Hedgehog signaling pathway (Drosophila melanogaster)

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1, 2Proteins in a complex interactionCY->PMMolecular AssociationRecruitmentCY->NUPMCytoplasmCY->NUENCY->NUCY->NUDemethylationPalmitoylationInhibitionActivationNucleusLigandReaction through unknown mechanisms/moleculesPM->ENEndoplasmic reticulumECDEREndosomeControlSumoylationDMolecule in the pathwayMitochondrionGolgi apparatus(Protein-protein interaction)Accession Number: NetPath 10; cellmap:10MTDeacetylationGlycosylationReceptorPlasma membraneDeubiquitinationProteolytic cleavageCYGOUbiquitinationAutophosphorylationMethylationEnzyme complexDephosphorylationPhosphorylationDDesumoylationCY->NUNUAcetylationExtracellularTranslocationPM->ENGene Symbolrab23SHHptc1dyrk1aahhipccnb1gli2aDHHSAP18sufuDHHsufugli2aDHHptc1PTCHrab23PTCHSHHIHHIHHgli1gli3crebbpbIGF2SIN3Acdc2SHHccnb1SHHIHHcdc2smosufuPTCHhhipptc1smoGAS1skiahhipgli3PTCHSTK36gli1


Description

The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Comments

GenMAPP notes 
NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP47(r20775) with a 57% conversion rate.

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Ontology Terms

 

Bibliography

  1. Lum L, Beachy PA; ''The Hedgehog response network: sensors, switches, and routers.''; Science, 2004 PubMed Europe PMC Scholia
  2. Mohler J; ''Requirements for hedgehod, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.''; Genetics, 1988 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116922view09:42, 16 May 2021EweitzModified title
79654view11:56, 1 April 2015EgonwRemoved database names when no identifier was given.
79500view15:51, 23 March 2015Ryan.miller
79398view20:18, 21 March 2015Khanspersupdate schema
79397view20:14, 21 March 2015KhanspersReverted to version '10:38, 26 June 2013' by Khanspers
68719view21:48, 6 July 2013MaintBotUpdated to 2013 gpml schema
67329view10:38, 26 June 2013Christine ChichesterOntology Term : 'Hedgehog signaling pathway' added !
40890view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35741view23:52, 12 February 2010AlexanderPico
21714view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:Hedgehog Netpath 10]] moved to [[Pathway:WP492]]: Moved to stable identifier
8516view14:01, 7 January 2008MaintBotAdded to category $category
8514view14:01, 7 January 2008A.PandeyUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DHHGeneProduct558147 (Entrez Gene)
GAS1GeneProduct
IGF2GeneProduct
IHHGeneProduct
PTCHGeneProduct
SAP18GeneProduct393693 (Entrez Gene)
SHHGeneProduct
SIN3AGeneProduct
STK36GeneProduct
ccnb1GeneProduct58025 (Entrez Gene)
cdc2GeneProduct80973 (Entrez Gene)
crebbpbGeneProduct503776 (Entrez Gene)
dyrk1aaGeneProduct100005019 (Entrez Gene)
gli1GeneProduct352930 (Entrez Gene)
gli2aGeneProduct30154 (Entrez Gene)
gli3GeneProduct403042 (Entrez Gene)
hhipGeneProduct326102 (Entrez Gene)
ptc1GeneProduct30181 (Entrez Gene)
rab23GeneProduct553778 (Entrez Gene)
skiaGeneProduct30101 (Entrez Gene)
smoGeneProduct30225 (Entrez Gene)
sufuGeneProduct100001615 (Entrez Gene)

Annotated Interactions

No annotated interactions
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