Notch signaling pathway (Bos taurus)

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PM->NUDeubiquitinationGene SymbolMethylation(Protein-protein interaction)DephosphorylationMolecule in the pathwayENPM->CYDesumoylationCytoplasmPhosphorylationRecruitmentInhibitionGamma secretase complexProteolytic CleavageGONU->CYECGlycosylationMTICDICDCY->NUNU->CYICDPalmitoylationPM->NUTranslocationSumoylationPM->NUICDMolecular associationPlasma membraneDDDEndoplasmic reticulumAccession Number: NetPath 3; cellmap:3CY->NUGO->PMEnzyme complexGO->PMAutophosphorylationDeacetylationDemethylationReceptorProteins in a complex interactionPM-- ICDIntracellular DomainExtracellularICDDNUDDActivationPM->NUUbiquitinationLigandERMitochondrionControlAcetylationNU->CYCY->NUCY->NUNucleusCY->NUGolgi apparatusReactioin through unknown mechanisms/moleculesCYEndosomeICDSMAD1TP53HES5NCOR1APH1BEGFSKP2LFNGSAP30NOTCH1DTX1SNW1GSK3BHES6NOTCH2RBX1JAG2LCKNOTCH2NOTCH2PIK3R2CDK2NOTCH3MAPK3NOTCH4HEY1CNTFRJAG2YY1FURINFHL1NCOR2JAG1NOTCH2MFNGMAML3SKP2EP300LOC509866CIRCNTFNOVADAM10STAT3NOTCH1MAML2RELAKAT2BDLL1SMAD3APPGSK3BAPH1ACUL1MAGEA1NCOR2LEF1CNTN1NOTCH4STAT3JUNDLL4NUMBNOTCH3WDR12HES1NFKBIADTX1PSEN1DLL1MAPK1RELASPENNOTCH1NOTCH1HDAC2HDAC1JAK2NOTCH1NOTCH3TLE1DLL4NOTCH1ITCHSIN3AJAG2NUMBLPOFUT1ASCL1JAG1EP300PSEN2PIK3R1FBXW7ZFPM1LOC511264MAML1SMAD4LOC511264JAG1RBPJNCSTNADAM17RING1PSENENAKT1NCOR1HEY2TCF3MEF2CEGFRDLL1


Description

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Comments

GenMAPP notes 
NetPath 3; cellmap:3 - Delta-Notch Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP61(r20805) with a 81% conversion rate.

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117573view11:22, 21 May 2021EweitzModified title
115960view08:26, 22 March 2021EgonwCopied the NetPath paper into the literature list
115950view07:13, 22 March 2021EgonwModified description
80867view15:29, 30 June 2015Mkutmonhomology conversion
67147view10:12, 26 June 2013Christine ChichesterOntology Term : 'Notch signaling pathway' added !
63356view22:22, 9 May 2013MaintBotUpdated to 2013 gpml schema
40530view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
35713view23:19, 12 February 2010AlexanderPico
33772view00:06, 9 December 2009MaintBotAutomatic update of empty xrefs
32522view12:56, 17 August 2009MaintBotFixed text labels
31220view19:41, 13 August 2009MaintBotFixed text labels
30633view22:27, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADAM10GeneProduct282132 (Entrez Gene)
ADAM17GeneProduct517541 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
APH1AGeneProduct539247 (Entrez Gene)
APH1BGeneProduct530913 (Entrez Gene)
APPGeneProduct280722 (Entrez Gene)
ASCL1GeneProduct540473 (Entrez Gene)
CDK2GeneProduct519217 (Entrez Gene)
CIRGeneProduct
CNTFGeneProduct
CNTFRGeneProduct539548 (Entrez Gene)
CNTN1GeneProduct281705 (Entrez Gene)
CUL1GeneProduct539792 (Entrez Gene)
DLL1GeneProduct788775 (Entrez Gene)
DLL4GeneProduct518746 (Entrez Gene)
DTX1GeneProduct512873 (Entrez Gene)
EGFGeneProduct786061 (Entrez Gene)
EGFRGeneProduct407217 (Entrez Gene)
EP300GeneProduct
FBXW7GeneProduct540932 (Entrez Gene)
FHL1GeneProduct509056 (Entrez Gene)
FURINGeneProduct281374 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
HDAC1GeneProduct404126 (Entrez Gene)
HDAC2GeneProduct407223 (Entrez Gene)
HES1GeneProduct539547 (Entrez Gene)
HES5GeneProduct787633 (Entrez Gene)
HES6GeneProduct531384 (Entrez Gene)
HEY1GeneProduct408005 (Entrez Gene)
HEY2GeneProduct538619 (Entrez Gene)
ITCHGeneProduct508431 (Entrez Gene)
JAG1GeneProduct783681 (Entrez Gene)
JAG2GeneProduct517405 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
KAT2BGeneProduct407215 (Entrez Gene)
LCKGeneProduct508890 (Entrez Gene)
LEF1GeneProduct535399 (Entrez Gene)
LFNGGeneProduct516209 (Entrez Gene)
LOC509866GeneProduct509866 (Entrez Gene)
LOC511264GeneProduct511264 (Entrez Gene)
MAGEA1GeneProduct
MAML1GeneProduct
MAML2GeneProduct521194 (Entrez Gene)
MAML3GeneProduct540588 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MEF2CGeneProduct512254 (Entrez Gene)
MFNGGeneProduct505267 (Entrez Gene)
NCOR1GeneProduct507663 (Entrez Gene)
NCOR2GeneProduct
NCSTNGeneProduct514929 (Entrez Gene)
NFKBIAGeneProduct282291 (Entrez Gene)
NOTCH1GeneProduct767866 (Entrez Gene)
NOTCH2GeneProduct513730 (Entrez Gene)
NOTCH3GeneProduct
NOTCH4GeneProduct537814 (Entrez Gene)
NOVGeneProduct505727 (Entrez Gene)
NUMBGeneProduct512187 (Entrez Gene)
NUMBLGeneProduct510973 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
POFUT1GeneProduct360194 (Entrez Gene)
PSEN1GeneProduct282705 (Entrez Gene)
PSEN2GeneProduct282010 (Entrez Gene)
PSENENGeneProduct493993 (Entrez Gene)
RBPJGeneProduct767928 (Entrez Gene)
RBX1GeneProduct518880 (Entrez Gene)
RELAGeneProduct508233 (Entrez Gene)
RING1GeneProduct100125778 (Entrez Gene)
SAP30GeneProduct781150 (Entrez Gene)
SIN3AGeneProduct518504 (Entrez Gene)
SKP2GeneProduct519018 (Entrez Gene)
SMAD1GeneProduct540488 (Entrez Gene)
SMAD3GeneProduct515125 (Entrez Gene)
SMAD4GeneProduct540248 (Entrez Gene)
SNW1GeneProduct326578 (Entrez Gene)
SPENGeneProduct513692 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
TCF3GeneProduct530616 (Entrez Gene)
TLE1GeneProduct512888 (Entrez Gene)
TP53GeneProduct281542 (Entrez Gene)
WDR12GeneProduct528209 (Entrez Gene)
YY1GeneProduct534353 (Entrez Gene)
ZFPM1GeneProduct528338 (Entrez Gene)

Annotated Interactions

No annotated interactions
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