Angiogenesis overview (Homo sapiens)
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Ca2+ release
Ca2+
survival
eloC
lamellopodia and filopodia
GF
Stem Cell
TK
Integrins
angiogenesis
MT-MMP
migration
breakdown of extracellular
tissue like collagen
ROS
migration
survival
Proteosome
migration
proliferation
permeability
transcription of angiogenesis-related genes
ROBO1
DOK2
AKT1
NADPH oxidase 2
RAF1
MAP3K7
MAP2K1
MAP2K1
PLXND1
NOX4
Dia1
FAK
PIK3CD
PLCG1
OH
NO
ATF2
ELK1
IP3
FGF1
PRKCA
SHC1
ANGPT1
SOS1
MMP9
PTPN11
SLIT2
MMP2
SRC
CRK
TIMP4
PI3K
MMP14
MAPK11
PIP3
PAK1
WASP
IP2
HIF2-alpha
ROBO4
RAF1
PLD
PIP2
NOS3
TEK
KDR
PDPK1
MMP12
TIMP2
MAP2K6
Ras
SHB
CRK
IQGAP1
PHD
FRS2
ERK 1/2 MAPK
PIP2
ROBO1
PLA2G1B
CDC42
GRB14
AKT1
MAPK1
NRP1
MTOR
Ras GAP
DAG1
STAT5
FAK
PRKCA
MAPK8
BAD
MMPs
GRB2
BMX
SEMA3A
Thrombin
NCK1
GRB2
APC
CDC42
RAS
SEMA4A
PLC-gamma
RAC1
urokinase-plasminogen activator
hypoxia
MAPK14
PTPN11
ROBO4
Ras
VEGFA
DAG1
PXN
VHL
FGFR1
MAP2K4
STAT3
HIF2-alpha
HIF2-alpha
OH
pUb
eloB
GRB2
SOS1
GRB7
SLIT2
Stem Cell
Stem Cell
lamellopodia and filopodia
SLIT2
Description
Overview of processes involved in the development of angiogenesis in humans.
Comments
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History
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Compare
Revision
Action
Time
User
Comment
126081
view
09:00, 1 April 2023
Egonw
Removed unclear "GF" comment
126080
view
08:50, 1 April 2023
Egonw
Added a few datanode types (guessed a few, because no IDs were given)
110975
view
14:21, 25 June 2020
L Dupuis
Connected lines
106214
view
12:11, 16 August 2019
MaintBot
HMDB identifier normalization
85555
view
08:32, 29 May 2016
Egonw
Replaced a mim-conversion with Arrow.
71385
view
18:41, 17 October 2013
MaintBot
Automated update of data sources
71268
view
21:58, 16 October 2013
MaintBot
Automated update of data sources
69001
view
17:45, 8 July 2013
MaintBot
Updated to 2013 gpml schema
59192
view
19:07, 22 February 2013
MaintBot
Updated Ensembl and UniProt data source
58505
view
19:00, 14 February 2013
MaintBot
Modified title
44954
view
12:37, 6 October 2011
MartijnVanIersel
Ontology Term : 'growth factor signaling pathway' added !
