Integrated cancer pathway (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed Europe PMC Scholia
2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
3. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T; ''MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.''; Gastroenterology, 2007 PubMed Europe PMC Scholia
4. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	137094	view	22:42, 27 February 2025	Khanspers	Modified description
	126414	view	20:17, 26 April 2023	Egonw	License is CCZero
	117762	view	13:24, 22 May 2021	Eweitz	Modified title
	106620	view	20:47, 12 September 2019	Khanspers	Modified description
	105629	view	05:02, 10 August 2019	Khanspers	Modified description
	103003	view	15:02, 31 January 2019	Marvin M2	Updated miRNA Ensembl IDs
	98351	view	05:22, 24 August 2018	Egonw	Updated the MIR21 identifier.
	96025	view	15:33, 15 February 2018	Mkutmon	Modified description
	82939	view	08:51, 14 November 2015	Egonw	Updated Ensembl identifiers.
	82938	view	08:31, 14 November 2015	Egonw	Fixed a small topy in a comment.
	82936	view	22:43, 13 November 2015	AlexanderPico	Modified title
	80447	view	06:15, 23 June 2015	Khanspers	Added mir29 targeting to PTEN
	80431	view	20:03, 22 June 2015	Khanspers	Added mir21 targeting of CDC25A
	80425	view	18:50, 22 June 2015	Khanspers	Added mi21 targeting, cleaned up layout, connected lines and added some xrefs
	71249	view	20:29, 16 October 2013	MaintBot	Automated update of data sources
	67398	view	10:56, 26 June 2013	Ddigles	Ontology Term : 'cancer pathway' added !
	63221	view	21:01, 8 May 2013	MaintBot	Updating gpml version
	59118	view	22:27, 21 February 2013	MaintBot	Updated Ensembl and UniProt data source
	44858	view	09:54, 6 October 2011	MartijnVanIersel	Ontology Term : 'cancer' added !
	44469	view	20:30, 14 September 2011	MaintBot	Added category
	42356	view	23:30, 19 March 2011	Saibrahi	Specify description
	42355	view	23:20, 19 March 2011	Saibrahi	Periodical save, work in progress
	42354	view	22:22, 19 March 2011	Saibrahi	Specify description
	42262	view	21:45, 11 March 2011	AlexanderPico	Connected BRCA1 to database
	42257	view	14:35, 11 March 2011	Saibrahi	Specify description
	42256	view	14:31, 11 March 2011	Saibrahi	Periodical save, work in progress
	41986	view	11:44, 4 March 2011	Saibrahi	Specify description
	41985	view	11:36, 4 March 2011	Saibrahi	Periodical save, work in progress
	41984	view	11:26, 4 March 2011	Saibrahi	Periodical save, work in progress
	41976	view	02:50, 4 March 2011	Saibrahi	Periodical save, work in progress
	41975	view	02:48, 4 March 2011	Saibrahi	Specify description
	41076	view	23:20, 1 March 2011	MaintBot	Removed redundant pathway information and comments
	40454	view	17:45, 1 March 2011	Saibrahi	Periodical save, work in progress
	40442	view	20:41, 25 February 2011	Saibrahi	Periodical save, work in progress
	40439	view	15:07, 25 February 2011	Saibrahi	Specify description
	40438	view	14:57, 25 February 2011	Saibrahi	Periodical save, work in progress
	40437	view	14:55, 25 February 2011	Saibrahi	Specify description
	40436	view	14:47, 25 February 2011	Saibrahi	Periodical save, work in progress
	40435	view	14:37, 25 February 2011	Saibrahi	Periodical save, work in progress
	40432	view	14:26, 25 February 2011	Saibrahi	Specify description
	40430	view	11:26, 25 February 2011	Saibrahi	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
AKT1_HUMAN	Protein	P31749 (Uniprot/TrEMBL)
ASK1	Protein
ATF1	Protein
ATM_HUMAN	Protein	Q13315 (Uniprot/TrEMBL)
ATR_HUMAN	Protein	Q13535 (Uniprot/TrEMBL)
BACH1	Protein
BAD_HUMAN	Protein	Q92934 (Uniprot/TrEMBL)
BARD1_HUMAN	Protein	Q99728 (Uniprot/TrEMBL)
BAX_HUMAN	Protein	Q07812 (Uniprot/TrEMBL)
BCL2_HUMAN	Protein	P10415 (Uniprot/TrEMBL)
BLM_HUMAN	Protein	P54132 (Uniprot/TrEMBL)
BRCA1_HUMAN	Protein	P38398 (Uniprot/TrEMBL)
CASP3_HUMAN	Protein	P42574 (Uniprot/TrEMBL)
CASP8_HUMAN	Protein	Q14790 (Uniprot/TrEMBL)
CASP9_HUMAN	Protein	P55211 (Uniprot/TrEMBL)
CDC25A	GeneProduct	ENSG00000164045 (Ensembl)
CDC25B	GeneProduct	ENSG00000101224 (Ensembl)
CDC2_HUMAN	Protein	P06493 (Uniprot/TrEMBL)	Oncogene
CDK2_HUMAN	Protein	P24941 (Uniprot/TrEMBL)
CDK4_HUMAN	Protein	P11802 (Uniprot/TrEMBL)
CHK1_HUMAN	Protein	O14757 (Uniprot/TrEMBL)
CHK2_HUMAN	Protein	O96017 (Uniprot/TrEMBL)	Phosphrylated
Cctlp	Protein
DNA-PK	Metabolite
E2F1_HUMAN	Protein	Q01094 (Uniprot/TrEMBL)
JAK1_HUMAN	Protein	P23458 (Uniprot/TrEMBL)
MDM2_HUMAN	Protein	Q00987 (Uniprot/TrEMBL)	Oncogene
MMP1_HUMAN	Protein	P03956 (Uniprot/TrEMBL)
MRE11_HUMAN	Protein	P49959 (Uniprot/TrEMBL)
MSH2_HUMAN	Protein	P43246 (Uniprot/TrEMBL)
MSH6_HUMAN	Protein	P52701 (Uniprot/TrEMBL)
MYC	Protein
NOXA1_HUMAN	Protein	Q86UR1 (Uniprot/TrEMBL)
OCT1	Protein
P53_HUMAN	Protein	P04637 (Uniprot/TrEMBL)
PLK1	GeneProduct	ENSG00000166851 (Ensembl)
PTEN_HUMAN	Protein	P60484 (Uniprot/TrEMBL)
PUMA	Protein
Q8NBS1_HUMAN	Protein	Q8NBS1 (Uniprot/TrEMBL)
RAD50_HUMAN	Protein	Q92878 (Uniprot/TrEMBL)
RB_HUMAN	Protein	P06400 (Uniprot/TrEMBL)
SMAD2_HUMAN	Protein	Q15796 (Uniprot/TrEMBL)	Tumor supressor
SMAD3_HUMAN	Protein	P84022 (Uniprot/TrEMBL)
STAT1_HUMAN	Protein	P42224 (Uniprot/TrEMBL)
Swi/SNF	Protein
p13K	Protein
p14	Protein
p15	Protein
p21	Protein
p27	Protein
p38	Protein

Annotated Interactions

No annotated interactions