Blood clotting cascade (Pan troglodytes)

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1Tissue InjuryFactor IXaFactor VaThrombinFibrin MonomerPlasminFactor XIIaFibrin PolymerExtrinsic PathwayFactor XIaTissue Factor+Fibrin Split ProductsIntrinsic PathwayFactor XIIIaFactor VIIa Factor Xa ThrombolysisFactor VIIIaF8A1PLAUSERPINF2F11F5F13BFGBVWFF9F10SERPINB2PLGF10F2PLATProthrombinase ComplexFGGFGAFibrinF12F8F7SERPINE1


Description

Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP272(r30179) with a 69% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Luchtman-Jones L, Broze GJ Jr; ''The current status of coagulation.''; Ann Med, 1995 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117382view10:31, 21 May 2021EweitzModified title
71684view19:41, 17 October 2013MaintBotAutomated update of data sources
69285view18:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
67096view10:05, 26 June 2013Christine ChichesterOntology Term : 'coagulation cascade pathway' added !
62746view03:35, 2 May 2013MaintBotUpdated UniProt data source
41594view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
35085view12:31, 11 February 2010Thomasfixed group positions, removed incorrect line
35083view12:28, 11 February 2010Thomasadded literature, removed braces
35072view12:03, 11 February 2010ThomasModified description
34324view22:13, 9 December 2009MaintBotAutomatic update of empty xrefs
33551view09:40, 1 December 2009MaintBotRemoved group label
30456view21:27, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
F10GeneProduct452679 (Entrez Gene)
F11GeneProduct461643 (Entrez Gene)
F12GeneProduct462304 (Entrez Gene)
F13BGeneProduct735857 (Entrez Gene)
F2GeneProduct451158 (Entrez Gene)
F5GeneProduct457500 (Entrez Gene)
F7GeneProduct744785 (Entrez Gene)
F8GeneProduct473838 (Entrez Gene)
F8A1GeneProduct
F9GeneProduct465887 (Entrez Gene)
FGAGeneProduct461559 (Entrez Gene)
FGBGeneProduct461558 (Entrez Gene)
FGGGeneProduct461560 (Entrez Gene)
FibrinMetabolite
PLATGeneProduct472748 (Entrez Gene)
PLAUGeneProduct738078 (Entrez Gene)
PLGGeneProduct463117 (Entrez Gene)
Prothrombinase ComplexGeneProduct
SERPINB2GeneProduct739078 (Entrez Gene)
SERPINE1GeneProduct472467 (Entrez Gene)
SERPINF2GeneProduct
VWFGeneProduct451773 (Entrez Gene)

Annotated Interactions

No annotated interactions
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