EGFR1 signaling pathway (Danio rerio)

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1NUNUEndoplasmic reticulumCYPhosphorylationAccession Number : NetPath 4; cellmap:4DPMPMGlycosylationCYCYCYNUMAMAAcetylationMitochondrionNUCYDENECPMCYReaction through unknown mechanisms/moleculesMolecule in the pathwayDeubiquitinationCYAutophosphorylationCYNUMACYCYPMMAInhibitionCYDDephosphorylationGOCYPMPlasma membraneSumoylationControlCYPMRecruitmentCYCYDemethylationPalmitoylationPMNUMolecular associationGene SymbolPMPMNUTranslocationMAMAPMMAPMCYCYPMCYGolgi apparatusNUCYNUERMANUNUMA(Protein-protein interaction)PMAutodephosphorylationPMCYEndosomePMPMNucleusMTCYNUMAProteolytic cleavageMAMAMACYNUMANUCYMethylationUbiquitinationCYPMDesumoylationCYCYCYProteins in a complex interactionNUCYPMDeacetylationActivationENMAMACytoplasmMACYNUNUENCYMAEnzyme complexCYReceptorPMMAPMExtracellularNUNUCYCYCYCYMANUMAPMPMLigandrps6ka3bzgc:172250mapk1appl2egfrsi:dkeyp-192m14.7stat1aVAV2map3k3srccav2hdac1tgif1sh2d3caLOC100007590stat3crkzgc:110206si:ch211-197i12.3zgc:162129zgc:172209crklegfrspry2MAP2K3APPLelf3zgc:92024STAT5Acebpbrbb4lEPN1SIN3ALOC792354mapk7LOC100151336gab1ralbmapk14aEEF1A1LOC558321cav1STAT5Brps6ka3bMYCPLD1APPLVAV1FOXO1Azgc:64130APPLtnip1zgc:56041KRT17zgc:77033prkczSOS1YWHABappl2PLD1SOCS3cblplcg1LOC100149498egfrLOC560913CH211-251J10.3pxnpld2LOC100003514prkcikraswu:fk86g11waslaSTAT5Adusp1smad2CH211-125M10.3LOC557201junddnm2mapk1HIST3H3PLSCR1fosLOC562134LOC561737LOC564899wu:fc58a04plcg2rac1FOXO1Awu:fb92a07CSKsh3gl2ripk1lhttsp1LOC565173rasa1REPS2cebpaNCK1jak2bwu:fc83c01raf1znf259map2k1LOC564517egfstat3grb2mapk3LOC795505KLF11KRT18LOC100149498ptk2bbplcg1LOC100149671ptpn6pik3r2DOK2egfLOC793823spry2creb1cblbRAB5ASH3KBP1map2k1GRB7zgc:76867prkcb1PLEC1LOC557176ARF4LOC100008005STAT2DDEF1smad2nrasLOC562032SNRPD2LOC567895pik3r3LOC563639KRT8ARF4LOC571285LOC568321pitpnaraf1NDUFA13gab1zgc:175192EEF1A1ptpn11PTPN12hat1SNCApak1LOC558321egfrPTK6ARF4egfzgc:112145zgc:92074atf1socs1LOC559524ptpn6zgc:172137stat1asmad3bzgc:158742sh3gl2MAP3K14mta2cdc42lLOC558153pik3cdstxbp1plcg2si:ch211-240l19.1zgc:175192LOC559119camk2aELK4CEACAM1CH211-67F24.8smad3bCBLCLOC795505LOC571965rps6ka3acasp9sh2d3caLOC557123zgc:153534dusp1si:dkey-217m5.1stat1aLOC568935HRASelf3LOC563639stat3pbpSTAT2junjak1im:7150469znf259stxbp1cx43LOC556726


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 76% conversion rate.

