR31.3 (WormBase)
PI(3,5)P2Metabolite
PI3PMetabolite
PKD-2/PC-2GeneProductY73F8A.1 (WormBase)
  • PKD-2 localized to cilia by CIL-1
  • LOV-1 is expressed in male specific sensory neurons...with basodendritic subcellular localization in cell body and sensory endings
  • PKD-2 GFP accumulates in a ring around the ciliary transition zones
  • Functional localization of PKD-2 is in the ciliary plasma membrane and in intracellular membrane
  • PKD-2 protein is hghly enriched in sensory cilia that are directly exposed to the environment
PKD-2GeneProductY73F8A.1 (WormBase)
  • PKD-2 localizes to intracellular membranes
  • functional localization of PKD-2 is in the ciliary plasma membrane
STAM-1/STAMGeneProductC34G6.7 (WormBase)
  • STAM-1A specifically associates with the LOV-1 C-tail
  • stam-1 and pkd-2 are clearly coexpressed in male-specific ciliated CEM, ray B-type(RnB), and hook HOB sensory neurons
  • STAM-1A::GFP labels puncta and accumulates at ciliary bases, but is obviously excluded from the cilium proper of CEM, RnB and HOB neurons
  • STAM-1A co-localizes at the ciliary base with LOV-1 and PKD-2
Unknown

Annotated Interactions

No annotated interactions

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