Eicosanoid synthesis (Pan troglodytes)

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1Prostaglandin E26-Keto-Prostaglandin F2-alpha12-Hydroperoxy Eicosatetraenoic AcidCell Membrane15-Hydroperoxy Eicosatetraenoic AcidThromboxane A3Thromboxane B2PLA2G6LTA4HALOX5AP5-HPETE12-HETE15-HETEPeroxidase?Leukotriene A4PLA2G6PNPLA8Prostaglandin D2ALOX15BPeroxidase?Leukotriene C45-HETEALOX12Prostaglandin F2aArachidonic acidLeukotriene B4GGT1PTGES2Prostaglandin H2ALOX5PTGS2Prostaglandin I2PTGISPGE2 9-ketoreducPeroxidase?PTGDSLTC4SLeukotriene E4TBXAS1ALOX15Leukotriene D4PTGESPTGS1ALOX15PLA2G2AALOX5APDPEP1PGD2 11-ketoreducThromboxane A2ALOX5


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 64% conversion rate.

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Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117389view10:32, 21 May 2021EweitzModified title
106916view13:38, 17 September 2019MaintBotHMDB identifier normalization
89538view11:07, 16 September 2016Mkutmonontology tag fix
89480view13:39, 15 September 2016Mkutmonremove space from ontology term id
78368view10:19, 7 January 2015MaintBotadded missing graphIds
71678view19:41, 17 October 2013MaintBotAutomated update of data sources
69276view18:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67187view10:18, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62743view03:35, 2 May 2013MaintBotUpdated UniProt data source
41585view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35482view12:16, 12 February 2010Thomasadded literature
35478view12:14, 12 February 2010ThomasModified description
34314view22:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33524view09:32, 1 December 2009MaintBotRemoved group label
30423view21:16, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB01193 (HMDB)
ALOX12GeneProduct455242 (Entrez Gene)
ALOX15GeneProduct748294 (Entrez Gene)
ALOX15BGeneProduct455104 (Entrez Gene)
ALOX5GeneProduct450428 (Entrez Gene)
ALOX5APGeneProduct452520 (Entrez Gene)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
DPEP1GeneProduct
GGT1GeneProduct470168 (Entrez Gene)
LTA4HGeneProduct452145 (Entrez Gene)
LTC4SGeneProduct739986 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct456587 (Entrez Gene)
PLA2G6GeneProduct
PNPLA8GeneProduct472484 (Entrez Gene)
PTGDSGeneProduct749402 (Entrez Gene)
PTGES2GeneProduct464763 (Entrez Gene)
PTGESGeneProduct473071 (Entrez Gene)
PTGISGeneProduct458323 (Entrez Gene)
PTGS1GeneProduct464713 (Entrez Gene)
PTGS2GeneProduct469616 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
TBXAS1GeneProduct463774 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)

Annotated Interactions

No annotated interactions
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