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Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116858view10:54, 14 May 2021EweitzModified title
68672view05:30, 6 July 2013MaintBotUpdated to 2013 gpml schema
67176view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
40845view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35723view23:30, 12 February 2010AlexanderPico
35433view11:29, 12 February 2010MichielAdded ref
34227view21:36, 9 December 2009MaintBotAutomatic update of empty xrefs
31033view01:15, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APPLGeneProduct
ARF4GeneProduct
CBLCGeneProduct
CEACAM1GeneProduct114465 (Entrez Gene)
CH211-125M10.3GeneProduct558144 (Entrez Gene)
CH211-251J10.3GeneProduct799483 (Entrez Gene)
CH211-67F24.8GeneProduct561670 (Entrez Gene)
CSKGeneProduct556454 (Entrez Gene)
DDEF1GeneProduct326709 (Entrez Gene)
DOK2GeneProduct
EEF1A1GeneProduct
ELK4GeneProduct30093 (Entrez Gene)
EPN1GeneProduct406671 (Entrez Gene)
FOXO1AGeneProduct768121 (Entrez Gene)
GRB7GeneProduct
HIST3H3GeneProduct
HRASGeneProduct550286 (Entrez Gene)
KLF11GeneProduct
KRT17GeneProduct
KRT18GeneProduct352912 (Entrez Gene)
KRT8GeneProduct797433 (Entrez Gene)
LOC100003514GeneProduct100003514 (Entrez Gene)
LOC100007590GeneProduct100007590 (Entrez Gene)
LOC100008005GeneProduct100008005 (Entrez Gene)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC100149671GeneProduct100149671 (Entrez Gene)
LOC100151336GeneProduct100151336 (Entrez Gene)
LOC556726GeneProduct556726 (Entrez Gene)
LOC557123GeneProduct557123 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC557201GeneProduct557201 (Entrez Gene)
LOC558153GeneProduct558153 (Entrez Gene)
LOC558321GeneProduct558321 (Entrez Gene)
LOC559119GeneProduct559119 (Entrez Gene)
LOC559524GeneProduct559524 (Entrez Gene)
LOC560913GeneProduct560913 (Entrez Gene)
LOC561737GeneProduct561737 (Entrez Gene)
LOC562032GeneProduct562032 (Entrez Gene)
LOC562134GeneProduct562134 (Entrez Gene)
LOC563639GeneProduct563639 (Entrez Gene)
LOC564517GeneProduct564517 (Entrez Gene)
LOC564899GeneProduct564899 (Entrez Gene)
LOC565173GeneProduct565173 (Entrez Gene)
LOC567895GeneProduct567895 (Entrez Gene)
LOC568321GeneProduct568321 (Entrez Gene)
LOC568935GeneProduct568935 (Entrez Gene)
LOC571285GeneProduct571285 (Entrez Gene)
LOC571965GeneProduct571965 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
LOC793823GeneProduct793823 (Entrez Gene)
LOC795505GeneProduct795505 (Entrez Gene)
MAP2K3GeneProduct
MAP3K14GeneProduct
MYCGeneProduct
NCK1GeneProduct
NDUFA13GeneProduct
PLD1GeneProduct
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PLSCR1GeneProduct
PTK6GeneProduct
PTPN12GeneProduct393642 (Entrez Gene)
RAB5AGeneProduct337737 (Entrez Gene)
REPS2GeneProduct
SH3KBP1GeneProduct
SIN3AGeneProduct
SNCAGeneProduct
SNRPD2GeneProduct550244 (Entrez Gene)
SOCS3GeneProduct
SOS1GeneProduct
STAT2GeneProduct565200 (Entrez Gene)
STAT5AGeneProduct
STAT5BGeneProduct
VAV1GeneProduct
VAV2GeneProduct
YWHABGeneProduct
appl2GeneProduct100000135 (Entrez Gene)
atf1GeneProduct325609 (Entrez Gene)
camk2aGeneProduct550436 (Entrez Gene)
casp9GeneProduct492763 (Entrez Gene)
cav1GeneProduct323695 (Entrez Gene)
cav2GeneProduct415240 (Entrez Gene)
cblGeneProduct492364 (Entrez Gene)
cblbGeneProduct556277 (Entrez Gene)
cdc42lGeneProduct793158 (Entrez Gene)
cebpaGeneProduct140815 (Entrez Gene)
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creb1GeneProduct573207 (Entrez Gene)
crkGeneProduct445234 (Entrez Gene)
