Proteasome degradation (Canis familiaris)

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Activators of20S ComplexBeta subunitsDeubiquitinates proteinsProteins to be DegradedAMP Ubiquitin/E1 ComplexUbiquitin/ProteinAlpha subunitsOxidatively DamagedCytosolic ProteinsDegrades only PeptidesE3/ProteinLid subunitsProteasome 26 S(PA700) (ATP dependent)Unfolds and DegradesIntact ProteinsUbiquitin/E2 ComplexProteasome 20SCatalytic Core (p45)Presentation by MHC class 1p45 ATPase SubunitPSMB3PSMD10HLA-BPSMC6UCHL1PSMA6PSMA4PSMD2PSMD11HIST1H2ABIFNGUBBHLA-JPSMB7NEDD4PSMD5RPN1PSMA2HLA-CLOC489372HLA-GPSMD1PSMD7PSMB10PSMC2PSME3PSME2PSMB6UCHL3PSMD13UBE2D2PSMA5UBE2D1PSMC1PSMB1UBA7HLA-HPSMD4PSMD9RPN2UbiquitinPSMD6ATPPSMD8PSMB8PSMC3PSMA7PSMC5PSMA3PSMB2PSMA1DLA-79UBCPSMB5PSMB4UBE2BHLA-APSMD12PSME1PSMD3PSMC5UBA1LOC478493PSMC4HLA-EPSMB9UBE2D3


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP183(r29614) with a 74% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
117059view14:22, 16 May 2021EweitzModified title
87612view08:54, 25 July 2016LindarieswijkOntology Term : 'ubiquitin, ubiquitin-like/proteasome degradation pathway' added !
71476view19:18, 17 October 2013MaintBotAutomated update of data sources
68569view22:55, 5 July 2013MaintBotUpdated to 2013 gpml schema
62724view03:18, 2 May 2013MaintBotUpdated UniProt data source
58848view23:34, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40727view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
34006view18:40, 9 December 2009MaintBotAutomatic update of empty xrefs
32272view13:05, 15 August 2009MaintBotFixed text labels
31806view12:20, 14 August 2009MaintBotFixed group labels
31300view20:10, 13 August 2009MaintBotFixed text labels
30765view23:14, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite
DLA-79GeneProduct483594 (Entrez Gene)
HIST1H2ABGeneProduct
HLA-AGeneProduct
HLA-BGeneProduct
HLA-CGeneProduct
HLA-EGeneProduct
HLA-GGeneProduct
HLA-HGeneProduct
HLA-JGeneProduct
IFNGGeneProduct403801 (Entrez Gene)
LOC478493GeneProduct478493 (Entrez Gene)
LOC489372GeneProduct489372 (Entrez Gene)
NEDD4GeneProduct608738 (Entrez Gene)
PSMA1GeneProduct476867 (Entrez Gene)
PSMA2GeneProduct475870 (Entrez Gene)
PSMA3GeneProduct480338 (Entrez Gene)
PSMA4GeneProduct475132 (Entrez Gene)
PSMA5GeneProduct490123 (Entrez Gene)
PSMA6GeneProduct480290 (Entrez Gene)
PSMA7GeneProduct404305 (Entrez Gene)
PSMB10GeneProduct489749 (Entrez Gene)
PSMB1GeneProduct475040 (Entrez Gene)
PSMB2GeneProduct475338 (Entrez Gene)
PSMB3GeneProduct480537 (Entrez Gene)
PSMB4GeneProduct475848 (Entrez Gene)
PSMB5GeneProduct480246 (Entrez Gene)
PSMB6GeneProduct607466 (Entrez Gene) U13393
PSMB7GeneProduct
PSMB8GeneProduct474865 (Entrez Gene)
PSMB9GeneProduct474867 (Entrez Gene)
PSMC1GeneProduct478703 (Entrez Gene)
PSMC2GeneProduct475896 (Entrez Gene)
PSMC3GeneProduct475980 (Entrez Gene)
PSMC4GeneProduct476459 (Entrez Gene) PRS6 HUMAN
PSMC5GeneProduct480478 (Entrez Gene) PRS6 HUMAN
PSMC6GeneProduct478522 (Entrez Gene)
PSMD1GeneProduct
PSMD10GeneProduct481014 (Entrez Gene)
PSMD11GeneProduct480610 (Entrez Gene)
PSMD12GeneProduct480465 (Entrez Gene)
PSMD13GeneProduct475934 (Entrez Gene)
PSMD2GeneProduct478654 (Entrez Gene)
PSMD3GeneProduct491018 (Entrez Gene)
PSMD4GeneProduct100192385 (Entrez Gene)
PSMD5GeneProduct474703 (Entrez Gene)
PSMD6GeneProduct484700 (Entrez Gene)
PSMD7GeneProduct479671 (Entrez Gene)
PSMD8GeneProduct476470 (Entrez Gene)
PSMD9GeneProduct477467 (Entrez Gene)
PSME1GeneProduct480256 (Entrez Gene)
PSME2GeneProduct480258 (Entrez Gene)
PSME3GeneProduct480512 (Entrez Gene)
RPN1GeneProduct476516 (Entrez Gene)
RPN2GeneProduct477223 (Entrez Gene)
UBA1GeneProduct480896 (Entrez Gene)
UBA7GeneProduct608118 (Entrez Gene)
UBBGeneProduct479513 (Entrez Gene)
UBCGeneProduct610457 (Entrez Gene)
UBE2BGeneProduct474683 (Entrez Gene)
UBE2D1GeneProduct608578 (Entrez Gene)
UBE2D2GeneProduct612742 (Entrez Gene)
UBE2D3GeneProduct
UCHL1GeneProductENSCAFG00000015878 (Ensembl)
UCHL3GeneProduct476947 (Entrez Gene)
UbiquitinProtein

Annotated Interactions

No annotated interactions
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