Calcium regulation in cardiac cells (Canis familiaris)

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1bgK+Protein Kinase AGG alpha i/o/z2+Adrenergic Receptor2+PKC inhibitor Protein-1Na2+Connexing2+CaM kinaseGAdenylyl CyclasesPConnexin2+G alpha i/o/zSRIP3 ReceptorsPhopholambanCaDihydropyridine-SensitiveCaCyclasesbCaM kinaseEpinephrinePKA Inhibitors2+GNa+K+2+CaCalreticulin-Cabeta ArrestincAMPDAGAdenylylIP3RepolarizationK+M1 Muscarinic ReceptorP2+Protein Kinase ACalsequestrin C-CaIP4Cytosolic CabProtein Kinase C2+Na+b2+IP3 ReceptorsCalmodulinADP + PiCaPIP2Cytosolic Ca2+MembraneDepolarizationEpinephrineaCaADP + PiRegulators of G-proteinCytosolAdrenergic ReceptorCa2+L-Type Ca2+ ChannelNa+/K+ ATPaseNa+/Ca2+ ExchangerG2+2+Calsequestrin S-Ca2+SignalingFKBP12GRKbgGCabgCaCytosolic Caarrestin/GRKGap Junctions (Connexins)Ca2+arrestin/GRKbPRKCDRYR3ATPLOC100855806ADRA1DGJB3RGS1PLNGNG13PRKAR2BSLC8A1CALM2PRKAR1AAcetylcholineGNA11ADCY8LOC100856402GJB1PRKAR1BGNG2ADCY5ADCY2ATPCACNA1EGNAI1PLCB3GNG3RGS6RGS4PRKCHGNASRGS14GNB2CASQ1PKIBGNB4ADCY9CACNA1ARGS7YWHAHGRK5GNB3CAMK1ADRA1AGJA4CHRM5ARRB1YWHAQPRKACAGJA5GNAZPLCB3ATPKCNB1GJB6ADCY3PRKCEPRKACBGRK4LOC100686332CALM3RGS3PKIAATP1B3ADRA1BRGS10ATP1B2ITPR3YWHAGFXYD2PRKCBCACNA1BGNG4RGS5ATP1A4ATP2B3ATP2A3GJA3RGS17CASQ2GJC1PRKCGADRB3KCNJ3ADRB1GJD2GNGT1GNG7RGS18PRKCZGJA6PRKCQRYR2GNAI3CHRM3SFNCHRM1RGS2ITPR2GNAI2PRKCACALM1RGS20CHRM4CALRCAMK2GGJC2CACNA1DFKBP1AADCY1GNAO1CACNA1CGNG8GRK6ADRB2GJA9SLC8A3ATPGJA8CACNB1RYR1PRKCHRGS19ADCY7YWHAZCHRM2ATP2B1PRKD1CAMK2ACAMK2DPRKAR2AGNB5ITPR1YWHAECACNB3GNAQCAMK4ANXA6ADCY6ARRB2ATP2B2PKIGKCNJ5ATP2A2GJB5RGS11GJA1CAMK2BATP1B1GJB2CACNA1SGNB1LOC100683432RGS9GJB4ADCY4ADPYWHAB


Description

Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart. Source: Wikipedia

Comments

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This pathway was inferred from Homo sapiens pathway WP536(r44983) with a 94% conversion rate.

