NAD biosynthesis II from tryptophan (Homo sapiens)

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spontaneousCarbon dioxideL-Glutamic acidPyrophosphateTDO2N'-FormylkynurenineNADPPhosphoribosylpyrophosphateAdenosinetriphosphateQuinolinic acidAFMIDL-AlanineWaterAdenosinemonophosphateL-KynurenineNMNAT1NADPHAdenosinetriphosphate2-Amino-3-carboxymuconicacid semialdehydeL-3-HydroxykynureninePyrophosphateL-GlutamineHydrogen IonOxygenNicotinic acidadenine dinucleotideNicotinic acidmononucleotideNADSYN1Formic acidL-TryptophanWaterKYNUWaterQPRTNADHAAOKMOpyrophosphate3-Hydroxyanthranilic acidHydrogen IonWaterHydrogen IonHydrogen IonHydrogen IonHydrogen IonOxygenHydrogen IonWaterHydrogen IonHydrogen IonHydrogen IonOxygenHydrogen IonHydrogen Ion


Description

This is a general pathway for NAD biosynthesis in eukaryotes, where tryptophan is eventually converted into NAD. Though through recent studies it seems that NAD biosynthesis through tryptophan also occurs in some prokaryotes.

Comments

GenMAPP notes 
http://biocyc.org/META/new-image?type=PATHWAY&object=NADSYN-PWY&detail-level=3&ENZORG=TAX-9606

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
134903view01:13, 29 July 2024EweitzModified title
117161view09:47, 18 May 2021EweitzModified title
108352view09:25, 11 December 2019L DupuisConnected unconnected lines
106715view13:15, 17 September 2019MaintBotHMDB identifier normalization
102307view21:04, 17 December 2018KhanspersModified description
102306view21:01, 17 December 2018Khanspersremoved GenMAPP comment
70025view01:53, 12 July 2013AlexanderPicoModified title
69051view17:55, 8 July 2013EgonwMarked 'pyrophosphate' with a CAS number as metabolite.
62867view10:33, 3 May 2013CizarModified description
62270view22:24, 26 April 2013AlexanderPicoOntology Term : 'NAD biosynthetic pathway' added !
62269view22:24, 26 April 2013AlexanderPicoModified categories
61951view07:29, 22 April 2013CizarGrouped metabolites and aligned them
61804view10:55, 19 April 2013CizarModified description
61794view09:50, 19 April 2013CizarNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-Amino-3-carboxymuconic acid semialdehydeMetaboliteHMDB01330 (HMDB)
3-Hydroxyanthranilic acidMetaboliteHMDB01476 (HMDB)
AFMIDGeneProductENSG00000183077 (Ensembl)
Adenosine monophosphateMetaboliteHMDB00045 (HMDB)
Adenosine triphosphateMetaboliteHMDB00538 (HMDB)
Carbon dioxideMetaboliteHMDB01967 (HMDB)
Formic acidMetaboliteHMDB00142 (HMDB)
HAAOGeneProductENSG00000162882 (Ensembl)
Hydrogen IonMetaboliteHMDB59597 (HMDB)
KMOGeneProductENSG00000117009 (Ensembl)
KYNUGeneProductENSG00000115919 (Ensembl)
L-3-HydroxykynurenineMetaboliteHMDB11631 (HMDB)
L-AlanineMetaboliteHMDB00161 (HMDB)
L-Glutamic acidMetaboliteHMDB00148 (HMDB)
L-GlutamineMetaboliteHMDB00641 (HMDB)
L-KynurenineMetaboliteHMDB00684 (HMDB)
L-TryptophanMetaboliteHMDB00929 (HMDB)
N'-FormylkynurenineMetaboliteHMDB01200 (HMDB)
NADMetaboliteHMDB00902 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
NADPMetaboliteHMDB00217 (HMDB)
NADSYN1GeneProductENSG00000172890 (Ensembl)
NMNAT1GeneProductENSG00000173614 (Ensembl)
Nicotinic acid adenine dinucleotideMetaboliteHMDB01179 (HMDB)
Nicotinic acid mononucleotideMetaboliteHMDB01132 (HMDB)
OxygenMetaboliteHMDB01377 (HMDB)
Phosphoribosyl pyrophosphateMetaboliteHMDB00280 (HMDB)
PyrophosphateMetaboliteHMDB00250 (HMDB)
QPRTGeneProductENSG00000103485 (Ensembl)
Quinolinic acidMetaboliteHMDB00232 (HMDB)
TDO2GeneProductENSG00000151790 (Ensembl)
WaterMetaboliteHMDB02111 (HMDB)
pyrophosphate2466-09-3 (CAS)

Annotated Interactions

No annotated interactions
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