Neurotransmitter uptake and metabolism In glial cells (Homo sapiens)

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412, 3cytosolNH4+OrthophosphateADPATPL-GlutamineGLUL decamerL-GlutamateAstrocytic EAATsSystem N amino acid transporter 1L-GlutamineL-Glutamate2


Description

Neuotransmitter uptake by astrocytes is mediated by specific transporter located on the astrocytic membrane. The imported neurotransmitter in the astrocytes is metabolized and transported back to the neuron via specialized transporters.

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Ontology Terms

 

Bibliography

  1. Häberle J, Görg B, Rutsch F, Schmidt E, Toutain A, Benoist JF, Gelot A, Suc AL, Höhne W, Schliess F, Häussinger D, Koch HG.; ''Congenital glutamine deficiency with glutamine synthetase mutations.''; PubMed Europe PMC Scholia
  2. Gegelashvili M, Rodriguez-Kern A, Pirozhkova I, Zhang J, Sung L, Gegelashvili G.; ''High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes.''; PubMed Europe PMC Scholia
  3. Maragakis NJ, Dietrich J, Wong V, Xue H, Mayer-Proschel M, Rao MS, Rothstein JD.; ''Glutamate transporter expression and function in human glial progenitors.''; PubMed Europe PMC Scholia
  4. Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL.; ''Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114634view16:09, 25 January 2021ReactomeTeamReactome version 75
113082view11:14, 2 November 2020ReactomeTeamReactome version 74
112316view15:23, 9 October 2020ReactomeTeamReactome version 73
101215view11:11, 1 November 2018ReactomeTeamreactome version 66
100753view20:36, 31 October 2018ReactomeTeamreactome version 65
100297view19:13, 31 October 2018ReactomeTeamreactome version 64
99843view15:57, 31 October 2018ReactomeTeamreactome version 63
99400view14:34, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
94501view09:16, 14 September 2017Mkutmonreactome version 61
88046view13:40, 25 July 2016RyanmillerOntology Term : 'transport pathway' added !
88045view13:39, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86681view09:24, 11 July 2016ReactomeTeamreactome version 56
83328view10:47, 18 November 2015ReactomeTeamVersion54
81479view13:01, 21 August 2015ReactomeTeamVersion53
76956view08:23, 17 July 2014ReactomeTeamFixed remaining interactions
76661view12:03, 16 July 2014ReactomeTeamFixed remaining interactions
75990view10:04, 11 June 2014ReactomeTeamRe-fixing comment source
75693view11:02, 10 June 2014ReactomeTeamReactome 48 Update
75049view13:56, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74693view08:45, 30 April 2014ReactomeTeamReactome46
72002view11:53, 24 October 2013EgonwSome layout work.
72000view11:50, 24 October 2013EgonwFixed the Uniprot-TrEMBL data source.
69044view17:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
42090view21:56, 4 March 2011MaintBotAutomatic update
39898view05:55, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Astrocytic EAATs REACT_14651 (Reactome)
GLUL decamer ComplexREACT_3307 (Reactome)
L-Glutamate Metabolite16015 (ChEBI)
L-Glutamine Metabolite18050 (ChEBI)
NH4+ Metabolite28938 (ChEBI)
Orthophosphate Metabolite18367 (ChEBI)
System N amino acid

transporter 1

ProteinQ9H2H9 (UniProt)

Annotated Interactions

No annotated interactions

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