IL-2 signaling pathway (Canis familiaris)

From WikiPathways

Revision as of 00:57, 26 February 2014 by MaintBot (Talk | contribs)
Jump to: navigation, search
NucleusLigandCY -> NUAcetylationPhosphorylationCY -> NUPalmitolyation(Protein-protein interaction)CY -> NUCY -> NUProteolytic cleavageDemethylationCY -> NUCY -> NUEndoplasmic reticulumDDMitochondrionPhosphorylationDTranslocationRecruitmentAutophosphorylationDSumoylationDephosphorylationDControlMolecule in the pathwayPMMTECNucleusDDesumoylationAccession Number: NetPath 14EndosomeERDCYProteins in a complex interactionReactions through unknown mechanisms/moleculesExtracellularGOCytoplasmENPlasma membraneDEnzyme complexDNUGene SymbolPM -> CYActivationMolecular associationNUCY -> NUDInhibitionReceptorMTUbiquitinationDDeubiquitinationMethylationDeacetylationGolgi apparatusGlycosylationCY -> PMCY -> NUDYBX1STAT5BCISHCHUKIL2RGRPS6KB1CRKLSTAT5APRKCZCD53SHBLOC480438CRKPIK3R2BCL2PLCB1STAM2NR3C1IRS2GRB2AKT1SOCS1LCKSOS1STAT1EIF4ECBLFYNIL2MAPK3PIK3R1PIK3CDAKT1IL2SYKMAP2K2CREB1FOXO3AETS1STAMSTAT5BIL2RANFKB1ITM2BSTAT3PIK3CGTERTIL2SOCS3ETS2IFNA1NFKB1MAPK14AKT1JAK2MAP2K1HRASMAPK3PIK3CBIL2CRKRAF1VAV1PTPN11NMISHC1RELAPTPN6RELAMAPK8MAPKAPK2YBX1GAB2EIF3BJAK3MKNK1LYNJAK1MAPK9MAPK1TERTPTK2BMAPK1IL2IL2RBRAF1GNB2L1MTORIRS1PIK3CASTAT5AICAM1


Description

Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_14

Comments

GenMAPP notes 
NetPath 14 - IL-2 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 94% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117468view10:56, 21 May 2021EweitzModified title
115955view08:21, 22 March 2021EgonwCopied the NetPath paper into the literature list
115945view07:11, 22 March 2021EgonwModified description
89851view12:18, 6 October 2016Mkutmonremove GenMAPP notes
89847view12:16, 6 October 2016MkutmonModified description
73856view00:57, 26 February 2014MaintBotupdated schema
67366view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
40686view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
35785view06:21, 13 February 2010MaintBotAdded description
32539view13:02, 17 August 2009MaintBotFixed text labels
31237view19:46, 13 August 2009MaintBotFixed text labels
30660view22:36, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
BCL2GeneProduct403416 (Entrez Gene)
CBLGeneProduct
CD53GeneProduct610454 (Entrez Gene)
CHUKGeneProduct477796 (Entrez Gene)
CISHGeneProduct484757 (Entrez Gene)
CREB1GeneProduct607922 (Entrez Gene)
CRKGeneProduct
CRKLGeneProduct608125 (Entrez Gene)
EIF3BGeneProduct479766 (Entrez Gene)
EIF4EGeneProduct487870 (Entrez Gene)
ETS1GeneProduct489287 (Entrez Gene)
ETS2GeneProduct487761 (Entrez Gene)
FOXO3AGeneProduct
FYNGeneProduct475032 (Entrez Gene)
GAB2GeneProduct485167 (Entrez Gene)
GNB2L1GeneProduct480818 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
HRASGeneProduct403735 (Entrez Gene)
ICAM1GeneProduct403975 (Entrez Gene)
IFNA1GeneProduct
IL2GeneProduct403989 (Entrez Gene)
IL2RAGeneProduct403870 (Entrez Gene)
IL2RBGeneProduct403439 (Entrez Gene)
IL2RGGeneProduct403851 (Entrez Gene)
IRS1GeneProduct486148 (Entrez Gene)
IRS2GeneProduct485548 (Entrez Gene)
ITM2BGeneProduct476916 (Entrez Gene)
JAK1GeneProduct442952 (Entrez Gene)
JAK2GeneProduct484185 (Entrez Gene)
JAK3GeneProduct610004 (Entrez Gene)
LCKGeneProduct478151 (Entrez Gene)
LOC480438GeneProduct480438 (Entrez Gene)
LYNGeneProduct477886 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAPK14GeneProduct403856 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MAPKAPK2GeneProduct490263 (Entrez Gene)
MKNK1GeneProduct482509 (Entrez Gene)
MTORGeneProduct478232 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
NMIGeneProduct476146 (Entrez Gene)
NR3C1GeneProduct478047 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
PIK3CBGeneProduct477085 (Entrez Gene)
PIK3CDGeneProduct489644 (Entrez Gene)
PIK3CGGeneProduct483266 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PLCB1GeneProduct485773 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PTK2BGeneProduct486102 (Entrez Gene)
PTPN11GeneProduct477488 (Entrez Gene)
PTPN6GeneProduct486717 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RELAGeneProduct483729 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
SHBGeneProduct481619 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SOCS1GeneProduct490006 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
STAM2GeneProduct476150 (Entrez Gene)
STAMGeneProduct477990 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)
STAT5AGeneProduct490968 (Entrez Gene)
STAT5BGeneProduct490969 (Entrez Gene)
SYKGeneProduct484196 (Entrez Gene)
TERTGeneProduct403412 (Entrez Gene)
VAV1GeneProduct485016 (Entrez Gene)
YBX1GeneProduct479011 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1091"
Personal tools