Retinoblastoma gene in cancer (Homo sapiens)

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321MSH6SUV39H1TLX2CCNE1CBX5RPA1TFDP1RRM1CKS1BCDKN1BABL1CCNA2ANLNCDT1RBP1DHFRE2F1CCNE1CDC7TFDP2TOP2AGTPBP1CCNE2DYRK2HLTFCCND3POLEPOLA1MDM2ABL1RRM2DBF4PRMT2EFNB2NCAPHRAF1CDC45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestregulation of cyclin-dependent protein kinase activityTP53HMGB1SKP2CCNB2PRKDCJUNMCM7BARD1CDK2SMARCA2CDC25ASMC2RB1histone H3-K9 methylationDNA replicationPRC1ORC1CDKN1BMYCRBBP4KIF4AMASP1CCNA1TTKCCNA2ATMHMGB2DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisCHEK1CDK1SP1G1/S transition of mitotic cell cycleG1/S transition of mitotic cell cycleRFC3CCDC6RFC5STMN1HDAC1RAF1RPA1CDKN1ACCNE1LY6EBRCA1CCND1RABIFJNK cascadeMCM3PCNACDK1DNMT1CDK1CCNB1TFAMRPA2PLK1RFC4RPA3CDKN1CMCM4DCKCDK1TYMSPLK4MAPK13CCNA2E2F1MDM2RPA3MCM6RBL1NPATPRIM1PathwayDNA damage response, signal transduction resulting in induction of apoptosisKIF22MCM7PLK4RB1RB1TFDP1E2F1RB1SKP2RB1TFDP1E2F1TFDP1E2F2TFDP1E2F3RB1RB1ZNF655RB1RB1MDM2TFDP1E2F1MDM2RBP1HDAC1TFDP1E2F1RB1RB1TFDP1E2F1RB1RB1RB1RB1SP1RB1RB1JUNTP53E2F1E2F3E2F2SKP2E2F3TFDP1G1/S transition of mitotic cell cycleG1/S transition of mitotic cell cycle


