Methylation (Canis familiaris)
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S-methylation
SAM synthesis (co-substrate)
O-methylation
N-methylation
Substrate
O-methylated substrate
ATP
S-Adenosylmethionine
PNMT
S-Adenosylmethionine
S-Adenosylhomocysteine
HNMT
Phosphate
S-Adenosylhomocysteine
TPMT_CANFA
S-Adenosylmethionine
N-methylated substrate
NNMT
L-Methionine
S-methylated substrate
MAT2A
Phosphate
NP_001004074.1
INMT
MAT2B
MAT1A
S-Adenosylhomocysteine
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP704(r30265)
with a 88% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006
PubMed
Europe PMC
Scholia
Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
118131
view
10:35, 25 May 2021
Eweitz
Modified title
106035
view
11:56, 16 August 2019
MaintBot
HMDB identifier normalization
87825
view
11:43, 25 July 2016
Elisa
Ontology Term : 'classic metabolic pathway' added !
87824
view
11:42, 25 July 2016
Elisa
Ontology Term : 'PW:0000003' removed !
87823
view
11:41, 25 July 2016
Elisa
Ontology Term : 'signaling pathway' added !
68601
view
23:27, 5 July 2013
MaintBot
Updated to 2013 gpml schema
58857
view
23:35, 20 February 2013
MaintBot
Updated Ensembl and UniProt data source
40761
view
21:55, 1 March 2011
MaintBot
Removed redundant pathway information and comments
34032
view
18:49, 9 December 2009
MaintBot
Automatic update of empty xrefs
31734
view
11:58, 14 August 2009
MaintBot
Fixed group labels
30678
view
22:42, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ATP
Metabolite
HMDB00538 (HMDB)
HNMT
GeneProduct
ENSCAFG00000005178 (Ensembl)
INMT
GeneProduct
489397 (Entrez Gene)
L-Methionine
Metabolite
HMDB00696 (HMDB)
MAT1A
GeneProduct
ENSCAFG00000015807 (Ensembl)
MAT2A
GeneProduct
ENSCAFG00000007755 (Ensembl)
MAT2B
GeneProduct
ENSCAFG00000017181 (Ensembl)
N-methylated substrate
Metabolite
NNMT
GeneProduct
ENSCAFG00000013523 (Ensembl)
NP_001004074.1
GeneProduct
ENSCAFG00000014253 (Ensembl)
O-methylated substrate
Metabolite
PNMT
GeneProduct
ENSCAFG00000016368 (Ensembl)
Phosphate
Metabolite
HMDB01429 (HMDB)
S-Adenosylhomocysteine
Metabolite
HMDB00939 (HMDB)
S-Adenosylmethionine
Metabolite
HMDB01185 (HMDB)
S-methylated substrate
Metabolite
Substrate
Metabolite
TPMT_CANFA
GeneProduct
ENSCAFG00000010160 (Ensembl)
Annotated Interactions
No annotated interactions
Views
Pathway
Discussion
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