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cx43GeneProduct30236 (Entrez Gene)
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dusp1GeneProduct406340 (Entrez Gene)
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egfrGeneProduct378478 (Entrez Gene)
elf3GeneProduct560869 (Entrez Gene)
fosGeneProduct394198 (Entrez Gene)
gab1GeneProduct406666 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
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hdac1GeneProduct192302 (Entrez Gene)
httGeneProduct30214 (Entrez Gene)
im:7150469GeneProduct567938 (Entrez Gene)
jak1GeneProduct30280 (Entrez Gene)
jak2bGeneProduct30298 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
jundGeneProduct564873 (Entrez Gene)
krasGeneProduct445289 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
map3k3GeneProduct560211 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk14aGeneProduct65237 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
mapk7GeneProduct541323 (Entrez Gene)
mta2GeneProduct326078 (Entrez Gene)
nrasGeneProduct30380 (Entrez Gene)
pak1GeneProduct373103 (Entrez Gene)
pbpGeneProduct406627 (Entrez Gene)
pik3cdGeneProduct394174 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
pik3r3GeneProduct100000252 (Entrez Gene)
pitpnaGeneProduct393909 (Entrez Gene)
plcg1GeneProduct373867 (Entrez Gene)
plcg2GeneProduct561747 (Entrez Gene)
pld2GeneProduct565743 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
prkciGeneProduct117507 (Entrez Gene)
prkczGeneProduct555737 (Entrez Gene)
ptk2bbGeneProduct245950 (Entrez Gene)
ptpn11GeneProduct333979 (Entrez Gene)
ptpn6GeneProduct335573 (Entrez Gene)
pxnGeneProduct399546 (Entrez Gene)
rac1GeneProduct327204 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
ralbGeneProduct445255 (Entrez Gene)
rasa1GeneProduct100002155 (Entrez Gene)
rbb4lGeneProduct322129 (Entrez Gene)
ripk1lGeneProduct567460 (Entrez Gene)
rps6ka3aGeneProduct338219 (Entrez Gene)
rps6ka3bGeneProduct100009657 (Entrez Gene)
sh2d3caGeneProduct558860 (Entrez Gene)
sh3gl2GeneProduct394091 (Entrez Gene)
si:ch211-197i12.3GeneProduct555476 (Entrez Gene)
si:ch211-240l19.1GeneProduct561159 (Entrez Gene)
si:dkey-217m5.1GeneProduct564535 (Entrez Gene)
si:dkeyp-192m14.7GeneProduct568170 (Entrez Gene)
smad2GeneProduct30639 (Entrez Gene)
smad3bGeneProduct326283 (Entrez Gene)
socs1GeneProduct445073 (Entrez Gene)
sp1GeneProduct324109 (Entrez Gene)
spry2GeneProduct335098 (Entrez Gene)
srcGeneProduct325084 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
stxbp1GeneProduct574003 (Entrez Gene)
tgif1GeneProduct321756 (Entrez Gene)
tnip1GeneProduct449958 (Entrez Gene)
waslaGeneProduct100009637 (Entrez Gene)
wu:fb92a07GeneProduct100002263 (Entrez Gene)
wu:fc58a04GeneProduct325179 (Entrez Gene)
wu:fc83c01GeneProduct325488 (Entrez Gene)
wu:fk86g11GeneProduct559145 (Entrez Gene)
zgc:110206GeneProduct550519 (Entrez Gene)
zgc:112145GeneProduct550427 (Entrez Gene)
zgc:153534GeneProduct767738 (Entrez Gene)
zgc:158742GeneProduct571626 (Entrez Gene)
zgc:162129GeneProduct798009 (Entrez Gene)
zgc:172137GeneProduct100007679 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)
zgc:175192GeneProduct568309 (Entrez Gene)
zgc:56041GeneProduct393212 (Entrez Gene)
zgc:64130GeneProduct394184 (Entrez Gene)
zgc:76867GeneProduct404612 (Entrez Gene)
zgc:77033GeneProduct406598 (Entrez Gene)
zgc:92024GeneProduct445098 (Entrez Gene)
zgc:92074GeneProduct403063 (Entrez Gene)
znf259GeneProduct406382 (Entrez Gene)

Annotated Interactions

No annotated interactions
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