Description

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Bibliography

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  1. Welch PJ, Wang JY; ''A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.''; Cell, 1993 PubMed Europe PMC Scholia
  2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC Scholia
  4. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L; ''An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  5. Welch PJ, Wang JY; ''Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.''; Mol Cell Biol, 1995 PubMed Europe PMC Scholia
  6. Domínguez R, Famulari A, Vila J; ''[Leukoencephalopathy: the frontier between what is reversible and what is persistent].''; Rev Neurol, 1997 PubMed Europe PMC Scholia
  7. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116593view16:31, 8 May 2021EweitzModified title
113796view11:10, 24 November 2020Finterlysmall graphical update
108145view10:34, 29 November 2019FehrhartOntology Term : 'cancer' added !
108144view10:34, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106493view21:43, 4 September 2019KhanspersModified description
105447view04:57, 8 August 2019KhanspersModified description
102997view14:43, 31 January 2019Mkutmonupdated outdated ensembl ids
98748view01:20, 4 October 2018AlexanderPicoModified title
98747view01:20, 4 October 2018AlexanderPicoModified title
98354view05:35, 24 August 2018EgonwUpdated the MIR21 identifier.
87639view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84651view22:24, 10 March 2016KhanspersQuick edit to datanode annotation or property
80443view05:49, 23 June 2015KhanspersAdded mir29b targeting of CDK6
80434view20:26, 22 June 2015KhanspersAdded mir21 targeting of MSH6
80433view20:17, 22 June 2015KhanspersAdded mir21 targetinf of E2F1
80430view20:00, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80174view11:06, 16 May 2015EveloModified title
80173view11:01, 16 May 2015EveloModified description
80172view10:44, 16 May 2015EveloModified description
80171view10:40, 16 May 2015EveloModified description
78573view14:50, 7 January 2015MaintBotadded missing graphIds
76353view18:32, 3 July 2014EgonwRemoved database names when no identifier was given.
76335view22:48, 2 July 2014MaintBotchanged pathway node Xrefs
72248view22:23, 29 October 2013MaintBotchanged xrefs from Gene Ontology to WikiPathways
71096view14:30, 4 October 2013Mkutmonconnected lines
70977view04:49, 19 September 2013JYoungrenSpecify description
70976view04:40, 19 September 2013JYoungrenPeriodical save, work in progress
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70934view23:18, 15 September 2013JYoungrenSpecify description
70933view22:39, 15 September 2013JYoungrenPeriodical save, work in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ANLNGeneProduct54443 (Entrez Gene)
ATMGeneProduct472 (Entrez Gene)
BARD1GeneProduct580 (Entrez Gene)
BRCA1GeneProduct672 (Entrez Gene)
CBX5GeneProduct23468 (Entrez Gene)
CCDC6GeneProduct8030 (Entrez Gene)
CCNA1GeneProduct8900 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCNB2GeneProduct9133 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC45GeneProduct8318 (Entrez Gene)
CDC7GeneProduct8317 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDKN1CGeneProduct1028 (Entrez Gene)
CDT1GeneProduct81620 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene)
CKS1BGeneProduct1163 (Entrez Gene)
DBF4GeneProduct10926 (Entrez Gene)
DCKGeneProduct1633 (Entrez Gene)
DHFRGeneProduct1719 (Entrez Gene)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestPathwayGO:0006977 (GeneOntology)
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisPathwayGO:0042771 (GeneOntology)
DNA damage response, signal transduction resulting in induction of apoptosisPathwayGO:0008630 (GeneOntology)
DNA replicationPathwayGO:0006260 (GeneOntology)
DNMT1GeneProduct1786 (Entrez Gene)
DYRK2GeneProduct8445 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
EFNB2GeneProduct1948 (Entrez Gene)
G1/S transition of mitotic cell cyclePathwayGO:0000082 (GeneOntology)
GTPBP1GeneProduct9567 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HLTFGeneProduct6596 (Entrez Gene)
HMGB1GeneProduct3146 (Entrez Gene)
HMGB2GeneProduct3148 (Entrez Gene)
JNK cascadePathwayGO:0007254 (GeneOntology)
JUNGeneProduct3725 (Entrez Gene)
KIF22GeneProduct3835 (Entrez Gene)
KIF4AGeneProduct24137 (Entrez Gene)
LY6EGeneProduct4061 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MASP1GeneProduct5648 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MSH6GeneProduct2956 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NCAPHGeneProduct23397 (Entrez Gene)
NPATGeneProduct4863 (Entrez Gene)
ORC1GeneProduct4998 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PLK1GeneProduct5347 (Entrez Gene)
PLK4GeneProduct10733 (Entrez Gene)
POLA1GeneProduct5422 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRC1GeneProduct9055 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRKDCGeneProduct5591 (Entrez Gene)
PRMT2GeneProduct3275 (Entrez Gene)
PathwayPathway
RABIFGeneProduct5877 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBBP4GeneProduct5928 (Entrez Gene)
RBL1GeneProduct5933 (Entrez Gene)
RBP1GeneProduct5947 (Entrez Gene)
RFC3GeneProduct5983 (Entrez Gene)
RFC4GeneProduct5984 (Entrez Gene)
RFC5GeneProduct5985 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2Protein6118 (Entrez Gene)
RPA3Protein6119 (Entrez Gene)
RRM1GeneProduct6240 (Entrez Gene)
RRM2GeneProduct6241 (Entrez Gene)
SKP2GeneProduct6502 (Entrez Gene)
SMARCA2GeneProduct6595 (Entrez Gene)
SMC2GeneProduct10592 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
SUV39H1GeneProduct6839 (Entrez Gene)
TFAMGeneProduct7019 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TLX2GeneProduct3196 (Entrez Gene)
TOP2AGeneProduct7153 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TTKGeneProduct7272 (Entrez Gene)
TYMSGeneProduct7298 (Entrez Gene)
ZNF655Protein79027 (Entrez Gene)
histone H3-K9 methylationPathwayGO:0051567 (GeneOntology)
regulation of cyclin-dependent protein kinase activityPathwayGO:0000079 (GeneOntology)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2446"
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