Endochondral ossification (Rattus norvegicus)

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1, 2CartilageProliferationChondrocyte deathHypertrophyChondrocyte (pre)hypertrophyChondrocyte proliferationFull differentiationBoneVascular invastionWNT signalingcanonical / non-canonicalRemoval of extracellular matrixand invasion by bone cellsintegrinsMineralisationOsteoblasticdifferentiationGs?DyingCathepsinsand CalpainsBMPsRemoval of cartilage matrixEnpp1TriiodothyronineBapx1TNAPVegfaGLI3Runx2Adamts4Tgfb2PrkacaMef2cCALM1Col2a1Slc38a2Timp3FrzbPtch1Serpinh1Tgfb1Spp1MgpCab39Pthr1LOC312831Ddr2PthChst11Fgf2Thyroid hormoneRunx2Growth hormoneMmp9Igf1Igf2Ctsl1Akt1PthlhBmpr1aGhrKif3aFgfr1Sox9Hdac4ThraCdkn1cThyroid hormoneSox6Runx3Mmp13Bmp6Adamts5Adamts1Tgfb1PlatCOL10A1AlplIft88Ptch1Fgfr3FGF18Stat5bPlauScinOxygenStat1cAMPRunx2Igf1rThraCst10Bmp7Hmgcs1AcanIhh


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 88% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116957view10:08, 16 May 2021EweitzModified title
107233view14:32, 17 September 2019MaintBotChEBI identifier normalization
106961view13:42, 17 September 2019MaintBotHMDB identifier normalization
87975view13:17, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72214view12:53, 27 October 2013EgonwFixed the ChEBI database name.
72174view22:17, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
69458view19:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
41790view02:43, 2 March 2011MaintBotRemoved redundant pathway information and comments
34154view19:37, 9 December 2009MaintBotAutomatic update of empty xrefs
32311view13:21, 15 August 2009MaintBotFixed text labels
31904view12:48, 14 August 2009MaintBotFixed group labels
31340view20:26, 13 August 2009MaintBotFixed text labels
31006view01:03, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProduct58968 (Entrez Gene)
Adamts1GeneProduct79252 (Entrez Gene)
Adamts4GeneProduct66015 (Entrez Gene)
Adamts5GeneProduct304135 (Entrez Gene)
Akt1GeneProduct24185 (Entrez Gene)
AlplGeneProduct25586 (Entrez Gene)
Bapx1GeneProduct
Bmp6GeneProduct25644 (Entrez Gene)
Bmp7GeneProduct85272 (Entrez Gene)
Bmpr1aGeneProduct81507 (Entrez Gene)
CALM1GeneProduct24242 (Entrez Gene)
COL10A1GeneProduct25681 (Entrez Gene)
Cab39GeneProduct301574 (Entrez Gene)
Cdkn1cGeneProduct246060 (Entrez Gene)
Chst11GeneProduct314694 (Entrez Gene)
Col2a1GeneProduct25412 (Entrez Gene)
Cst10GeneProduct366219 (Entrez Gene)
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
Ctsl1GeneProduct25697 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
Ddr2GeneProduct685781 (Entrez Gene)
Enpp1GeneProduct85496 (Entrez Gene)
FGF18GeneProduct29369 (Entrez Gene)
Fgf2GeneProduct54250 (Entrez Gene)
Fgfr1GeneProduct79114 (Entrez Gene)
Fgfr3GeneProduct84489 (Entrez Gene)
FrzbGeneProduct295691 (Entrez Gene)
GLI3GeneProduct140588 (Entrez Gene)
GhrGeneProduct25235 (Entrez Gene)
Growth hormoneGeneProduct
Hdac4GeneProduct363287 (Entrez Gene)
Hmgcs1GeneProduct29637 (Entrez Gene)
Ift88GeneProduct305918 (Entrez Gene)
Igf1GeneProduct24482 (Entrez Gene)
Igf1rGeneProduct25718 (Entrez Gene)
Igf2GeneProduct24483 (Entrez Gene)
IhhGeneProduct84399 (Entrez Gene)
Kif3aGeneProduct84392 (Entrez Gene)
LOC312831GeneProduct312831 (Entrez Gene)
Mef2cGeneProduct499497 (Entrez Gene)
MgpGeneProduct25333 (Entrez Gene)
Mmp13GeneProduct171052 (Entrez Gene)
Mmp9GeneProduct81687 (Entrez Gene)
OxygenMetaboliteHMDB01377 (HMDB)
PlatGeneProduct25692 (Entrez Gene)
PlauGeneProduct25619 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
Ptch1GeneProduct89830 (Entrez Gene)
PthGeneProduct24694 (Entrez Gene)
PthlhGeneProduct24695 (Entrez Gene)
Pthr1GeneProduct56813 (Entrez Gene)
Runx2GeneProduct367218 (Entrez Gene)
Runx3GeneProduct156726 (Entrez Gene)
ScinGeneProduct298975 (Entrez Gene) PMID: 17097081
Serpinh1GeneProduct29345 (Entrez Gene)
Slc38a2GeneProduct29642 (Entrez Gene)
Sox6GeneProduct293165 (Entrez Gene)
Sox9GeneProduct140586 (Entrez Gene)
Spp1GeneProduct25353 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
TNAPGeneProduct
Tgfb1GeneProduct59086 (Entrez Gene)
Tgfb2GeneProduct81809 (Entrez Gene)
ThraGeneProduct81812 (Entrez Gene)
Thyroid hormoneMetaboliteT4
Timp3GeneProduct25358 (Entrez Gene)
TriiodothyronineMetaboliteT3
VegfaGeneProduct83785 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions
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