44820
view
13:30, 5 October 2011
Susan
Modified description
44464
view
18:42, 14 September 2011
MaintBot
Modified categories
44462
view
14:33, 14 September 2011
Helix
angiogenesis overview
44393
view
10:35, 8 September 2011
Helix
angiogenesis overviuew
44392
view
10:26, 8 September 2011
Helix
Periodical save, work in progress
44389
view
10:15, 8 September 2011
Helix
Periodical save, work in progress
43912
view
12:37, 16 August 2011
Helix
angiogensisi overview
43911
view
12:29, 16 August 2011
Helix
Periodical save, work in progress
43909
view
12:19, 16 August 2011
Helix
Periodical save, work in progress
43908
view
11:54, 16 August 2011
Helix
Periodical save, work in progress
43907
view
11:43, 16 August 2011
Helix
Periodical save, work in progress
43906
view
11:31, 16 August 2011
Helix
angiogenesis overview
43905
view
11:11, 16 August 2011
Helix
Periodical save, work in progress
43902
view
11:48, 15 August 2011
Helix
angiogenesis overview
43901
view
11:46, 15 August 2011
Helix
Periodical save, work in progress
43900
view
11:36, 15 August 2011
Helix
Periodical save, work in progress
43899
view
11:26, 15 August 2011
Helix
Periodical save, work in progress
43898
view
11:15, 15 August 2011
Helix
Periodical save, work in progress
43896
view
11:04, 15 August 2011
Helix
angiogenesis overview
43605
view
09:00, 7 July 2011
Helix
angiopgenesis overview
43604
view
08:57, 7 July 2011
Helix
Periodical save, work in progress
43603
view
08:46, 7 July 2011
Helix
Periodical save, work in progress
43602
view
08:36, 7 July 2011
Helix
Periodical save, work in progress
43596
view
09:28, 6 July 2011
Helix
angiogenesis overview
43146
view
13:05, 3 June 2011
Helix
angiogenesis overview
43145
view
12:58, 3 June 2011
Helix
Periodical save, work in progress
43144
view
12:48, 3 June 2011
Helix
Periodical save, work in progress
43143
view
12:37, 3 June 2011
Helix
Periodical save, work in progress
43142
view
12:27, 3 June 2011
Helix
Periodical save, work in progress
43141
view
12:17, 3 June 2011
Helix
Periodical save, work in progress
43140
view
11:38, 3 June 2011
Helix
Periodical save, work in progress
43139
view
11:28, 3 June 2011
Helix
Periodical save, work in progress
43138
view
11:17, 3 June 2011
Helix
Periodical save, work in progress
43137
view
11:07, 3 June 2011
Helix
Periodical save, work in progress
43136
view
10:43, 3 June 2011
Helix
Periodical save, work in progress
43135
view
10:40, 3 June 2011
Helix
angiogenesis overview
43134
view
10:33, 3 June 2011
Helix
Periodical save, work in progress
43133
view
10:23, 3 June 2011
Helix
Periodical save, work in progress
43132
view
10:13, 3 June 2011
Helix
Periodical save, work in progress
External references
DataNodes
View all...
Name
Type
Database reference
Comment
AKT1
GeneProduct
ENSG00000142208 (Ensembl Human)
ANGPT1
GeneProduct
ENSG00000154188 (Ensembl Human)
APC
GeneProduct
ENSG00000134982 (Ensembl Human)
ATF2
GeneProduct
ENSG00000115966 (Ensembl Human)
BAD
GeneProduct
ENSG00000002330 (Ensembl Human)
BMX
GeneProduct
ENSG00000102010 (Ensembl Human)
CDC42
GeneProduct
ENSG00000070831 (Ensembl Human)
CRK
GeneProduct
ENSG00000167193 (Ensembl Human)
DAG1
GeneProduct
ENSG00000173402 (Ensembl Human)
DOK2
GeneProduct
ENSG00000147443 (Ensembl Human)
Dia1
Protein
NP_031884.1 (RefSeq)
ELK1
