G13 signaling pathway (Pan troglodytes)

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1Contraction & Actin-MyosinInteraction, Focal AdhesionStress Fiber ContractionActivated Rho AActin PolymerizationCytokinesisMembrane RufflingGActin Polymerizationilopodia FormationActin ReorganizationCell-Cell AdhesionDisassembly of ActinStress Fiber DisappearanceAnti-Apoptotic13PKN1PIK3CBWASLRHPN2MAPK10PIK3CDMYL1PPP1CBDIAPH1WASROCK1IQGAP1GNA13RPS6KB1PAK3MYBPHCFL1CALM1PFN1PIK3CALIMK1ROCK2SH3RF1IQGAP2ARHGEF1ARHGDIGRTKNPIP4K2ATNK2PIK3R2ARHGDIBRAC1CDC42CFL2MAP3K4RHOAp140 Sra-1CIT


Description

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP524(r21780) with a 73% conversion rate.

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Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117394view10:34, 21 May 2021EweitzModified title
95756view14:07, 19 January 2018MkutmonHomology conversion update
72020view12:40, 24 October 2013Mkutmonfixed unconnected lines
71676view19:41, 17 October 2013MaintBotAutomated update of data sources
69269view18:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67279view10:30, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
62741view03:34, 2 May 2013MaintBotUpdated UniProt data source
41577view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35419view10:42, 12 February 2010ThomasModified description
35418view10:39, 12 February 2010Thomasremoved braces, fixed labels, added literature
34305view22:06, 9 December 2009MaintBotAutomatic update of empty xrefs
33595view09:55, 1 December 2009MaintBotRemoved group label
32477view17:40, 15 August 2009MaintBotFixed text labels
31615view22:16, 13 August 2009MaintBotFixed text labels
30514view21:47, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARHGDIBGeneProduct742002 (Entrez Gene)
ARHGDIGGeneProduct749799 (Entrez Gene)
ARHGEF1GeneProduct
CALM1GeneProduct738819 (Entrez Gene)
CDC42GeneProduct456609 (Entrez Gene)
CFL1GeneProduct745772 (Entrez Gene)
CFL2GeneProduct452853 (Entrez Gene)
CITGeneProduct452298 (Entrez Gene)
DIAPH1GeneProduct
GNA13GeneProduct454827 (Entrez Gene)
IQGAP1GeneProduct467762 (Entrez Gene)
IQGAP2GeneProduct461801 (Entrez Gene)
LIMK1GeneProduct463466 (Entrez Gene)
MAP3K4GeneProduct
MAPK10GeneProduct461358 (Entrez Gene)
MYBPHGeneProduct457639 (Entrez Gene)
MYL1GeneProduct459915 (Entrez Gene)
PAK3GeneProduct450118 (Entrez Gene)
PFN1GeneProduct
PIK3CAGeneProduct460858 (Entrez Gene)
PIK3CBGeneProduct471079 (Entrez Gene)
PIK3CDGeneProduct457922 (Entrez Gene) P42338
PIK3R2GeneProduct455855 (Entrez Gene)
PIP4K2AGeneProduct742458 (Entrez Gene)
PKN1GeneProduct455785 (Entrez Gene)
PPP1CBGeneProduct459118 (Entrez Gene)
RAC1GeneProduct
RHOAGeneProduct461014 (Entrez Gene)
RHPN2GeneProduct742833 (Entrez Gene)
ROCK1GeneProduct455326 (Entrez Gene) S69211
ROCK2GeneProduct470307 (Entrez Gene) BAA31594
RPS6KB1GeneProduct468426 (Entrez Gene) A41687
RTKNGeneProduct459334 (Entrez Gene)
SH3RF1GeneProduct461598 (Entrez Gene) Posh
TNK2GeneProductS33596
WASGeneProduct
WASLGeneProduct463688 (Entrez Gene)
p140 Sra-1GeneProduct

Annotated Interactions

No annotated interactions
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