Non-homologous end joining (Anopheles gambiae)

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XRCC5RAD50PRKDCXRCC4PRKDCXLFXRCC5XRCC5NHEJ1PRKDCXRCC6XRCC6XRCC5XRCC6XRCC5PRKDCLigase VMRE11ANbs1 ?XRCC5XRCC6XRCC6XRCC6XRCC6PRKDCXRCC5XRCC6XRCC5PRKDCXRCC5PRKDCXRCC4XRCC6Ligase VXRCC5XRCC6PRKDC


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r35395) with a 89% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
87941view13:04, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87939view13:04, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
79418view23:33, 21 March 2015Khanspersupdate schema
79417view23:32, 21 March 2015KhanspersReverted to version '22:59, 20 February 2013' by Khanspers
68437view19:10, 5 July 2013MaintBotUpdated to 2013 gpml schema
58803view22:59, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40468view18:47, 1 March 2011MaintBotRemoved redundant pathway information and comments
35402view09:54, 12 February 2010MartijnVanIerselModified description
31829view12:26, 14 August 2009MaintBotFixed group labels
30791view23:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Ligase VGeneProduct
MRE11AGeneProductENSSSCG00000014955 (Ensembl)
NHEJ1GeneProductENSSSCG00000016205 (Ensembl)
Nbs1 ?GeneProduct
PRKDCGeneProductENSSSCG00000006274 (Ensembl)
RAD50GeneProductENSSSCG00000014280 (Ensembl)
XLFGeneProduct
XRCC4GeneProductENSSSCG00000014135 (Ensembl)
XRCC5GeneProductENSSSCG00000016177 (Ensembl)
XRCC6GeneProductENSSSCG00000000059 (Ensembl)

Annotated Interactions

No annotated interactions
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