Primary focal segmental glomerulosclerosis (FSGS) (Homo sapiens)

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1-8PACTIN+ACTINSLIT DIAPHRAGMDISRUPTIONF-ACTINLegendCALCINEURINCALCIUMP13KMICRORNA 193AAPOPTOSISTT: Therapeutic Target (decrease)PKATT: Therapeutic Target (increase)3P21PODOCYTOPENIAPodocyte-Associated Genetic Glomerular DiseasesPROTEIN17Q25GENEARSTABILIZES PODOCYTECYTOSKELETONMATERNAL10Q23PRIMARY INJURYESRDARARNUCLEUS11P15.5NonsyndromicSyndromicPRIMARY FSGSAR15Q21-Q229Q33.3TYPE4Q21.1IRF6TLR4LAMA5FAKITGB3VCLCD151KIRREL2SYNPOKIRREL3AGRNDKK1DNM1AKT1TGFB1FYNCAMK2BITGAVVTN14-3-3JAG1CTSLNCK1PTPROPLAURCD2APCsAKRT8NPHS2LAMB2NPHS1PLCG1CDKN1BRITUXIMABCR1PAX2PODXLLMX1BMYO1ESCARB2MT-TL1NON-MUSCLE MYOSIN-1EFAT1LMX1BITGB4MT-TL1COL4A5CDKN1CMMEMYCOPHENOLATE MOFETILVIMCDKN1ACD151PODXLNPHS1PLCE1CD2APACTN4NMMHCHHARPWT1FORMIN INF2TRPC6AACTININ4CD2APPHOSPHOLIPASE CE1PODOCINNEPHRINMYH9SMARCAL1WT1INF2TRPC61Q25-Q3119Q136P12.311P132Q3519Q13.122Q12.311Q21-2214QCHROMOSOMETRANSMISSIONARARADAD/ARADADADARCOMPLEXLAMB2ITGB4CD151ARSCARB2ARADWT1PCNAMKI67CADHERINCLDN1DESTRUCTION OFPODOCYTEARCHITECTURENUCLEUSPODOCYTETTWT1SYNPOCOL4A3COL4A4ACTN4GLOMERULAR BASEMENT MEMBRANENORMAL PODOCYTELIMS1NPHS1PODOCINCD80NOTCH1+P-SYNPOGLOMERULAR BASEMENT MEMBRANETTTTTTTTTTTTTTTTTTTTTTTTTTCTNNB1NOTCH1LRP6LRP5TTTTTTTRPC6TTTTTTTTTTTTTTTTTTTTTTGLOMERULAR BASEMENT MEMBRANENORMALEPITOPESPAXTTANTICLA4TTTLN1ILKITGB1ITGA3Proteins involved in Podocyte cytoskeletonDAG1PARVAILKUTRNWNT1Y-SECRETASE


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Meyrier A; ''Focal and segmental glomerulosclerosis: multiple pathways are involved.''; Semin Nephrol, 2011 PubMed Europe PMC Scholia
  2. Reiser J, Gupta V, Kistler AD; ''Toward the development of podocyte-specific drugs.''; Kidney Int, 2010 PubMed Europe PMC Scholia
  3. Gebeshuber CA, Kornauth C, Dong L, Sierig R, Seibler J, Reiss M, Tauber S, Bilban M, Wang S, Kain R, Bط·آ£ط¢آ¶hmig GA, Moeller MJ, Grط·آ£ط¢آ¶ne HJ, Englert C, Martinez J, Kerjaschki D; ''Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.''; Nat Med, 2013 PubMed Europe PMC Scholia
  4. Canaud G, Martinez F, Noط·آ£ط¢آ«l LH, Mamzer MF, Niaudet P, Legendre C; ''Therapeutic approach to focal and segmental glomerulosclerosis recurrence in kidney transplant recipients.''; Transplant Rev (Orlando), 2010 PubMed Europe PMC Scholia
  5. Howie AJ; ''Problems with 'focal segmental glomerulosclerosis'.''; Pediatr Nephrol, 2011 PubMed Europe PMC Scholia
  6. Kato H, Susztak K; ''Repair problems in podocytes: Wnt, Notch, and glomerulosclerosis.''; Semin Nephrol, 2012 PubMed Europe PMC Scholia
  7. Hu, G, Jiao,B; ''Mechanism of podocyte detachment: Targeting transmembrane molecules between podocytes and glomerular basement membrane''; Biomedicine & Aging Pathology, 2013 DOI Scholia
  8. Rood IM, Deegens JK, Wetzels JF; ''Genetic causes of focal segmental glomerulosclerosis: implications for clinical practice.''; Nephrol Dial Transplant, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
119251view19:32, 22 June 2021FinterlyAdded DOI to PublicationXref
116556view12:53, 7 May 2021EweitzModified title
106533view23:58, 5 September 2019Khanspersfixed interactions
106532view23:51, 5 September 2019KhanspersModified description
105791view19:48, 15 August 2019KhanspersModified description
97626view08:58, 31 May 2018AMTanOntology Term : 'focal segmental glomerulosclerosis' added !
