AGE/RAGE pathway (Homo sapiens)

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MAPK9PSMAD3PMAPK3PSMAD3PSTAT5BPIKBKBPAGERPNeuriteAGE/RAGE Signaling PathwayCalcification of smooth muscle cellsAGERPCDC42GTPRAC1GTPGgRHOAGTPCASP3IRS1PRKCAPMYD88IRAK4MSNPTIRAPROCK1PHRASGTPSRCPMAPK1PFOXO1SP1dePNFKB1RELAPPAKT1MAPK14dePPMAPK8PPFOXO4JAK2PSTAT1STAT3PCHUKPPCASP8NFKBIAUbPNFKB1RELAPPSMAD2PSMAD2PTubular epithelium myofibroblast transitionDIAPH1PLCPLA2G4APNa+ K+ ATPaseNeutrophilRearrangement of the actin cytoskeletonAutophagy in vascular smooth muscle cellsDissolution of gap junctions in human hepatoma cellsCell proliferationATF2JUNPPFibroblastsCASP9Retinal pericytesOsteoblastsINS-1 cellsNONeuroblastoma cellsIncrease in monolayer permeabilityRenal cellular hypertrophyMitogeneis in NRK-49F cellsMAP2K1PRAF1PALPLMonocyte adhesion to retinal endothelial cellsNCF1PSTAT5APSP1NOXApoptosis inFOXO1FOXO4Osteogenicdifferentiationof VSMCsRenal proximal tubular cellsNOS2NOS3Endothelial cellDegradationDissociationH2O2MitochondrialPRKCBPRKCZProteinDissociation of PPIReceptorProteinTransportLeads toInduced catalysisProtein-protein interaction (PPI)LEGENDPhosphorylationNucleusCytoplasmCYNUEnzymeEnzyme complex or specific component unknownCYNUCYNUCYNUCYNUCYNUCYNUCMLCELAGE-modified albuminPentosidineLigandSmall moleculesEnzymeProteins activated (identified by assays)MTMitochondriaCYMTApoptosis inPodocytesFibroblastsCYCSCYCSSOD1burstTGF-betaindependentDephosphorylationInhibition of proliferation and migration ofbone marrow mesenchymal stem cellsT-cellsEndothelial cell permeabilityPIP2DAGCa2+Arachidonic acidROSoutgrowthpermeabilitytransitiondysfunctionsGlyc-FBSPhosphorylated stateUbUbiquitinated stateGgGeranylgeranylated statedePDephosphrylated stateRegulation ofcytoskeletonCML-CollagenFormation of F-actin stress fibersSHC1PEGFRPDDOSTInternalizationAGE removalandAGEsMSR1AGEsINSINSRHIF1AHIF1ACYNUInhibition oftubulogenesis ofproximal tubule cellsEZRdePPPlacenta andgestational membranesProstaglandin F2alphaProstaglandin E2Released fromChondrocytesLGALS3AGEsincreasedPRKCDPInhibition ofMicroglial cellsMMP2MMP14MMP13MMP9MMP7


Description

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Ontology Terms

 

Bibliography

  1. Lin FL, Chang CI, Chuang KP, Wang CY, Liu HJ; ''Advanced glycation end products down-regulate gap junctions in human hepatoma SKHep 1 cells via the activation of Src-dependent ERK1/2 and JNK/SAPK/AP1 signaling pathways.''; J Agric Food Chem, 2010 PubMed Europe PMC Scholia
  2. Alikhani Z, Alikhani M, Boyd CM, Nagao K, Trackman PC, Graves DT; ''Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  3. Li JH, Wang W, Huang XR, Oldfield M, Schmidt AM, Cooper ME, Lan HY; ''Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway.''; Am J Pathol, 2004 PubMed Europe PMC Scholia
  4. Mamputu JC, Renier G; ''Advanced glycation end-products increase monocyte adhesion to retinal endothelial cells through vascular endothelial growth factor-induced ICAM-1 expression: inhibitory effect of antioxidants.''; J Leukoc Biol, 2004 PubMed Europe PMC Scholia
  5. Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, Hibino T, Kataoka K, Huh NH; ''TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.''; PLoS One, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126372view17:52, 25 April 2023EgonwLicense is CCZero (more specific)
120674view01:34, 23 December 2021EweitzStandardize font, weight, case
105867view23:29, 15 August 2019KhanspersModified description
105429view04:30, 8 August 2019KhanspersModified description
96980view18:21, 24 April 2018AlexanderPicoReverted to version '04:26, 6 October 2016' by AlexanderPico
96974view15:49, 24 April 2018WpblockedModified title
89798view11:26, 6 October 2016Mkutmonfixed special character in description
78487view10:28, 7 January 2015MaintBotadded missing graphIds
71701view19:53, 17 October 2013MaintBotremoved data source from nodes without identifier
67034view09:56, 26 June 2013Christine ChichesterOntology Term : 'receptor for advanced glycation end-products signaling pathway' added !
63150view20:17, 8 May 2013MaintBotUpdating GPML version
53381view04:53, 6 November 2012NetPathModified description
53109view01:19, 30 October 2012MaintBotModified categories
52521view10:22, 15 October 2012NetPathModified description
52516view10:14, 15 October 2012NetPathNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AGE-modified albuminProtein
AGERProtein177 (Entrez Gene)
AGEsProtein
AKT1Protein207 (Entrez Gene)
ALPLProtein249 (Entrez Gene)
ATF2Protein1386 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CASP8Protein841 (Entrez Gene)
CASP9Protein842 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CELProtein
CHUKProtein1147 (Entrez Gene)
CML-CollagenProtein
CMLProtein
CYCSProtein54205 (Entrez Gene)
DDOSTProtein1650 (Entrez Gene)
DIAPH1Protein1729 (Entrez Gene)
EGFRProtein1956 (Entrez Gene)
EZRProtein7430 (Entrez Gene)
FOXO1Protein2308 (Entrez Gene)
FOXO4Protein4303 (Entrez Gene)
Glyc-FBSProtein
H2O2Protein
HIF1AProtein3091 (Entrez Gene)
HRASProtein3625 (Entrez Gene)
IKBKBProtein3551 (Entrez Gene)
INSProtein3630 (Entrez Gene)
INSRProtein3643 (Entrez Gene)
IRAK4Protein51135 (Entrez Gene)
IRS1Protein3667 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
LGALS3Protein3958 (Entrez Gene)
LigandProtein
MAP2K1Protein5604 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP13Protein4322 (Entrez Gene)
MMP14Protein4323 (Entrez Gene)
MMP2Protein4313 (Entrez Gene)
MMP7Protein4316 (Entrez Gene)
MMP9Protein4318 (Entrez Gene)
MSNProtein4478 (Entrez Gene)
MSR1Protein4481 (Entrez Gene)
MYD88Protein4615 (Entrez Gene)
NCF1Protein653361 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NOProtein
NOS2Protein4843 (Entrez Gene)
NOS3Protein4846 (Entrez Gene)
NOXProtein
Na+ K+ ATPaseProtein
PLA2G4AProtein5321 (Entrez Gene)
PLCProtein
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCZProtein5590 (Entrez Gene)
PentosidineProtein
ProteinGeneProduct
RAC1Protein5879 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RHOAProtein387 (Entrez Gene)
ROCK1Protein6093 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SMAD2Protein4087 (Entrez Gene)
SMAD3Protein4088 (Entrez Gene)
SOD1Protein6647 (Entrez Gene)
SP1Protein6667 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
TIRAPProtein114609 (Entrez Gene)

Annotated Interactions

No annotated interactions

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