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Bibliography

  1. Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117441view10:51, 21 May 2021EweitzModified title
107090view14:17, 17 September 2019MaintBotChEBI identifier normalization
106055view11:57, 16 August 2019MaintBotHMDB identifier normalization
95758view14:13, 19 January 2018MkutmonHomology conversion update
68583view23:10, 5 July 2013MaintBotUpdated to 2013 gpml schema
67771view13:54, 26 June 2013Christine ChichesterOntology Term : 'calcium/calcium-mediated signaling pathway' added !
48161view19:00, 9 May 2012MaintBotUpdating from human to fix xrefs
40742view21:54, 1 March 2011MaintBotRemoved redundant pathway information and comments
35454view11:49, 12 February 2010Thomasadd literature
35453view11:48, 12 February 2010ThomasModified description
34017view18:44, 9 December 2009MaintBotAutomatic update of empty xrefs
32254view12:57, 15 August 2009MaintBotFixed text labels
31775view12:09, 14 August 2009MaintBotFixed group labels
31276view20:00, 13 August 2009MaintBotFixed text labels
30728view22:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY1GeneProduct607357 (Entrez Gene) CYA1 HUMAN
ADCY2GeneProduct478624 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY3GeneProduct482994 (Entrez Gene)
ADCY4GeneProduct480271 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY5GeneProduct403859 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY6GeneProduct477625 (Entrez Gene)
ADCY7GeneProduct487289 (Entrez Gene)
ADCY8GeneProduct482045 (Entrez Gene)
ADCY9GeneProduct490031 (Entrez Gene)
ADPMetabolite58-64-0 (CAS)
ADRA1AGeneProduct403866 (Entrez Gene)
ADRA1BGeneProduct403962 (Entrez Gene)
ADRA1DGeneProduct
ADRB1GeneProduct493972 (Entrez Gene)
ADRB2GeneProduct403910 (Entrez Gene)
ADRB3GeneProduct442979 (Entrez Gene)
ANXA6GeneProduct479325 (Entrez Gene)
ARRB1GeneProduct485189 (Entrez Gene)
ARRB2GeneProduct607262 (Entrez Gene)
ATPMetabolite1927-31-7 (CAS)
ATP1A4GeneProduct488637 (Entrez Gene)
ATP1B1GeneProduct403966 (Entrez Gene)
ATP1B2GeneProduct489479 (Entrez Gene)
ATP1B3GeneProduct477098 (Entrez Gene)
ATP2A2GeneProduct403878 (Entrez Gene)
ATP2A3GeneProduct491437 (Entrez Gene)
ATP2B1GeneProduct403480 (Entrez Gene)
ATP2B2GeneProduct476535 (Entrez Gene)
ATP2B3GeneProduct492238 (Entrez Gene)
AcetylcholineMetabolite51-84-3 (CAS)
CACNA1AGeneProduct100686650 (Entrez Gene)
CACNA1BGeneProduct480660 (Entrez Gene)
CACNA1CGeneProduct403516 (Entrez Gene)
CACNA1DGeneProduct484724 (Entrez Gene)
CACNA1EGeneProduct490305 (Entrez Gene)
CACNA1SGeneProduct490244 (Entrez Gene)
CACNB1GeneProduct491030 (Entrez Gene)
CACNB3GeneProduct486563 (Entrez Gene)
CALM1GeneProduct
CALM2GeneProduct
CALM3GeneProduct
CALRGeneProduct476694 (Entrez Gene)
CAMK1GeneProduct484665 (Entrez Gene)
CAMK2AGeneProduct612941 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct610764 (Entrez Gene)
CAMK2GGeneProduct489050 (Entrez Gene)
CAMK4GeneProduct100684140 (Entrez Gene)
CASQ1GeneProduct608401 (Entrez Gene)
CASQ2GeneProduct483134 (Entrez Gene)
CHRM1GeneProduct483776 (Entrez Gene)
CHRM2GeneProduct403858 (Entrez Gene)
CHRM3GeneProduct403827 (Entrez Gene)
CHRM4GeneProduct611314 (Entrez Gene)
CHRM5GeneProduct487472 (Entrez Gene)
FKBP1AGeneProduct100686033 (Entrez Gene)
FXYD2GeneProduct608594 (Entrez Gene)
GJA1GeneProduct403418 (Entrez Gene)
GJA3GeneProduct486052 (Entrez Gene)
GJA4GeneProduct482485 (Entrez Gene)
GJA5GeneProduct483155 (Entrez Gene)
GJA6GeneProduct