GeneProduct
ENSG00000126767 (Ensembl Human)
ERK 1/2 MAPK
Protein
FAK
Protein
FAK
Protein
Q14289 (Uniprot/TrEMBL)
FGF1
GeneProduct
ENSG00000113578 (Ensembl Human)
FGFR1
GeneProduct
ENSG00000077782 (Ensembl Human)
FRS2
GeneProduct
ENSG00000166225 (Ensembl Human)
GRB14
GeneProduct
ENSG00000115290 (Ensembl Human)
GRB2
GeneProduct
ENSG00000177885 (Ensembl Human)
GRB7
GeneProduct
ENSG00000141738 (Ensembl Human)
HIF2-alpha
Protein
IP2
Protein
IP3
IQGAP1
GeneProduct
ENSG00000140575 (Ensembl Human)
KDR
GeneProduct
ENSG00000128052 (Ensembl Human)
MAP2K1
GeneProduct
ENSG00000169032 (Ensembl Human)
MAP2K4
GeneProduct
ENSG00000065559 (Ensembl Human)
MAP2K6
GeneProduct
ENSG00000108984 (Ensembl Human)
MAP3K7
GeneProduct
ENSG00000135341 (Ensembl Human)
MAPK11
GeneProduct
ENSG00000185386 (Ensembl Human)
MAPK14
GeneProduct
ENSG00000112062 (Ensembl Human)
p38 MAPK
MAPK1
GeneProduct
ENSG00000100030 (Ensembl Human)
MAPK8
GeneProduct
ENSG00000107643 (Ensembl Human)
MMP12
Protein
MMP14
GeneProduct
ENSG00000157227 (Ensembl Human)
MMP2
GeneProduct
ENSG00000087245 (Ensembl Human)
MMP9
GeneProduct
ENSG00000100985 (Ensembl Human)
MMPs
GeneProduct
ENSG00000087245 (Ensembl Human)
MTOR
GeneProduct
ENSG00000198793 (Ensembl Human)
NADPH oxidase 2
Protein
NCK1
GeneProduct
ENSG00000158092 (Ensembl Human)
NO
NOS3
GeneProduct
ENSG00000164867 (Ensembl Human)
NOX4
GeneProduct
ENSG00000086991 (Ensembl Human)
NRP1
GeneProduct
ENSG00000099250 (Ensembl Human)
OH
PAK1
GeneProduct
5058 (Entrez Gene)
PDPK1
GeneProduct
ENSG00000140992 (Ensembl Human)
PHD
Protein
PI3K
Protein
PIK3CD
GeneProduct
ENSG00000171608 (Ensembl Human)
PIP2
Protein
PIP2
Metabolite
HMDB10032 (HMDB)
PIP3
Protein
PLA2G1B
GeneProduct
ENSG00000170890 (Ensembl Human)
PLC-gamma
GeneProduct
ENSG00000124181 (Ensembl Human)
PLCG1
GeneProduct
ENSG00000124181 (Ensembl Human)
PLD
Protein
PLXND1
GeneProduct
ENSG00000004399 (Ensembl Human)
PRKCA
GeneProduct
ENSG00000154229 (Ensembl Human)
PTPN11
GeneProduct
ENSG00000179295 (Ensembl Human)
PXN
GeneProduct
ENSG00000089159 (Ensembl Human)
RAC1
GeneProduct
ENSG00000136238 (Ensembl Human)
RAF1
GeneProduct
ENSG00000132155 (Ensembl Human)
RAS
GeneProduct
ENSG00000133703 (Ensembl Human)
ROBO1
GeneProduct
ENSG00000169855 (Ensembl Human)
ROBO4
GeneProduct
ENSG00000154133 (Ensembl Human)
Ras
Protein
Ras
Protein
ENSG00000133703 (Ensembl Human)
Ras GAP
Protein
SEMA3A
GeneProduct
ENSG00000075213 (Ensembl Human)
SEMA4A
GeneProduct
ENSG00000196189 (Ensembl Human)
SHB
GeneProduct
ENSG00000107338 (Ensembl Human)
SHC1
GeneProduct
ENSG00000160691 (Ensembl Human)
SLIT2
GeneProduct
ENSG00000145147 (Ensembl Human)
SOS1
GeneProduct
ENSG00000115904 (Ensembl Human)
SRC
GeneProduct
ENSG00000197122 (Ensembl Human)
STAT3
Protein
STAT5
Protein
TEK
GeneProduct
ENSG00000120156 (Ensembl Human)
TIMP2
GeneProduct
ENSG00000035862 (Ensembl Human)
TIMP4
GeneProduct
ENSG00000157150 (Ensembl Human)
Thrombin
Protein
176930 (OMIM)
VEGFA
GeneProduct
ENSG00000112715 (Ensembl Human)
VHL
GeneProduct
ENSG00000134086 (Ensembl Human)
WASP
Protein
P42768 (Uniprot/TrEMBL)
hypoxia
pUb
urokinase-plasminogen activator
Protein
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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External references
DataNodes
Annotated Interactions
No annotated interactions