IL-2 signaling pathway (Danio rerio)

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NUControlPhosphorylationAcetylationEndoplasmic reticulumDProteins in a complex interactionActivationPlasma membraneCY -> NUPalmitolyationExtracellularAutophosphorylation(Protein-protein interaction)CY -> NUDeacetylationDPMCY -> NUMethylationNUDesumoylationInhibitionDReactions through unknown mechanisms/moleculesNucleusEndosomeSumoylationCY -> NUGolgi apparatusMolecular associationRecruitmentMolecule in the pathwayProteolytic cleavageLigandPM -> CYTranslocationNucleusReceptorDMTAccession Number: NetPath 14CytoplasmEnzyme complexDCY -> NUENDemethylationCY -> NUDDMitochondrionDDDephosphorylationDeubiquitinationECMTUbiquitinationGlycosylationGene SymbolDDCY -> PMCYERGOCY -> NUDCY -> NUPhosphorylationzgc:172250mapk3NFKB1raf1raf1zgc:92106LOC564517LOC792354tertLOC561737VAV1nr3c1relaSTAT5Bjak1cblitm2bastammapk1eif3bcrkljak2bhsp90a.2grb2zgc:172209sykPLCB1LOC792354map2k1zgc:101581fynbmapk3LOC557176ybx1stat3IL2SOCS3socs1frap1cishIL2ets1aSTAT5Bwu:fb92a07SHBLCKIL2ptpn11NFKB1IL2RBLOC792354IFNA1zgc:92124zgc:64051pik3r2BCL2ptk2bbcreb1stat1afoxo5zgc:77033LOC563639STAT5Aybx1SOS1chukLOC100149273IL2RAcrktertmapkapk2aIL2LOC559281ptpn6mapk1IL2RGIL2stam2STAT5ANMIrps6kb1gnb2l1IRS2mapk14arelamknk1JAK3pik3cdICAM1prkczcrkkras


Description

Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_14

Comments

GenMAPP notes 
NetPath 14 - IL-2 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 71% conversion rate.

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116878view11:00, 15 May 2021EweitzModified title
115957view08:23, 22 March 2021EgonwCopied the NetPath paper into the literature list
115947view07:12, 22 March 2021EgonwModified description
89852view12:18, 6 October 2016Mkutmonremove GenMAPP notes
89848view12:16, 6 October 2016MkutmonModified description
70236view21:24, 15 July 2013MaintBotupdated to 2013 schema
67367view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
40829view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35786view06:21, 13 February 2010MaintBotAdded description
34215view21:33, 9 December 2009MaintBotAutomatic update of empty xrefs
31348view20:29, 13 August 2009MaintBotFixed text labels
31029view01:13, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BCL2GeneProduct570772 (Entrez Gene)
ICAM1GeneProduct
IFNA1GeneProduct
IL2GeneProduct
IL2RAGeneProduct
IL2RBGeneProduct793920 (Entrez Gene)
IL2RGGeneProduct
IRS2GeneProduct
JAK3GeneProduct561370 (Entrez Gene)
LCKGeneProduct414333 (Entrez Gene)
LOC100149273GeneProduct100149273 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC559281GeneProduct559281 (Entrez Gene)
LOC561737GeneProduct561737 (Entrez Gene)
LOC563639GeneProduct563639 (Entrez Gene)
LOC564517GeneProduct564517 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
NFKB1GeneProduct565756 (Entrez Gene)
NMIGeneProduct335331 (Entrez Gene)
PLCB1GeneProduct
SHBGeneProduct
SOCS3GeneProduct
SOS1GeneProduct
STAT5AGeneProduct
STAT5BGeneProduct
VAV1GeneProduct
cblGeneProduct492364 (Entrez Gene)
chukGeneProduct393287 (Entrez Gene)
cishGeneProduct767678 (Entrez Gene)
creb1GeneProduct573207 (Entrez Gene)
crkGeneProduct445234 (Entrez Gene)
crklGeneProduct556443 (Entrez Gene)
eif3bGeneProduct796380 (Entrez Gene)
ets1aGeneProduct280651 (Entrez Gene)
foxo5GeneProduct30296 (Entrez Gene)
frap1GeneProduct324254 (Entrez Gene)
fynbGeneProduct574422 (Entrez Gene)
gnb2l1GeneProduct30722 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
hsp90a.2GeneProduct565155 (Entrez Gene)
itm2baGeneProduct323632 (Entrez Gene)
jak1GeneProduct30280 (Entrez Gene)
jak2bGeneProduct30298 (Entrez Gene)
krasGeneProduct445289 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk14aGeneProduct65237 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
mapkapk2aGeneProduct327321 (Entrez Gene)
mknk1GeneProduct555974 (Entrez Gene)
nr3c1GeneProduct553740 (Entrez Gene)
pik3cdGeneProduct394174 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
prkczGeneProduct555737 (Entrez Gene)
ptk2bbGeneProduct245950 (Entrez Gene)
ptpn11GeneProduct333979 (Entrez Gene)
ptpn6GeneProduct335573 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
relaGeneProduct415099 (Entrez Gene)
rps6kb1GeneProduct406349 (Entrez Gene)
socs1GeneProduct445073 (Entrez Gene)
stam2GeneProduct492497 (Entrez Gene)
stamGeneProduct386967 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
sykGeneProduct405769 (Entrez Gene)
tertGeneProduct796551 (Entrez Gene)
wu:fb92a07GeneProduct100002263 (Entrez Gene)
ybx1GeneProduct58144 (Entrez Gene)
zgc:101581GeneProduct493617 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)
zgc:64051GeneProduct393342 (Entrez Gene)
zgc:77033GeneProduct406598 (Entrez Gene)
zgc:92106GeneProduct326672 (Entrez Gene)
zgc:92124GeneProduct447804 (Entrez Gene)

Annotated Interactions

No annotated interactions
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