90019view19:28, 8 October 2016AlexanderPicoModified description
89876view12:52, 6 October 2016MkutmonModified description
79947view10:16, 28 April 2015ZariChanged HNGC ID to Ensembl ID TGFB1
79296view13:19, 20 March 2015Zari
79295view12:20, 20 March 2015Zarichanged Identifier for VNT
78521view10:29, 7 January 2015MaintBotadded missing graphIds
76327view08:08, 2 July 2014MkutmonFixed identifier for FAK
76326view08:07, 2 July 2014MkutmonChanged database annotations from "Ensembl Human" to "Ensembl"
76325view08:03, 2 July 2014Mkutmonreplaced annotation for geneproducts from OMIM to Ensembl
76324view08:02, 2 July 2014Mkutmonreplaced annotation for geneproducts from OMIM to Ensembl
72200view11:10, 27 October 2013EgonwFixed the PubChem-compound database name.
71217view20:30, 14 October 2013DMicaelSpecify description
71211view18:08, 14 October 2013DMicaelSpecify description
71210view18:06, 14 October 2013DMicaelSpecify description
71209view18:04, 14 October 2013DMicaelSpecify description
71208view18:01, 14 October 2013DMicaelSpecify description
71207view17:56, 14 October 2013DMicaelSpecify description
71152view21:17, 10 October 2013MaintBotfixed publication xrefs
71099view17:04, 4 October 2013DMicaelModified title
71098view17:02, 4 October 2013DMicaelModified description
71097view16:34, 4 October 2013DMicaelModified description
71080view02:24, 3 October 2013DMicaelModified title
71072view03:18, 2 October 2013DMicaelOntology Term : 'glomerular capillary endothelial cell' added !
71071view03:14, 2 October 2013DMicaelOntology Term : 'renal failure pathway' added !
71065view21:15, 1 October 2013DMicaelModified title
71064view21:03, 1 October 2013DMicaelModified description
71063view20:57, 1 October 2013DMicaelModified description
71062view20:52, 1 October 2013DMicaelNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
14-3-3GeneProductENSG00000134308 (Ensembl Human)
AACTININ4GeneProductMIM:604638 (OMIM)
ACTN4GeneProductMIM:604638 (OMIM)
AGRNGeneProductENSG00000188157 (Ensembl Human)
AKT1GeneProductENSG00000142208 (Ensembl Human)
CADHERINGeneProductENSG00000170558 (Ensembl Human)
CAMK2BGeneProductENSG00000058404 (Ensembl Human)
CD151GeneProductENSG00000177697 (Ensembl Human)
CD2APGeneProductENSG00000198087 (Ensembl Human)
CD80GeneProductENSG00000121594 (Ensembl Human)
CDKN1AGeneProductENSG00000124762 (Ensembl Human)
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CDKN1CGeneProductENSG00000129757 (Ensembl Human)
CLDN1GeneProductENSG00000163347 (Ensembl Human)
COL4A3GeneProductENSG00000169031 (Ensembl Human)
COL4A4GeneProductENSG00000081052 (Ensembl Human)
COL4A5GeneProductENSG00000188153 (Ensembl Human)
CR1GeneProductENSG00000203710 (Ensembl Human)
CTNNB1GeneProductENSG00000168036 (Ensembl Human)
CTSLGeneProductENSG00000135047 (Ensembl Human)
CsAMetaboliteCID 5284373 (PubChem)
DAG1GeneProductENSG00000173402 (Ensembl Human)
DKK1GeneProductENSG00000107984 (Ensembl Human)
DNM1GeneProductENSG00000106976 (Ensembl Human)
