FAS pathway and stress induction of HSP regulation (Canis familiaris)

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1Necrosis3x-PCutDNA presentationActivateFAS PathwayMitochondria PathwayApoptosome3x-PNFK-B PathwayCytoplasmROSStress Induction of HSP regulationExtracellularStressCell SurvivalProteasomeSelf-activationInhibition3x-PNucleusCASP3CASP8FADDPhosphateDAXXCASP8PhosphateARHGDIBLMNB1FAF1CFLARMAP3K7JUNCASP7MAPKAPK3PhosphateHSPB1LMNB2FASDAXXDFFBIL1ACYCSPhosphateFAP1HSPB1CASP10PhosphateAPAF1HSPB1PARP1PhosphateFASLGGlutathioneHSPB1RIPK2HSPB1MAP2K4SPTAN1MAP3K1APAF1BCL2HSPB1HSPB1CASP9FAF1RB1PhosphateactinMAPKAPK2CASP3DFFALMNAPhosphateMAPK8DFFBHSPB1ApoptosisPRKDCPAK2CeramideTNFCASP6PAK1


Description

This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP314(r45253) with a 88% conversion rate.

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Ontology Terms

 

Bibliography

  1. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117076view14:45, 16 May 2021EweitzModified title
114231view21:45, 27 December 2020Andraconnect unconnected line
114091view08:46, 22 December 2020EgonwMade a pathway clickable
106047view11:56, 16 August 2019MaintBotHMDB identifier normalization
68520view22:03, 5 July 2013MaintBotUpdated to 2013 gpml schema
67220view10:22, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
48166view20:25, 9 May 2012MaintBotUpdating from human to fix xrefs
40674view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
38227view21:07, 27 August 2010KhanspersRemoved receptors and Protein Complex graphics
35555view14:59, 12 February 2010ThomasModified description
35552view14:57, 12 February 2010Thomasadded literature
33964view18:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32567view13:11, 17 August 2009MaintBotFixed text labels
32246view12:54, 15 August 2009MaintBotFixed text labels
31759view12:05, 14 August 2009MaintBotFixed group labels
31265view19:56, 13 August 2009MaintBotFixed text labels
30707view22:51, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APAF1GeneProduct482620 (Entrez Gene)
ARHGDIBGeneProduct486666 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
ApoptosisPathwayWP254 (WikiPathways)
BCL2GeneProduct403416 (Entrez Gene)
CASP10GeneProduct488472 (Entrez Gene)
CASP3GeneProduct403567 (Entrez Gene)
CASP6GeneProduct487899 (Entrez Gene)
CASP7GeneProduct
CASP8GeneProduct488473 (Entrez Gene)
CASP9GeneProduct487432 (Entrez Gene)
CFLARGeneProduct488471 (Entrez Gene)
CYCSGeneProduct475258 (Entrez Gene)
CeramideMetabolite104404-17-3 (CAS)
DAXXGeneProduct474873 (Entrez Gene)
DFFAGeneProduct487449 (Entrez Gene)
DFFBGeneProduct489623 (Entrez Gene)
FADDGeneProduct
FAF1GeneProduct608231 (Entrez Gene)
FAP1GeneProduct
FASGeneProduct486469 (Entrez Gene)
FASLGGeneProduct442968 (Entrez Gene)
GlutathioneMetaboliteHMDB00125 (HMDB)
HSPB1GeneProduct403979 (Entrez Gene)
IL1AGeneProduct403782 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
LMNAGeneProduct480124 (Entrez Gene)
LMNB1GeneProduct474663 (Entrez Gene)
LMNB2GeneProduct485070 (Entrez Gene)
MAP2K4GeneProduct
MAP3K1GeneProduct478061 (Entrez Gene)
MAP3K7GeneProduct
MAPK8GeneProduct477746 (Entrez Gene)
MAPKAPK2GeneProduct490263 (Entrez Gene)
MAPKAPK3GeneProduct484756 (Entrez Gene)
PAK1GeneProduct607885 (Entrez Gene)
PAK2GeneProduct612814 (Entrez Gene)
PARP1GeneProduct490385 (Entrez Gene)
PRKDCGeneProduct474176 (Entrez Gene)
PhosphateMetaboliteHMDB01429 (HMDB)
RB1GeneProduct476915 (Entrez Gene)
RIPK2GeneProduct477936 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
SPTAN1GeneProduct403484 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TNFGeneProduct403922 (Entrez Gene)
actinGeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1138"
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