GJA8GeneProduct483156 (Entrez Gene)
GJA9GeneProduct100684742 (Entrez Gene)
GJB1GeneProduct480953 (Entrez Gene)
GJB2GeneProduct403570 (Entrez Gene)
GJB3GeneProduct482486 (Entrez Gene)
GJB4GeneProduct482487 (Entrez Gene)
GJB5GeneProduct482488 (Entrez Gene)
GJB6GeneProduct100688824 (Entrez Gene)
GJC1GeneProduct490936 (Entrez Gene)
GJC2GeneProduct607294 (Entrez Gene)
GJD2GeneProduct487477 (Entrez Gene)
GNA11GeneProduct403914 (Entrez Gene)
GNAI1GeneProduct478227 (Entrez Gene)
GNAI2GeneProduct442957 (Entrez Gene)
GNAI3GeneProduct611810 (Entrez Gene)
GNAO1GeneProduct609157 (Entrez Gene)
GNAQGeneProduct403928 (Entrez Gene)
GNASGeneProduct403943 (Entrez Gene)
GNAZGeneProduct607445 (Entrez Gene)
GNB1GeneProduct403912 (Entrez Gene)
GNB2GeneProduct479733 (Entrez Gene)
GNB3GeneProduct403511 (Entrez Gene)
GNB4GeneProduct488087 (Entrez Gene)
GNB5GeneProduct608623 (Entrez Gene)
GNG13GeneProduct611349 (Entrez Gene)
GNG2GeneProduct610817 (Entrez Gene)
GNG3GeneProduct483783 (Entrez Gene)
GNG4GeneProduct607513 (Entrez Gene)
GNG7GeneProduct612139 (Entrez Gene)
GNG8GeneProduct484428 (Entrez Gene)
GNGT1GeneProduct403895 (Entrez Gene)
GRK4GeneProduct479075 (Entrez Gene)
GRK5GeneProduct486915 (Entrez Gene)
GRK6GeneProduct100684653 (Entrez Gene)
ITPR1GeneProduct476548 (Entrez Gene)
ITPR2GeneProduct486628 (Entrez Gene)
ITPR3GeneProduct481746 (Entrez Gene)
KCNB1GeneProduct485918 (Entrez Gene)
KCNJ3GeneProduct488355 (Entrez Gene)
KCNJ5GeneProduct489284 (Entrez Gene)
LOC100683432GeneProduct100683432 (Entrez Gene)
LOC100686332GeneProduct100686332 (Entrez Gene)
LOC100855806GeneProduct100855806 (Entrez Gene)
LOC100856402GeneProduct100856402 (Entrez Gene)
PKIAGeneProduct610744 (Entrez Gene)
PKIBGeneProduct100683903 (Entrez Gene)
PKIGGeneProduct610925 (Entrez Gene)
PLCB3GeneProduct476034 (Entrez Gene)
PLNGeneProduct414755 (Entrez Gene)
PRKACAGeneProduct403556 (Entrez Gene)
PRKACBGeneProduct479975 (Entrez Gene)
PRKAR1AGeneProduct480459 (Entrez Gene) KAP0 HUMAN
PRKAR1BGeneProduct480805 (Entrez Gene)
PRKAR2AGeneProduct100685147 (Entrez Gene)
PRKAR2BGeneProduct475887 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PRKCEGeneProduct609934 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
PRKCGGeneProduct
PRKCHGeneProduct490722 (Entrez Gene)
PRKCQGeneProduct478013 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PRKD1GeneProduct609091 (Entrez Gene) KPCM HUMAN
RGS10GeneProduct477840 (Entrez Gene)
RGS11GeneProduct611545 (Entrez Gene)
RGS14GeneProduct489092 (Entrez Gene)
RGS1GeneProduct488585 (Entrez Gene)
RGS17GeneProduct608867 (Entrez Gene)
RGS18GeneProduct607858 (Entrez Gene)
RGS19GeneProduct491407 (Entrez Gene)
RGS20GeneProduct486954 (Entrez Gene)
RGS2GeneProduct488584 (Entrez Gene)
RGS3GeneProduct
RGS4GeneProduct488666 (Entrez Gene)
RGS5GeneProduct488667 (Entrez Gene)
RGS6GeneProduct480380 (Entrez Gene)
RGS7GeneProduct100687600 (Entrez Gene)
RGS9GeneProduct
RYR1GeneProduct606491 (Entrez Gene)
RYR2GeneProduct403615 (Entrez Gene)
RYR3GeneProduct100686627 (Entrez Gene)
SFNGeneProduct487351 (Entrez Gene)
SLC8A1GeneProduct475738 (Entrez Gene)
SLC8A3GeneProduct490755 (Entrez Gene)
YWHABGeneProduct477237 (Entrez Gene)
YWHAEGeneProduct480645 (Entrez Gene)
YWHAGGeneProduct489818 (Entrez Gene)
YWHAHGeneProduct100687866 (Entrez Gene)
YWHAQGeneProduct607060 (Entrez Gene)
YWHAZGeneProduct475864 (Entrez Gene) PMID: 9861170 PMID: 1317796

Annotated Interactions

No annotated interactions
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