FAKGeneProductEnsembl:ENSG00000169398 (Ensembl Human)
FAT1GeneProductENSG00000083857 (Ensembl Human)
FORMIN INF2 GeneProductENSG00000203485 (Ensembl Human)
FYNGeneProductENSG00000010810 (Ensembl Human)
HHARPGeneProductENSG00000138375 (Ensembl Human)
ILKGeneProductENSG00000166333 (Ensembl Human)
INF2GeneProductENSG00000203485 (Ensembl Human)
IRF6GeneProductENSG00000117595 (Ensembl Human)
ITGA3GeneProductENSG00000005884 (Ensembl Human)
ITGAVGeneProductENSG00000138448 (Ensembl Human)
ITGB1GeneProductENSG00000150093 (Ensembl Human)
ITGB3GeneProductENSG00000259207 (Ensembl Human)
ITGB4GeneProductENSG00000132470 (Ensembl Human)
JAG1GeneProductENSG00000101384 (Ensembl Human)
KIRREL2GeneProductENSG00000126259 (Ensembl Human)
KIRREL3GeneProductENSG00000149571 (Ensembl Human)
KRT8GeneProductENSG00000170421 (Ensembl Human)
LAMA5GeneProductENSG00000130702 (Ensembl Human)
LAMB2GeneProductENSG00000172037 (Ensembl Human)
LIMS1GeneProductENSG00000169756 (Ensembl Human)
LMX1BGeneProductENSG00000136944 (Ensembl Human)
LRP5GeneProductENSG00000162337 (Ensembl Human)
LRP6GeneProductENSG00000070018 (Ensembl Human)
MKI67GeneProductENSG00000148773 (Ensembl Human)
MMEGeneProductENSG00000196549 (Ensembl Human)
MT-TL1GeneProductMIM:590050 (OMIM)
MYCOPHENOLATE MOFETILMetabolite5281078 (PubChem)
MYH9GeneProductENSG00000100345 (Ensembl Human)
MYO1EGeneProductENSG00000157483 (Ensembl Human)
NCK1GeneProductENSG00000158092 (Ensembl Human)
NEPHRIN GeneProductENSG00000161270 (Ensembl Human)
NMMHCGeneProductENSG00000100345 (Ensembl Human)
NON-MUSCLE MYOSIN-1EGeneProductENSG00000157483 (Ensembl Human)
NOTCH1GeneProductENSG00000148400 (Ensembl Human)
NPHS1GeneProductENSG00000161270 (Ensembl Human)
NPHS2GeneProductENSG00000116218 (Ensembl Human)
PARVAGeneProductMIM:608120 (OMIM)
PAX2GeneProductENSG00000075891 (Ensembl Human)
PCNAGeneProductENSG00000132646 (Ensembl Human)
PHOSPHOLIPASE CE1GeneProductENSG00000138193 (Ensembl Human)
PLAURGeneProductENSG00000011422 (Ensembl Human)
PLCE1GeneProductENSG00000138193 (Ensembl Human)
PLCG1GeneProductENSG00000124181 (Ensembl Human)
PODOCINGeneProductENSG00000116218 (Ensembl Human)
PODXLGeneProductENSG00000128567 (Ensembl Human)
PTPROGeneProductENSG00000151490 (Ensembl Human)
RITUXIMABMetabolite174722-31-7 (CAS)
SCARB2GeneProductENSG00000138760 (Ensembl Human)
SMARCAL1GeneProductENSG00000138375 (Ensembl Human)
SYNPOGeneProductENSG00000171992 (Ensembl Human)
TGFB1GeneProduct11766 (HGNC)
TLN1GeneProductENSG00000137076 (Ensembl Human)
TLR4GeneProductENSG00000136869 (Ensembl Human)
TRPC6GeneProductENSG00000137672 (Ensembl Human)
UTRNGeneProductENSG00000152818 (Ensembl Human)
VCLGeneProductENSG00000035403 (Ensembl Human)
VIMGeneProductENSG00000026025 (Ensembl Human)
VTNGeneProduct12724 (HGNC)
WNT1GeneProduct164820 (OMIM)
WT1GeneProductENSG00000184937 (Ensembl Human)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2572"
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